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TLN1 talin 1 [ Homo sapiens (human) ]

Gene ID: 7094, updated on 1-Jun-2020

Summary

Official Symbol
TLN1provided by HGNC
Official Full Name
talin 1provided by HGNC
Primary source
HGNC:HGNC:11845
See related
Ensembl:ENSG00000137076 MIM:186745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TLN; ILWEQ; talin-1
Summary
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
Expression
Ubiquitous expression in fat (RPKM 74.7), spleen (RPKM 60.6) and 25 other tissues See more
Orthologs

Genomic context

See TLN1 in Genome Data Viewer
Location:
9p13.3
Exon count:
57
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35696948..35732195, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35697334..35732392, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 9 Neighboring gene skeletal muscle cis-regulatory module in TPM2 intron Neighboring gene tropomyosin 2 Neighboring gene microRNA 6852 Neighboring gene microRNA 6853 Neighboring gene cAMP responsive element binding protein 3 Neighboring gene glucosylceramidase beta 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of total serum and mite-specific IgEs in asthma patients.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
matrix gag HIV-1 MA co-localizes with beta2 integrin, alphaM and alphaX integrins in the intracellular thick electron-dense membrane compartments, which contain talin, vinculin and paxillin that connect the integrin complexes to the actin cytoskeleton PubMed
retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1027

Gene Ontology Provided by GOA

Function Evidence Code Pubs
LIM domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylserine binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
vinculin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
 
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell junction assembly TAS
Traceable Author Statement
more info
PubMed 
cell-substrate junction assembly IEA
Inferred from Electronic Annotation
more info
 
cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
integrin activation IEA
Inferred from Electronic Annotation
more info
 
integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
muscle contraction TAS
Traceable Author Statement
more info
 
platelet aggregation HMP PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
adherens junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
focal adhesion NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle ISS
Inferred from Sequence or Structural Similarity
more info
 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006289.4NP_006280.3  talin-1

    See identical proteins and their annotated locations for NP_006280.3

    Status: REVIEWED

    Source sequence(s)
    AB028950, AL133410
    Consensus CDS
    CCDS35009.1
    UniProtKB/Swiss-Prot
    Q9Y490
    Related
    ENSP00000316029.9, ENST00000314888.10
    Conserved Domains (10) summary
    cd12150
    Location:16541826
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:88313
    B41; Band 4.1 homologues
    smart00307
    Location:23362532
    ILWEQ; I/LWEQ domain
    cd10569
    Location:309400
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:204313
    FERM_M; FERM central domain
    pfam08913
    Location:18491973
    VBS; Vinculin Binding Site
    pfam09141
    Location:491652
    Talin_middle; Talin, middle domain
    pfam09379
    Location:90186
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:483
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:822912
    I_LWEQ; I/LWEQ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    35696948..35732195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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