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TFDP2 transcription factor Dp-2 [ Homo sapiens (human) ]

Gene ID: 7029, updated on 26-Oct-2022

Summary

Official Symbol
TFDP2provided by HGNC
Official Full Name
transcription factor Dp-2provided by HGNC
Primary source
HGNC:HGNC:11751
See related
Ensembl:ENSG00000114126 MIM:602160; AllianceGenome:HGNC:11751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP2
Summary
The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in ovary (RPKM 7.2), testis (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

See TFDP2 in Genome Data Viewer
Location:
3q23
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (141944428..142149544, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (144691750..144896843, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (141663270..141868386, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit beta 3 Neighboring gene RNA, U6 small nuclear 509, pseudogene Neighboring gene uncharacterized LOC124909442 Neighboring gene Sharpr-MPRA regulatory region 4576 Neighboring gene ribosomal protein L19 pseudogene 6 Neighboring gene RNA, U6 small nuclear 425, pseudogene Neighboring gene glycerol kinase 5 Neighboring gene Sharpr-MPRA regulatory region 12219

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transcription factor Dp-2 (E2F dimerization partner 2; TFDP2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ39131, DKFZp313O196

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcription factor Dp-2
Names
transcription factor Dp-2 (E2F dimerization partner 2)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001178138.2NP_001171609.1  transcription factor Dp-2 isoform 1

    See identical proteins and their annotated locations for NP_001171609.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, BC013993, BC040991, DA321332
    Consensus CDS
    CCDS43159.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000418590.1, ENST00000467072.5
    Conserved Domains (3) summary
    cd14458
    Location:153199
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:68148
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:155293
    DP; Transcription factor DP
  2. NM_001178139.2NP_001171610.1  transcription factor Dp-2 isoform 2

    See identical proteins and their annotated locations for NP_001171610.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AC133435, AK314786, BC013993, BC040991, DA321332
    Consensus CDS
    CCDS54650.1
    UniProtKB/Swiss-Prot
    Q14188, Q9UG28
    Related
    ENSP00000420616.1, ENST00000489671.6
    Conserved Domains (3) summary
    cd14458
    Location:213259
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129208
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:215353
    DP; Transcription factor DP
  3. NM_001178140.2NP_001171611.1  transcription factor Dp-2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648
    Consensus CDS
    CCDS54648.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000439782.2, ENST00000499676.5
    Conserved Domains (3) summary
    cd14458
    Location:185231
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:100180
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:187325
    DP; Transcription factor DP
  4. NM_001178141.2NP_001171612.1  transcription factor Dp-2 isoform 4

    See identical proteins and their annotated locations for NP_001171612.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, AK303634, BC040991, DC319314
    Consensus CDS
    CCDS54649.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000419036.1, ENST00000495310.5
    Conserved Domains (2) summary
    pfam02319
    Location:32111
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:118256
    DP; Transcription factor DP
  5. NM_001178142.2NP_001171613.1  transcription factor Dp-2 isoform 5

    See identical proteins and their annotated locations for NP_001171613.1

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AK303181, BC040991
    Consensus CDS
    CCDS54647.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000418971.1, ENST00000477292.5
    Conserved Domains (3) summary
    cd14458
    Location:77123
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:172
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:79217
    DP; Transcription factor DP
  6. NM_001375756.1NP_001362685.1  transcription factor Dp-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AC133435
    Consensus CDS
    CCDS93401.1
    Related
    ENSP00000417585.1, ENST00000479040.5
    Conserved Domains (3) summary
    cd14458
    Location:152198
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:68147
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:154292
    DP; Transcription factor DP
  7. NM_001375773.1NP_001362702.1  transcription factor Dp-2 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
    Conserved Domains (3) summary
    cd14458
    Location:214260
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129209
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:216354
    DP; Transcription factor DP
  8. NM_001375774.1NP_001362703.1  transcription factor Dp-2 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AC133435
    Conserved Domains (3) summary
    cd14458
    Location:196242
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:111191
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:198336
    DP; Transcription factor DP
  9. NM_001375775.1NP_001362704.1  transcription factor Dp-2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
    Conserved Domains (3) summary
    cd14458
    Location:191237
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:107186
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:193331
    DP; Transcription factor DP
  10. NM_001375776.1NP_001362705.1  transcription factor Dp-2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
    Consensus CDS
    CCDS43159.1
    Conserved Domains (3) summary
    cd14458
    Location:153199
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:68148
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:155293
    DP; Transcription factor DP
  11. NM_001375778.1NP_001362707.1  transcription factor Dp-2 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
    Consensus CDS
    CCDS93401.1
    Conserved Domains (3) summary
    cd14458
    Location:152198
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:68147
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:154292
    DP; Transcription factor DP
  12. NM_001375779.1NP_001362708.1  transcription factor Dp-2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC112504, AC128648, AC133435
    Conserved Domains (3) summary
    cd14458
    Location:100146
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:1695
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:102240
    DP; Transcription factor DP
  13. NM_001375780.1NP_001362709.1  transcription factor Dp-2 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC108679, AC112504, AC128648, AC133435
    Conserved Domains (3) summary
    cd14458
    Location:100146
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:1695
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:102240
    DP; Transcription factor DP
  14. NM_006286.5NP_006277.1  transcription factor Dp-2 isoform 1

    See identical proteins and their annotated locations for NP_006277.1

    Status: REVIEWED

    Description
    Transcript Variant:).
    Source sequence(s)
    AC112504, BC040991, DC319314, U18422
    Consensus CDS
    CCDS43159.1
    UniProtKB/Swiss-Prot
    Q14188
    Related
    ENSP00000420599.1, ENST00000486111.5
    Conserved Domains (3) summary
    cd14458
    Location:153199
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:68148
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:155293
    DP; Transcription factor DP

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    141944428..142149544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007100.3XP_016862589.1  transcription factor Dp-2 isoform X9

  2. XM_011513107.3XP_011511409.1  transcription factor Dp-2 isoform X8

    Conserved Domains (3) summary
    cd14458
    Location:214260
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129209
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:216352
    DP; Transcription factor DP
  3. XM_047448783.1XP_047304739.1  transcription factor Dp-2 isoform X9

  4. XM_017007091.2XP_016862580.1  transcription factor Dp-2 isoform X2

    UniProtKB/Swiss-Prot
    Q14188, Q9UG28
    Conserved Domains (3) summary
    cd14458
    Location:213259
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129208
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:215353
    DP; Transcription factor DP
  5. XM_047448775.1XP_047304731.1  transcription factor Dp-2 isoform X1

  6. XM_047448779.1XP_047304735.1  transcription factor Dp-2 isoform X4

  7. XM_047448785.1XP_047304741.1  transcription factor Dp-2 isoform X11

  8. XM_047448784.1XP_047304740.1  transcription factor Dp-2 isoform X10

  9. XM_047448782.1XP_047304738.1  transcription factor Dp-2 isoform X7

  10. XM_047448781.1XP_047304737.1  transcription factor Dp-2 isoform X6

  11. XM_047448780.1XP_047304736.1  transcription factor Dp-2 isoform X5

  12. XM_047448777.1XP_047304733.1  transcription factor Dp-2 isoform X4

  13. XM_047448776.1XP_047304732.1  transcription factor Dp-2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    144691750..144896843 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)