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TMPO thymopoietin [ Homo sapiens (human) ]

Gene ID: 7112, updated on 12-Oct-2019

Summary

Official Symbol
TMPOprovided by HGNC
Official Full Name
thymopoietinprovided by HGNC
Primary source
HGNC:HGNC:11875
See related
Ensembl:ENSG00000120802 MIM:188380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TP; LAP2; CMD1T; LEMD4; PRO0868
Summary
Through alternative splicing, this gene encodes several distinct LEM domain containing protein isoforms. LEM domain proteins include inner nuclear membrane and intranuclear proteins, and are involved in a variety of cellular functions including gene expression, chromatin organization, and replication and cell cycle control. The encoded alpha isoform is broadly diffuse in the nucleus and contains a lamin binding domain, while the beta and gamma isoforms are localized to the nuclear membrane and contain an HDAC3 interaction domain. The distinct isoforms may compete with each other when acting to chaperone other proteins and regulate transcription. [provided by RefSeq, Aug 2019]
Expression
Ubiquitous expression in lymph node (RPKM 23.3), bone marrow (RPKM 19.4) and 25 other tissues See more
Orthologs

Genomic context

See TMPO in Genome Data Viewer
Location:
12q23.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (98515573..98550379)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (98909351..98944157)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2453 Neighboring gene tRNA-Asp (anticodon GTC) 1-1 Neighboring gene tRNA-Trp (anticodon CCA) 4-1 Neighboring gene TMPO antisense RNA 1 Neighboring gene peptidylprolyl isomerase A pseudogene 8 Neighboring gene solute carrier family 25 member 3 Neighboring gene small nucleolar RNA, H/ACA box 53

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated lamina-associated polypeptide 2, beta/gamma (LAP2) protein is incorporated into HIV-1 Gag virus-like particles PubMed
Tat tat Interaction of HIV-1 Tat with lamina-associated polypeptide 2 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Clearance of Nuclear Envelope Membranes from Chromatin, organism-specific biosystem (from REACTOME)
    Clearance of Nuclear Envelope Membranes from Chromatin, organism-specific biosystemIn mitotic prophase, chromatin detaches from the nuclear envelope, and this contributes to the nuclear envelope breakdown. VRK1 (and possibly VRK2) mediated phosphorylation of BANF1 (BAF), a protein ...
  • Depolymerisation of the Nuclear Lamina, organism-specific biosystem (from REACTOME)
    Depolymerisation of the Nuclear Lamina, organism-specific biosystemThe nuclear envelope breakdown in mitotic prophase involves depolymerisation of lamin filaments, the main constituents of the nuclear lamina. The nuclear lamina is located at the nuclear face of the ...
  • Initiation of Nuclear Envelope Reformation, organism-specific biosystem (from REACTOME)
    Initiation of Nuclear Envelope Reformation, organism-specific biosystemReassembly of the nuclear envelope is initiated at late anaphase/early telophase when BANF1 (BAF) accumulates on the decondensing chromosome mass close to the spindle ('core' region), together with E...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Anaphase, organism-specific biosystemIn anaphase, the paired chromosomes separate at the centromeres, and move to the opposite sides of the cell. The movement of the chromosomes is facilitated by a combination of kinetochore movement al...
  • Mitotic Metaphase and Anaphase, organism-specific biosystem (from REACTOME)
    Mitotic Metaphase and Anaphase, organism-specific biosystemMetaphase is marked by the formation of the metaphase plate. The metaphase plate is formed when the spindle fibers align the chromosomes along the middle of the cell. Such an organization helps to ...
  • Mitotic Prophase, organism-specific biosystem (from REACTOME)
    Mitotic Prophase, organism-specific biosystemDuring prophase, the chromatin in the nucleus condenses, and the nucleolus disappears. Centrioles begin moving to the opposite poles or sides of the cell. Some of the fibers that extend from the cen...
  • Nuclear Envelope Breakdown, organism-specific biosystem (from REACTOME)
    Nuclear Envelope Breakdown, organism-specific biosystemThe nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelo...
  • Nuclear Envelope Reassembly, organism-specific biosystem (from REACTOME)
    Nuclear Envelope Reassembly, organism-specific biosystemThe reassembly of the nuclear envelope (NE) around separated sister chromatids begins in late anaphase and is completed in telophase. Nuclear pore complexes (NPCs) reassemble and insert into the refo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC61508

