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TCOF1 treacle ribosome biogenesis factor 1 [ Homo sapiens (human) ]

Gene ID: 6949, updated on 6-Jul-2026
Official Symbol
TCOF1provided by HGNC
Official Full Name
treacle ribosome biogenesis factor 1provided by HGNC
Primary source
HGNC:HGNC:11654
See related
Ensembl:ENSG00000070814 MIM:606847; AllianceGenome:HGNC:11654
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCS; MFD1; TCS1; treacle
Summary
This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in lymph node (RPKM 7.8), appendix (RPKM 6.8) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See TCOF1 in Genome Data Viewer
Location:
5q32-q33.1
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (150357697..150400293)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (150894238..150936834)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (149737260..149779856)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23400 Neighboring gene uncharacterized LOC105378226 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82342 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:149755228-149755750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149756274-149756796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23401 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23413 Neighboring gene CD74 molecule Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:149792263-149792832 Neighboring gene uncharacterized LOC124901106

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Facial asymmetry and clinical manifestations in patients with novel insertion of the TCOF1 gene. Su PH, et al. Clin Genet, 2012 Nov. PMID 21848650
  2. Another face of the Treacher Collins syndrome (TCOF1) gene: identification of additional exons. So RB, et al. Gene, 2004 Mar 17. PMID 15019983
  3. Mosaicism of a TCOF1 mutation in an individual clinically unaffected with Treacher Collins syndrome. Shoo BA, et al. Am J Med Genet A, 2004 Apr 1. PMID 15039977
  4. [TCOF1 Gene variation in Treacher Collins syndrome and evaluation of speech rehabilitation after bone bridge surgery]. Li Y, et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2023 Sep. PMID 37640998, Free PMC Article
  5. Genotyping in 46 patients with tentative diagnosis of Treacher Collins syndrome revealed unexpected phenotypic variation. Teber OA, et al. Eur J Hum Genet, 2004 Nov. PMID 15340364

See all (255) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis.
    Title: Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis.
  2. [Diagnosis of a Chinese pedigree affected with Treacher-Collins syndrome due to a novel variant of TCOF1 gene through whole exome sequencing].
    Title: [Diagnosis of a Chinese pedigree affected with Treacher-Collins syndrome due to a novel variant of TCOF1 gene through whole exome sequencing].
  3. The transcription of the main gene associated with Treacher-Collins syndrome (TCOF1) is regulated by G-quadruplexes and cellular nucleic acid binding protein (CNBP).
    Title: The transcription of the main gene associated with Treacher-Collins syndrome (TCOF1) is regulated by G-quadruplexes and cellular nucleic acid binding protein (CNBP).
  4. A novel intronic TCOF1 pathogenic variant in a Chinese family with Treacher Collins syndrome.
    Title: A novel intronic TCOF1 pathogenic variant in a Chinese family with Treacher Collins syndrome.
  5. Two novel pathogenic variants in the TCOF1 found in two Chinese cases of Treacher Collins syndrome.
    Title: Two novel pathogenic variants in the TCOF1 found in two Chinese cases of Treacher Collins syndrome.
  6. [TCOF1 Gene variation in Treacher Collins syndrome and evaluation of speech rehabilitation after bone bridge surgery].
    Title: [TCOF1 Gene variation in Treacher Collins syndrome and evaluation of speech rehabilitation after bone bridge surgery].
  7. Genetic mutations in ribosomal biogenesis gene TCOF1 identified in human neural tube defects.
    Title: Genetic mutations in ribosomal biogenesis gene TCOF1 identified in human neural tube defects.
  8. The oncogenic role of treacle ribosome biogenesis factor 1 (TCOF1) in human tumors: a pan-cancer analysis.
    Title: The oncogenic role of treacle ribosome biogenesis factor 1 (TCOF1) in human tumors: a pan-cancer analysis.
  9. TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis.
    Title: TCOF1 upregulation in triple-negative breast cancer promotes stemness and tumour growth and correlates with poor prognosis.
  10. TCOF1 coordinates oncogenic activation and rRNA production and promotes tumorigenesis in HCC.
    Title: TCOF1 coordinates oncogenic activation and rRNA production and promotes tumorigenesis in HCC.
Submit: New GeneRIF Correction See all GeneRIFs (47)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Treacher Collins syndrome 1
MedGen: CN315775 OMIM: 154500 GeneReviews: Treacher Collins Syndrome
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2021-04-28)

ClinGen Genome Curation PagePubMed
Triplosensitivity

No evidence available (Last evaluated 2021-04-28)

