U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tmpo thymopoietin [ Mus musculus (house mouse) ]

Gene ID: 21917, updated on 26-Sep-2022

Summary

Official Symbol
Tmpoprovided by MGI
Official Full Name
thymopoietinprovided by MGI
Primary source
MGI:MGI:106920
See related
Ensembl:ENSMUSG00000019961 AllianceGenome:MGI:106920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TP; LAP2; 5630400D24Rik
Summary
Enables identical protein binding activity. Acts upstream of or within regulation of transcription, DNA-templated. Located in nuclear envelope. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human TMPO (thymopoietin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 41.2), limb E14.5 (RPKM 32.4) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tmpo in Genome Data Viewer
Location:
10 C2; 10 45.66 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (90983433..91017614, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (91147571..91181752, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene apoptotic peptidase activating factor 1 Neighboring gene IKBKB interacting protein Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 Neighboring gene predicted gene, 24119 Neighboring gene nuclear encoded tRNA aspartic acid 16 (anticodon GTC) Neighboring gene nuclear encoded tRNA trytophan 2 (anticodon CCA) Neighboring gene RIKEN cDNA 4930534H03 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
lamina-associated polypeptide 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080129.2NP_001073598.1  lamina-associated polypeptide 2 isoform epsilon

    See identical proteins and their annotated locations for NP_001073598.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains most exons of this gene and encodes isoform (epsilon).
    Source sequence(s)
    AA177175, AC140410, AK165851, CJ071529
    Consensus CDS
    CCDS36035.1
    UniProtKB/Swiss-Prot
    Q61029, Q61032
    Related
    ENSMUSP00000072092.8, ENSMUST00000072239.14
    Conserved Domains (2) summary
    cd12940
    Location:110138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:249
    Thymopoietin; Thymopoietin protein
  2. NM_001080130.2NP_001073599.1  lamina-associated polypeptide 2 isoform delta

    See identical proteins and their annotated locations for NP_001073599.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 3. The resulting isoform (delta) lacks an internal segment, compared to isoform epsilon.
    Source sequence(s)
    AA177175, AC140410, AK165282, CJ071529
    Consensus CDS
    CCDS36034.1
    UniProtKB/TrEMBL
    Q3TNH0
    Related
    ENSMUSP00000089864.7, ENSMUST00000092219.14
    Conserved Domains (2) summary
    cd12940
    Location:110138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:249
    Thymopoietin; Thymopoietin protein
  3. NM_001080131.2NP_001073600.1  lamina-associated polypeptide 2 isoform gamma

    See identical proteins and their annotated locations for NP_001073600.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the coding region, compared to variant 3. The resulting isoform (gamma) lacks an internal segment, compared to isoform epsilon.
    Source sequence(s)
    AA177175, AC140410, AK165851, CJ071529
    Consensus CDS
    CCDS36033.1
    UniProtKB/Swiss-Prot
    Q61029
    Related
    ENSMUSP00000096956.5, ENSMUST00000099355.12
    Conserved Domains (2) summary
    cd12940
    Location:110138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:249
    Thymopoietin; Thymopoietin protein
  4. NM_001080132.2NP_001073601.1  lamina-associated polypeptide 2 isoform beta

    See identical proteins and their annotated locations for NP_001073601.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three consecutive in-frame exons in the coding region, compared to variant 3. The resulting isoform (beta) lacks an internal segment, compared to isoform epsilon.
    Source sequence(s)
    AA177175, AC140410, AK165851, CJ071529
    Consensus CDS
    CCDS36032.1
    UniProtKB/Swiss-Prot
    Q61029
    Related
    ENSMUSP00000100930.4, ENSMUST00000105293.11
    Conserved Domains (2) summary
    cd12940
    Location:110138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:249
    Thymopoietin; Thymopoietin protein
  5. NM_001283048.1NP_001269977.1  lamina-associated polypeptide 2 isoform omega

    See identical proteins and their annotated locations for NP_001269977.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 3. The resulting isoform (omega) has a much shorter N-terminus, compared to isoform epsilon.
    Source sequence(s)
    AA177175, AC140410, AK159161, BY103202
    UniProtKB/TrEMBL
    Q3TXQ1
    Conserved Domains (1) summary
    COG1426
    Location:2699
    RodZ; Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]
  6. NM_011605.3NP_035735.2  lamina-associated polypeptide 2 isoform alpha

    See identical proteins and their annotated locations for NP_035735.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks several exons but has an alternate 3' terminal exon, compared to variant 3. The resulting isoform (alpha) is longer and has a distinct C-terminus, compared to isoform epsilon.
    Source sequence(s)
    AK144642, AK156206, AV450597, BC141062, CJ071529
    Consensus CDS
    CCDS24122.1
    UniProtKB/Swiss-Prot
    Q61028, Q61033
    Related
    ENSMUSP00000020123.6, ENSMUST00000020123.7
    Conserved Domains (3) summary
    cd12940
    Location:110138
    LEM_LAP2_LEMD1; LEM (Lap2/Emerin/Man1) domain found in lamina-associated polypeptide 2 (LAP2), LEM domain-containing protein 1 (LEMP-1) and similar proteins
    pfam08198
    Location:249
    Thymopoietin; Thymopoietin protein
    pfam11560
    Location:459692
    LAP2alpha; Lamina-associated polypeptide 2 alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    90983433..91017614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245061.1XP_030100921.1  lamina-associated polypeptide 2 isoform X1

    UniProtKB/TrEMBL
    Q3TXQ1
    Conserved Domains (1) summary
    COG1426
    Location:2699
    RodZ; Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]
  2. XM_006513590.4XP_006513653.1  lamina-associated polypeptide 2 isoform X1

    See identical proteins and their annotated locations for XP_006513653.1

    UniProtKB/TrEMBL
    Q3TXQ1
    Conserved Domains (1) summary
    COG1426
    Location:2699
    RodZ; Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080134.1: Suppressed sequence

    Description
    NM_001080134.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.