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
lamin binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thymopoietin
Names
LEM domain containing 4
lamina-associated polypeptide 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021393.1 RefSeqGene

    Range
    5001..39807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_443

mRNA and Protein(s)

  1. NM_001032283.2NP_001027454.1  thymopoietin isoform beta

    See identical proteins and their annotated locations for NP_001027454.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 3' end compared to variant 1, resulting in a shorter isoform (beta) with a distinct C-terminus compared to isoform alpha.
    Source sequence(s)
    AA992204, AB209297, AI055921, BC053675, BG676381, BM802949, BQ232508, DB239672
    Consensus CDS
    CCDS31879.1
    UniProtKB/Swiss-Prot
    P42167
    UniProtKB/TrEMBL
    A0A024RBE7, Q59G12
    Related
    ENSP00000450627.1, ENST00000556029.5
    Conserved Domains (2) summary
    cd12940
    Location:111139
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:349
    Thymopoietin; Thymopoietin protein
  2. NM_001032284.3NP_001027455.1  thymopoietin isoform gamma

    See identical proteins and their annotated locations for NP_001027455.1

    Status: REVIEWED

    Description
    Transcript Variant: This (3) differs at the 3' end compared to variant 1, resulting in a shorter isoform (gamma) with a distinct C-terminus compared to isoform alpha.
    Source sequence(s)
    AA992204, AB209297, AI055921, BG676381, BM802949, BQ232508, DB239672, U09088
    Consensus CDS
    CCDS31880.1
    UniProtKB/Swiss-Prot
    P42167
    UniProtKB/TrEMBL
    A0A024RBH7, Q59G12
    Related
    ENSP00000376773.2, ENST00000393053.6
    Conserved Domains (2) summary
    cd12940
    Location:111139
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:249
    Thymopoietin; Thymopoietin protein
  3. NM_001307975.2NP_001294904.1  thymopoietin isoform delta

    See identical proteins and their annotated locations for NP_001294904.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs at the 3' end compared to variant 1, resulting in a shorter isoform (delta) with a distinct C-terminus compared to isoform alpha.
    Source sequence(s)
    AA992204, AC013418, BC050383, BC053675, DB239672
    Consensus CDS
    CCDS76589.1
    UniProtKB/Swiss-Prot
    P42167
    UniProtKB/TrEMBL
    G5E972
    Related
    ENSP00000340251.5, ENST00000343315.9
    Conserved Domains (2) summary
    cd12940
    Location:111139
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:249
    Thymopoietin; Thymopoietin protein
  4. NM_003276.2NP_003267.1  thymopoietin isoform alpha

    See identical proteins and their annotated locations for NP_003267.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (alpha).
    Source sequence(s)
    BM991833, BP423544, BU932961, DB239672, U09086
    Consensus CDS
    CCDS9064.1
    UniProtKB/Swiss-Prot
    P42166
    Related
    ENSP00000266732.4, ENST00000266732.8
    Conserved Domains (3) summary
    cd12940
    Location:111139
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:249
    Thymopoietin; Thymopoietin protein
    pfam11560
    Location:461693
    LAP2alpha; Lamina-associated polypeptide 2 alpha

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    98515573..98550379
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269132.4XP_005269189.1  thymopoietin isoform X2

    Conserved Domains (2) summary
    cd12940
    Location:111139
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:249
    Thymopoietin; Thymopoietin protein
  2. XM_017019914.2XP_016875403.1  thymopoietin isoform X1

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