ClinGen Genome Curation Page

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with TCOF1 as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables scaffold protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables scaffold protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in neural crest cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neural crest cell development NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in neural crest formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleolar large rRNA transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in skeletal system development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus TAS
Traceable Author Statement
more info
 PubMed 
Preferred Names
treacle protein
Names
Treacher Collins syndrome protein
Treacher Collins-Franceschetti syndrome 1
nucleolar trafficking phosphoprotein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011341.1 RefSeqGene

    Range
    5059..47655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000356.4 → NP_000347.2  treacle protein isoform b

    See identical proteins and their annotated locations for NP_000347.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the alternate in-frame exon 7, also known as VIa, in the 5' coding region, compared to variant 4. The resulting isoform (b) lacks an internal segment but has the same N- and C-termini, compared to isoform d.
    Source sequence(s)
    BC016144, BM664489, U76366
    Consensus CDS
    CCDS4306.1
    UniProtKB/TrEMBL
    A0ACI8TJA9
    Related
    ENSP00000325223.6, ENST00000323668.11
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:239 → 827
    Treacle; Treacher Collins syndrome protein Treacle

  2. NM_001008657.3 → NP_001008657.1  treacle protein isoform c

    See identical proteins and their annotated locations for NP_001008657.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate terminal exon and lacks 10 3' exons, compared to variant 4. The resulting isoform (c) has a significantly shorter and distinct C-terminus, compared to isoform d.
    Source sequence(s)
    AC011372, AI939467, AW135418, BC011764
    Consensus CDS
    CCDS47307.1
    UniProtKB/TrEMBL
    H0Y8Y7
    Related
    ENSP00000377811.3, ENST00000394269.7
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:316 → 904
    Treacle; Treacher Collins syndrome protein Treacle

  3. NM_001135243.2 → NP_001128715.1  treacle protein isoform d

    See identical proteins and their annotated locations for NP_001128715.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AC011372, AY460334, BC016144, BM664489, U76366
    Consensus CDS
    CCDS54936.1
    UniProtKB/Swiss-Prot
    A0JLU0, B4E111, Q13428, Q6SC72, Q7Z5W9, Q96A52, Q99408, Q99860
    UniProtKB/TrEMBL
    A0ACI8TJC6
    Related
    ENSP00000367028.4, ENST00000377797.7
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:316 → 904
    Treacle; Treacher Collins syndrome protein Treacle

  4. NM_001135244.2 → NP_001128716.1  treacle protein isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks the alternate in-frame exon 21, also known as XIX, and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (e) lacks an internal segment, contains a one residue insertion, and has the same N- and C-termini, compared to isoform d.
    Source sequence(s)
    AC011372, AK303611, BC016144, BM664489, U76366
    Consensus CDS
    CCDS47305.1
    UniProtKB/TrEMBL
    A0ACI8TJZ6
    Related
    ENSP00000406888.2, ENST00000439160.6
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:316 → 904
    Treacle; Treacher Collins syndrome protein Treacle

  5. NM_001135245.2 → NP_001128717.1  treacle protein isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks the alternate in-frame exon 7, also known as VIa, in the 5' coding region and uses an alternate in-frame splice site in the central coding region, compared to variant 4. The resulting isoform (f) lacks an internal segment, contains a one residue insertion, and has the same N- and C-termini, compared to isoform d.
    Source sequence(s)
    AC011372, AK299167, BC027252, BM664489, U76366
    Consensus CDS
    CCDS47306.1
    UniProtKB/TrEMBL
    A0ACI8TKU3
    Related
    ENSP00000409944.2, ENST00000445265.6
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:239 → 827
    Treacle; Treacher Collins syndrome protein Treacle

  6. NM_001195141.2 → NP_001182070.1  treacle protein isoform g

    See identical proteins and their annotated locations for NP_001182070.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 3' coding region, compared to variant 4. This results in a shorter protein (isoform g), compared to isoform d.
    Source sequence(s)
    AC011372, BC016144, BM664489, U76366
    Consensus CDS
    CCDS43388.1
    UniProtKB/TrEMBL
    A0ACI8TJZ6
    Related
    ENSP00000390717.3, ENST00000427724.7
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:316 → 904
    Treacle; Treacher Collins syndrome protein Treacle

  7. NM_001371623.1 → NP_001358552.1  treacle protein isoform h

    Status: REVIEWED

    Source sequence(s)
    AC011372
    Consensus CDS
    CCDS93805.1
    UniProtKB/TrEMBL
    A0ACI8TL98
    Related
    ENSP00000493815.1, ENST00000643257.2
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:316 → 904
    Treacle; Treacher Collins syndrome protein Treacle

