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CDK11A cyclin dependent kinase 11A [ Homo sapiens (human) ]

Gene ID: 728642, updated on 13-Feb-2019

Summary

Official Symbol
CDK11Aprovided by HGNC
Official Full Name
cyclin dependent kinase 11Aprovided by HGNC
Primary source
HGNC:HGNC:1730
See related
Ensembl:ENSG00000008128 MIM:116951
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC2L2; CDC2L3; p58GTA; PITSLRE; CDK11-p46; CDK11-p58; CDK11-p110
Summary
This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 22.4), small intestine (RPKM 18.4) and 25 other tissues See more
Orthologs

Genomic context

See CDK11A in Genome Data Viewer
Location:
1p36.33
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (1702383..1724565, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1633822..1655999, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member E2B Neighboring gene ribosomal protein S7 pseudogene Neighboring gene matrix metallopeptidase 23A (pseudogene) Neighboring gene solute carrier family 35 member E2A Neighboring gene ribosomal protein S7 pseudogene Neighboring gene uncharacterized LOC112268218 Neighboring gene NAD kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ55257, FLJ56415, FLJ56557, MGC131975

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of cell growth IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of mRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 11A
Names
PITSLRE B
PITSLRE protein kinase beta SV1 isoform
PITSLRE protein kinase beta SV16 isoform
PITSLRE protein kinase beta SV17 isoform
PITSLRE protein kinase beta SV18 isoform
PITSLRE protein kinase beta SV2 isoform
PITSLRE protein kinase beta SV3 isoform
PITSLRE protein kinase beta SV6 isoform
PITSLRE serine/threonine-protein kinase CDC2L2
cell division cycle 2-like 2 (PITSLRE proteins)
cell division cycle 2-like protein kinase 2
cell division protein kinase 11A
galactosyltransferase-associated protein kinase p58/GTA
NP_001300825.1
NP_001300911.1
NP_076916.2
NP_277071.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029414.1 RefSeqGene

    Range
    4788..26970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001313896.1NP_001300825.1  cyclin-dependent kinase 11A isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in the central coding region compared to variant 1. The encoded isoform (5) is longer than isoform 1.
    Source sequence(s)
    AF067522, AL031282, BC073855
    Consensus CDS
    CCDS81253.1
    UniProtKB/Swiss-Prot
    Q9UQ88
    Related
    ENSP00000367900.1, ENST00000378633.5
    Conserved Domains (2) summary
    cd07843
    Location:420711
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:423713
    PLN00009; cyclin-dependent kinase A; Provisional
  2. NM_001313982.1NP_001300911.1  cyclin-dependent kinase 11A isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AF067520, AL031282, BC073855
    Consensus CDS
    CCDS81254.1
    UniProtKB/Swiss-Prot
    Q9UQ88
    UniProtKB/TrEMBL
    Q5QPR3
    Related
    ENSP00000350403.2, ENST00000357760.6
    Conserved Domains (2) summary
    cd07843
    Location:416707
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:419709
    PLN00009; cyclin-dependent kinase A; Provisional
  3. NM_024011.4NP_076916.2  cyclin-dependent kinase 11A isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AF067519, AL031282, AL043340, BC073855, BC094827, DC388505
    Consensus CDS
    CCDS44042.1
    UniProtKB/Swiss-Prot
    Q9UQ88
    UniProtKB/TrEMBL
    Q4VBY6
    Related
    ENSP00000384442.3, ENST00000404249.7
    Conserved Domains (2) summary
    cd07843
    Location:417708
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:420710
    PLN00009; cyclin-dependent kinase A; Provisional
  4. NM_033529.3NP_277071.2  cyclin-dependent kinase 11A isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF067521, AL031282, AL043340, BC073855, BC094827, DC388505
    Consensus CDS
    CCDS44043.1
    UniProtKB/Swiss-Prot
    Q9UQ88
    UniProtKB/TrEMBL
    Q4VBY6
    Related
    ENSP00000351629.5, ENST00000358779.9
    Conserved Domains (2) summary
    cd07843
    Location:407698
    STKc_CDC2L1; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1
    PLN00009
    Location:410700
    PLN00009; cyclin-dependent kinase A; Provisional

RNA

  1. NR_132739.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF067518, AL031282, BC073855
  2. NR_132740.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses two alternate internal splice sites compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF067523, AL031282, BC073855

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    1702383..1724565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_033527.1: Suppressed sequence

    Description
    NM_033527.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_033532.1: Suppressed sequence

    Description
    NM_033532.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  3. NM_033534.1: Suppressed sequence

    Description
    NM_033534.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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