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TPR translocated promoter region, nuclear basket protein [ Homo sapiens (human) ]

Gene ID: 7175, updated on 5-Apr-2020

Summary

Official Symbol
TPRprovided by HGNC
Official Full Name
translocated promoter region, nuclear basket proteinprovided by HGNC
Primary source
HGNC:HGNC:12017
See related
Ensembl:ENSG00000047410 MIM:189940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 29.9), thyroid (RPKM 16.2) and 25 other tissues See more
Orthologs

Genomic context

See TPR in Genome Data Viewer
Location:
1q31.1
Exon count:
51
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (186311652..186375253, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (186280784..186344883, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene hemicentin 1 Neighboring gene Sharpr-MPRA regulatory region 5860 Neighboring gene uncharacterized LOC105371654 Neighboring gene RNA, U6 small nuclear 1240, pseudogene Neighboring gene proteoglycan 4 Neighboring gene odr-4 GPCR localization factor homolog Neighboring gene PDC antisense RNA 1 Neighboring gene phosducin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 replication requires PSIP1 (LEDGF/p75) and TPR to maintain chromatin structure amenable to integration as shown through shRNA treatment PubMed
HIV-1 requires NUP153 and TPR for infectivity as shown by shRNA knockdown experiments utilizing HeLa-derived P4-CCR5 cells and jurkat T cells PubMed
Knockdown of translocated promoter region (to activated MET oncogene) (TPR) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated nucleoprotein TPR is incorporated into HIV-1 Gag virus-like particles PubMed
Tat tat Depletion of translocated promoter region, nuclear basket protein (TPR) by siRNA enhances HIV-1 Tat activation of HIV-1 LTR, which is not the results of increased Tat expression and release of CDK9/CCNT1 from 7SK snRNP, and activation of NF-kappaB PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
dynein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
heat shock protein binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mitogen-activated protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein membrane anchor IMP
Inferred from Mutant Phenotype
more info
PubMed 
structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to interferon-alpha ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular transport of virus TAS
Traceable Author Statement
more info
 
mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
mRNA export from nucleus in response to heat stress IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of RNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of RNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT nuclear matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT nuclear pore complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear pore organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT nuclear pore organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of heterochromatin assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein sumoylation TAS
Traceable Author Statement
more info
 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of glycolytic process TAS
Traceable Author Statement
more info
 
NOT regulation of mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic sister chromatid separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to epidermal growth factor IDA
Inferred from Direct Assay
more info
PubMed 
tRNA export from nucleus TAS
Traceable Author Statement
more info
 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
host cell IEA
Inferred from Electronic Annotation
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
NOT kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore nuclear basket IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleoprotein TPR
Names
NPC-associated intranuclear protein
megator
nuclear pore complex-associated protein TPR
translocated promoter region (to activated MET oncogene)
translocated promoter region protein
tumor potentiating region

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023284.1 RefSeqGene

    Range
    5073..68674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003292.3NP_003283.2  nucleoprotein TPR

    See identical proteins and their annotated locations for NP_003283.2

    Status: REVIEWED

    Source sequence(s)
    AA688415, AL133553, AL596220, U69668, X66397
    Consensus CDS
    CCDS41446.1
    UniProtKB/Swiss-Prot
    P12270
    Related
    ENSP00000356448.3, ENST00000367478.9
    Conserved Domains (5) summary
    COG1196
    Location:53796
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR04527
    Location:9641050
    mycoplas_twoTM; two transmembrane protein
    pfam00038
    Location:7651087
    Filament; Intermediate filament protein
    pfam07851
    Location:14331509
    TMPIT; TMPIT-like protein
    pfam07926
    Location:10381166
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    186311652..186375253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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