  8. NM_001437406.1 → NP_001424335.1  treacle protein isoform i

    Status: REVIEWED

    Source sequence(s)
    AC011372
    UniProtKB/TrEMBL
    A0A3B3IS06

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    150357697..150400293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268502.5 → XP_005268559.1  treacle protein isoform X1

    UniProtKB/TrEMBL
    A0ACI8TJJ3
    Related
    ENSP00000600629.1, ENST00000930570.1
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:316 → 904
    Treacle; Treacher Collins syndrome protein Treacle

  2. XM_005268504.5 → XP_005268561.1  treacle protein isoform X3

    UniProtKB/TrEMBL
    A0ACI8TJJ3, A0ACI8TKR7
    Related
    ENSP00000600614.1, ENST00000930555.1
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:316 → 904
    Treacle; Treacher Collins syndrome protein Treacle

  3. XM_005268506.5 → XP_005268563.1  treacle protein isoform X5

    UniProtKB/TrEMBL
    A0ACI8TJZ6, E7ETY2
    Related
    ENSP00000427484.1, ENST00000513346.5
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:316 → 904
    Treacle; Treacher Collins syndrome protein Treacle

  4. XM_017009792.3 → XP_016865281.1  treacle protein isoform X7

    UniProtKB/TrEMBL
    A0ACI8TJZ6, A0ACI8TKS3
    Related
    ENSP00000600615.1, ENST00000930556.1

  5. XM_005268503.5 → XP_005268560.1  treacle protein isoform X2

    UniProtKB/TrEMBL
    A0ACI8TJJ3, A0ACI8TLF8
    Related
    ENSP00000600619.1, ENST00000930560.1
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:316 → 904
    Treacle; Treacher Collins syndrome protein Treacle

  6. XM_047417645.1 → XP_047273601.1  treacle protein isoform X4

    UniProtKB/TrEMBL
    A0ACI8TJJ3
    Related
    ENSP00000600613.1, ENST00000930554.1

  7. XM_047417646.1 → XP_047273602.1  treacle protein isoform X6

    UniProtKB/TrEMBL
    A0ACI8TJH2, A0ACI8TJZ6
    Related
    ENSP00000600603.1, ENST00000930544.1

  8. XM_047417647.1 → XP_047273603.1  treacle protein isoform X8

    UniProtKB/TrEMBL
    A0ACI8TJZ6

  9. XM_011537678.4 → XP_011535980.1  treacle protein isoform X9

    UniProtKB/TrEMBL
    A0ACI8TJE3, A0ACI8TJJ3
    Related
    ENSP00000600632.1, ENST00000930573.1
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:388 → 901
    Treacle; Treacher Collins syndrome protein Treacle

  10. XM_047417649.1 → XP_047273605.1  treacle protein isoform X11

    UniProtKB/TrEMBL
    A0ACI8TJA7, A0ACI8TJJ3
    Related
    ENSP00000600607.1, ENST00000930548.1

  11. XM_047417655.1 → XP_047273611.1  treacle protein isoform X19

    UniProtKB/TrEMBL
    A0ACI8TJD6, A0ACI8TL96
    Related
    ENSP00000600631.1, ENST00000930572.1

  12. XM_047417656.1 → XP_047273612.1  treacle protein isoform X20

    UniProtKB/TrEMBL
    A0ACI8TL96

  13. XM_047417648.1 → XP_047273604.1  treacle protein isoform X10

    UniProtKB/TrEMBL
    A0ACI8TJC8, A0ACI8TJJ3
    Related
    ENSP00000600626.1, ENST00000930567.1

  14. XM_047417650.1 → XP_047273606.1  treacle protein isoform X12

    UniProtKB/TrEMBL
    A0ACI8TJJ3

  15. XM_017009793.3 → XP_016865282.1  treacle protein isoform X17

    UniProtKB/TrEMBL
    A0ACI8TJD5, A0ACI8TL96
    Related
    ENSP00000600599.1, ENST00000930540.1

  16. XM_047417654.1 → XP_047273610.1  treacle protein isoform X18

    UniProtKB/TrEMBL
    A0ACI8TL77, A0ACI8TL96
    Related
    ENSP00000600618.1, ENST00000930559.1

  17. XM_017009794.3 → XP_016865283.1  treacle protein isoform X25

    UniProtKB/TrEMBL
    A0ACI8TKS6, A0ACI8TL96
    Related
    ENSP00000600623.1, ENST00000930564.1

