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Tpr translocated promoter region, nuclear basket protein [ Mus musculus (house mouse) ]

Gene ID: 108989, updated on 5-Mar-2024

Summary

Official Symbol
Tprprovided by MGI
Official Full Name
translocated promoter region, nuclear basket proteinprovided by MGI
Primary source
MGI:MGI:1922066
See related
Ensembl:ENSMUSG00000006005 AllianceGenome:MGI:1922066
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610029M07Rik
Summary
Predicted to enable several functions, including dynein complex binding activity; mitogen-activated protein kinase binding activity; and protein homodimerization activity. Predicted to be a structural constituent of nuclear pore. Involved in cellular response to interferon-alpha. Located in nuclear envelope; nuclear inclusion body; and nuclear periphery. Part of nuclear pore. Is expressed in several structures, including alimentary system; brain ventricular layer; genitourinary system; olfactory epithelium; and vibrissa. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 19.4), placenta adult (RPKM 13.2) and 28 other tissues See more
Orthologs
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Genomic context

Location:
1 G1; 1 63.84 cM
Exon count:
52
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (150268544..150325686)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (150392802..150449935)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein BEX4-like Neighboring gene STARR-seq mESC enhancer starr_02598 Neighboring gene RIKEN cDNA 2310030A07 gene Neighboring gene STARR-seq mESC enhancer starr_02599 Neighboring gene phosducin Neighboring gene STARR-positive B cell enhancer mm9_chr1:152220093-152220393 Neighboring gene STARR-positive B cell enhancer ABC_E4355 Neighboring gene STARR-positive B cell enhancer ABC_E9061 Neighboring gene odr4 GPCR localization factor homolog Neighboring gene STARR-positive B cell enhancer ABC_E2013 Neighboring gene STARR-seq mESC enhancer starr_02600 Neighboring gene STARR-seq mESC enhancer starr_02601 Neighboring gene STARR-seq mESC enhancer starr_02603 Neighboring gene proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) Neighboring gene predicted gene, 41967 Neighboring gene STARR-seq mESC enhancer starr_02604 Neighboring gene spindle and kinetochore associated complex subunit 2-like, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in RNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA import into nucleus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interferon-alpha IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA export from nucleus in response to heat stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic spindle assembly checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of RNA export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitotic sister chromatid separation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to epidermal growth factor ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of cytoplasmic dynein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear periphery ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore ISO
Inferred from Sequence Orthology
more info
 
part_of nuclear pore NAS
Non-traceable Author Statement
more info
PubMed 
part_of nuclear pore nuclear basket ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nucleoprotein TPR
Names
NPC-associated intranuclear protein
nuclear pore complex-associated protein Tpr
translocated promoter region and nuclear basket protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133780.3NP_598541.3  nucleoprotein TPR

    See identical proteins and their annotated locations for NP_598541.3

    Status: VALIDATED

    Source sequence(s)
    AC161432
    Consensus CDS
    CCDS35734.2
    UniProtKB/Swiss-Prot
    F6ZDS4, Q8R4A0, Q921B9
    UniProtKB/TrEMBL
    Q7M739
    Related
    ENSMUSP00000117616.3, ENSMUST00000124973.9
    Conserved Domains (6) summary
    pfam05483
    Location:3631147
    SCP-1; Synaptonemal complex protein 1 (SCP-1)
    TIGR04527
    Location:10391124
    mycoplas_twoTM; two transmembrane protein
    pfam07926
    Location:11121240
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    cl12013
    Location:300446
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl19219
    Location:430575
    DUF342; Protein of unknown function (DUF342)
    cl23720
    Location:902984
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    150268544..150325686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529065.4XP_006529128.1  nucleoprotein TPR isoform X1

    UniProtKB/TrEMBL
    Q7M739
    Conserved Domains (5) summary
    COG1196
    Location:127870
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR00927
    Location:18972135
    2A1904; K+-dependent Na+/Ca+ exchanger
    TIGR02168
    Location:8471687
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05109
    Location:17021936
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam07926
    Location:11101238
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein