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Tln1 talin 1 [ Mus musculus (house mouse) ]

Gene ID: 21894, updated on 12-May-2024

Summary

Official Symbol
Tln1provided by MGI
Official Full Name
talin 1provided by MGI
Primary source
MGI:MGI:1099832
See related
Ensembl:ENSMUSG00000028465 AllianceGenome:MGI:1099832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tln
Summary
Enables integrin binding activity; phosphatidylinositol binding activity; and phosphatidylserine binding activity. Involved in integrin activation and integrin-mediated signaling pathway. Acts upstream of or within cell-substrate junction assembly and cortical actin cytoskeleton organization. Located in focal adhesion. Is expressed in several structures, including body cavity or lining; cardiovascular system; neural plate; submandibular gland; and vertebral axis musculature. Orthologous to human TLN1 (talin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 86.9), ovary adult (RPKM 82.7) and 28 other tissues See more
Orthologs
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Genomic context

See Tln1 in Genome Data Viewer
Location:
4 A5; 4 23.05 cM
Exon count:
60
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43531513..43562583, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43531513..43562583, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 39 Neighboring gene carbonic anhydrase 9 Neighboring gene STARR-positive B cell enhancer ABC_E9584 Neighboring gene tropomyosin 2, beta Neighboring gene STARR-seq mESC enhancer starr_10056 Neighboring gene cAMP responsive element binding protein 3 Neighboring gene glucosidase beta 2 Neighboring gene RAB6A GEF compex partner 1 Neighboring gene microseminoprotein, prostate associated

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables LIM domain binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables integrin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphatidylserine binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
enables vinculin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell-substrate junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cortical actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ruffle IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011602.5NP_035732.2  talin-1

    See identical proteins and their annotated locations for NP_035732.2

    Status: VALIDATED

    Source sequence(s)
    AK122420, AK147228, AL732506, BC121787, CJ242702
    Consensus CDS
    CCDS18101.1
    UniProtKB/Swiss-Prot
    A2AIM8, P26039, Q8VEF0
    UniProtKB/TrEMBL
    Q3UHS6
    Related
    ENSMUSP00000030187.8, ENSMUST00000030187.14
    Conserved Domains (10) summary
    cd12150
    Location:16541826
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:88313
    B41; Band 4.1 homologues
    smart00307
    Location:23362532
    ILWEQ; I/LWEQ domain
    cd10569
    Location:309400
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam00373
    Location:204313
    FERM_M; FERM central domain
    pfam08913
    Location:18491973
    VBS; Vinculin Binding Site
    pfam09141
    Location:491652
    Talin_middle; Talin, middle domain
    pfam09379
    Location:90186
    FERM_N; FERM N-terminal domain
    pfam16511
    Location:483
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl19756
    Location:822912
    I_LWEQ; I/LWEQ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43531513..43562583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537770.4XP_006537833.1  talin-1 isoform X3

    See identical proteins and their annotated locations for XP_006537833.1

    UniProtKB/TrEMBL
    Q3UHS6
    Conserved Domains (9) summary
    cd12150
    Location:16711843
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:88313
    B41; Band 4.1 homologues
    smart00307
    Location:23532549
    ILWEQ; I/LWEQ domain
    cd10569
    Location:309400
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:18661990
    VBS; Vinculin Binding Site
    cd17171
    Location:285
    FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
    cd17173
    Location:86197
    FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
    pfam09141
    Location:491652
    Talin_middle; Talin, middle domain
    cl19756
    Location:839935
    I_LWEQ; I/LWEQ domain
  2. XM_006537769.4XP_006537832.3  talin-1 isoform X2

    UniProtKB/TrEMBL
    Q80TM2
    Conserved Domains (9) summary
    cd12150
    Location:17231895
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:157382
    B41; Band 4.1 homologues
    smart00307
    Location:24052601
    ILWEQ; I/LWEQ domain
    cd10569
    Location:378469
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:19182042
    VBS; Vinculin Binding Site
    cd17171
    Location:71154
    FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
    cd17173
    Location:155266
    FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
    pfam09141
    Location:560721
    Talin_middle; Talin, middle domain
    cl19756
    Location:891987
    I_LWEQ; I/LWEQ domain
  3. XM_006537768.4XP_006537831.3  talin-1 isoform X1

    UniProtKB/TrEMBL
    Q80TM2
    Conserved Domains (9) summary
    cd12150
    Location:17401912
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:157382
    B41; Band 4.1 homologues
    smart00307
    Location:24222618
    ILWEQ; I/LWEQ domain
    cd10569
    Location:378469
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:19352059
    VBS; Vinculin Binding Site
    cd17171
    Location:71154
    FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
    cd17173
    Location:155266
    FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
    pfam09141
    Location:560721
    Talin_middle; Talin, middle domain
    cl19756
    Location:9081004
    I_LWEQ; I/LWEQ domain
  4. XM_036163963.1XP_036019856.1  talin-1 isoform X5

    UniProtKB/TrEMBL
    Q3UHS6
    Conserved Domains (7) summary
    cd12150
    Location:13831555
    talin-RS; rod-segment of the talin C-terminal domain
    smart00307
    Location:20652261
    ILWEQ; I/LWEQ domain
    cd10569
    Location:21112
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:15781702
    VBS; Vinculin Binding Site
    pfam09141
    Location:203364
    Talin_middle; Talin, middle domain
    cl09511
    Location:125
    FERM_B-lobe; FERM domain B-lobe
    cl19756
    Location:551647
    I_LWEQ; I/LWEQ domain
  5. XM_036163962.1XP_036019855.1  talin-1 isoform X4

    UniProtKB/TrEMBL
    Q80TM2
    Conserved Domains (8) summary
    cd12150
    Location:17401912
    talin-RS; rod-segment of the talin C-terminal domain
    smart00295
    Location:157382
    B41; Band 4.1 homologues
    cd10569
    Location:378469
    FERM_C_Talin; FERM domain C-lobe/F3 of Talin
    pfam08913
    Location:19352059
    VBS; Vinculin Binding Site
    cd17171
    Location:71154
    FERM_F0_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in Talin-1 (TLN1)
    cd17173
    Location:155266
    FERM_F1_TLN1; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in Talin-1 (TLN1)
    pfam09141
    Location:560721
    Talin_middle; Talin, middle domain
    cl19756
    Location:9081004
    I_LWEQ; I/LWEQ domain