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TFDP2 transcription factor Dp-2 [ Homo sapiens (human) ]

Gene ID: 7029, updated on 9-Aug-2020

Summary

Official Symbol
TFDP2provided by HGNC
Official Full Name
transcription factor Dp-2provided by HGNC
Primary source
HGNC:HGNC:11751
See related
Ensembl:ENSG00000114126 MIM:602160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP2
Summary
The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in ovary (RPKM 7.2), testis (RPKM 6.9) and 25 other tissues See more
Orthologs

Genomic context

See TFDP2 in Genome Data Viewer
Location:
3q23
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (141944428..142149544, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141663270..141868386, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 25 Neighboring gene ATPase Na+/K+ transporting subunit beta 3 Neighboring gene RNA, U6 small nuclear 509, pseudogene Neighboring gene ribosomal protein L19 pseudogene 6 Neighboring gene RNA, U6 small nuclear 425, pseudogene Neighboring gene glycerol kinase 5 Neighboring gene Sharpr-MPRA regulatory region 12219

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transcription factor Dp-2 (E2F dimerization partner 2; TFDP2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39131, DKFZp313O196

Gene Ontology Provided by GOA

Component Evidence Code Pubs
RNA polymerase II transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor Dp-2
Names
transcription factor Dp-2 (E2F dimerization partner 2)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001178138.2NP_001171609.1  transcription factor Dp-2 isoform 1

    See identical proteins and their annotated locations for NP_001171609.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, BC013993, BC040991, DA321332
    Consensus CDS
    CCDS43159.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000418590.1, ENST00000467072.5
    Conserved Domains (3) summary
    cd14458
    Location:153199
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:67148
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:155293
    DP; Transcription factor DP
  2. NM_001178139.2NP_001171610.1  transcription factor Dp-2 isoform 2

    See identical proteins and their annotated locations for NP_001171610.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AC133435, AK314786, BC013993, BC040991, DA321332
    Consensus CDS
    CCDS54650.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000420616.1, ENST00000489671.5
    Conserved Domains (3) summary
    cd14458
    Location:213259
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:128208
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:215353
    DP; Transcription factor DP
  3. NM_001178140.2NP_001171611.1  transcription factor Dp-2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648
    Consensus CDS
    CCDS54648.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000439782.2, ENST00000499676.5
    Conserved Domains (3) summary
    cd14458
    Location:185231
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:100180
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:187325
    DP; Transcription factor DP
  4. NM_001178141.2NP_001171612.1  transcription factor Dp-2 isoform 4

    See identical proteins and their annotated locations for NP_001171612.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, AK303634, BC040991, DC319314
    Consensus CDS
    CCDS54649.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000419036.1, ENST00000495310.5
    Conserved Domains (3) summary
    cd14458
    Location:116162
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:31111
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:118256
    DP; Transcription factor DP
  5. NM_001178142.2NP_001171613.1  transcription factor Dp-2 isoform 5

    See identical proteins and their annotated locations for NP_001171613.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AK303181, BC040991
    Consensus CDS
    CCDS54647.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000418971.1, ENST00000477292.5
    Conserved Domains (3) summary
    cd14458
    Location:77123
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:172
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:79217
    DP; Transcription factor DP
  6. NM_001375756.1NP_001362685.1  transcription factor Dp-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AC133435
    Related
    ENSP00000417585.1, ENST00000479040.5
  7. NM_001375773.1NP_001362702.1  transcription factor Dp-2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
  8. NM_001375774.1NP_001362703.1  transcription factor Dp-2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AC133435
  9. NM_001375775.1NP_001362704.1  transcription factor Dp-2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
  10. NM_001375776.1NP_001362705.1  transcription factor Dp-2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
  11. NM_001375778.1NP_001362707.1  transcription factor Dp-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
  12. NM_001375779.1NP_001362708.1  transcription factor Dp-2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AC133435
  13. NM_001375780.1NP_001362709.1  transcription factor Dp-2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
  14. NM_006286.5NP_006277.1  transcription factor Dp-2 isoform 1

    See identical proteins and their annotated locations for NP_006277.1

    Status: REVIEWED

    Description
    Transcript Variant:).
    Source sequence(s)
    AC112504, BC040991, DC319314, U18422
    Consensus CDS
    CCDS43159.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000420599.1, ENST00000486111.5
    Conserved Domains (3) summary
    cd14458
    Location:153199
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:67148
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:155293
    DP; Transcription factor DP

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    141944428..142149544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007100.2XP_016862589.1  transcription factor Dp-2 isoform X9

  2. XM_011513107.2XP_011511409.1  transcription factor Dp-2 isoform X8

    Conserved Domains (3) summary
    cd14458
    Location:214260
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129209
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:216352
    DP; Transcription factor DP
  3. XM_017007091.1XP_016862580.1  transcription factor Dp-2 isoform X2

    UniProtKB/Swiss-Prot
    Q14188
    Conserved Domains (3) summary
    cd14458
    Location:213259
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:128208
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:215353
    DP; Transcription factor DP
  4. XM_011513101.3XP_011511403.1  transcription factor Dp-2 isoform X4

    See identical proteins and their annotated locations for XP_011511403.1

    Conserved Domains (3) summary
    cd14458
    Location:192238
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:106187
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:194332
    DP; Transcription factor DP
  5. XM_024453730.1XP_024309498.1  transcription factor Dp-2 isoform X10

    Conserved Domains (3) summary
    cd14458
    Location:101147
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:1596
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:103241
    DP; Transcription factor DP
  6. XM_024453728.1XP_024309496.1  transcription factor Dp-2 isoform X5

    Conserved Domains (3) summary
    cd14458
    Location:191237
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:106186
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:193331
    DP; Transcription factor DP
  7. XM_024453726.1XP_024309494.1  transcription factor Dp-2 isoform X4

    Conserved Domains (3) summary
    cd14458
    Location:192238
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:106187
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:194332
    DP; Transcription factor DP
  8. XM_017007104.2XP_016862593.1  transcription factor Dp-2 isoform X12

  9. XM_011513108.3XP_011511410.1  transcription factor Dp-2 isoform X10

    See identical proteins and their annotated locations for XP_011511410.1

    Conserved Domains (3) summary
    cd14458
    Location:101147
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:1596
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:103241
    DP; Transcription factor DP
  10. XM_011513102.2XP_011511404.1  transcription factor Dp-2 isoform X4

    See identical proteins and their annotated locations for XP_011511404.1

    Conserved Domains (3) summary
    cd14458
    Location:192238
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:106187
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:194332
    DP; Transcription factor DP
  11. XM_011513109.2XP_011511411.1  transcription factor Dp-2 isoform X10

    See identical proteins and their annotated locations for XP_011511411.1

    Conserved Domains (3) summary
    cd14458
    Location:101147
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:1596
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:103241
    DP; Transcription factor DP
  12. XM_024453727.1XP_024309495.1  transcription factor Dp-2 isoform X4

    Conserved Domains (3) summary
    cd14458
    Location:192238
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:106187
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:194332
    DP; Transcription factor DP
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