  18. XM_047417661.1 → XP_047273617.1  treacle protein isoform X26

    UniProtKB/TrEMBL
    A0ACI8TL96

  19. XM_005268507.5 → XP_005268564.1  treacle protein isoform X13

    UniProtKB/TrEMBL
    A0ACI8TJ99, A0ACI8TKU3
    Related
    ENSP00000600602.1, ENST00000930543.1
    Conserved Domains (2) summary
    smart00667
    Location:6 → 37
    LisH; Lissencephaly type-1-like homology motif
    pfam03546
    Location:239 → 827
    Treacle; Treacher Collins syndrome protein Treacle

  20. XM_047417652.1 → XP_047273608.1  treacle protein isoform X15

    UniProtKB/TrEMBL
    A0ACI8TJA9, A0ACI8TJB9
    Related
    ENSP00000600606.1, ENST00000930547.1

  21. XM_047417659.1 → XP_047273615.1  treacle protein isoform X23

    UniProtKB/TrEMBL
    A0A3B3IS06

  22. XM_047417651.1 → XP_047273607.1  treacle protein isoform X14

    UniProtKB/TrEMBL
    A0ACI8TKU3

  23. XM_047417653.1 → XP_047273609.1  treacle protein isoform X16

    UniProtKB/TrEMBL
    A0ACI8TJA9, A0ACI8TJI6
    Related
    ENSP00000600636.1, ENST00000930577.1

  24. XM_047417658.1 → XP_047273614.1  treacle protein isoform X22

    UniProtKB/TrEMBL
    A0A3B3IS06, A0ACI8TJE5
    Related
    ENSP00000600625.1, ENST00000930566.1

  25. XM_047417660.1 → XP_047273616.1  treacle protein isoform X24

    UniProtKB/TrEMBL
    A0A3B3IS06

  26. XM_047417664.1 → XP_047273620.1  treacle protein isoform X29

    UniProtKB/TrEMBL
    A0A3B3IS06
    Related
    ENSP00000497075.1, ENST00000650162.1

  27. XM_047417665.1 → XP_047273621.1  treacle protein isoform X30

    UniProtKB/TrEMBL
    A0A3B3IS06, A0ACI8TJ91
    Related
    ENSP00000600605.1, ENST00000930546.1

  28. XM_047417662.1 → XP_047273618.1  treacle protein isoform X27

    UniProtKB/TrEMBL
    A0ACI8TKU7

  29. XM_047417663.1 → XP_047273619.1  treacle protein isoform X28

    UniProtKB/TrEMBL
    A0ACI8TJD9, A0ACI8TKU7
    Related
    ENSP00000600627.1, ENST00000930568.1

  30. XM_047417669.1 → XP_047273625.1  treacle protein isoform X34

    UniProtKB/TrEMBL
    A0ACI8TKU7

  31. XM_047417668.1 → XP_047273624.1  treacle protein isoform X33

    UniProtKB/TrEMBL
    A0ACI8TKU7

  32. XM_047417666.1 → XP_047273622.1  treacle protein isoform X31

    UniProtKB/TrEMBL
    A0ACI8TJA4, A0ACI8TKU7
    Related
    ENSP00000600600.1, ENST00000930541.1

  33. XM_047417667.1 → XP_047273623.1  treacle protein isoform X32

    UniProtKB/TrEMBL
    A0ACI8TJB8, A0ACI8TKU7
    Related
    ENSP00000600609.1, ENST00000930550.1

  34. XM_047417670.1 → XP_047273626.1  treacle protein isoform X35

    UniProtKB/TrEMBL
    A0ACI8TKU7

  35. XM_047417671.1 → XP_047273627.1  treacle protein isoform X36

    UniProtKB/TrEMBL
    A0ACI8TKU7

  36. XM_047417672.1 → XP_047273628.1  treacle protein isoform X37

    UniProtKB/TrEMBL
    H0Y8Y7

  37. XM_047417673.1 → XP_047273629.1  treacle protein isoform X38

    UniProtKB/TrEMBL
    H0Y8Y7

  38. XM_047417674.1 → XP_047273630.1  treacle protein isoform X39

    UniProtKB/TrEMBL
    H0Y8Y7

  39. XM_047417675.1 → XP_047273631.1  treacle protein isoform X40

    UniProtKB/TrEMBL
    H0Y8Y7

  40. XM_047417676.1 → XP_047273632.1  treacle protein isoform X41

    UniProtKB/TrEMBL
    H0Y8Y7

  41. XM_017009795.3 → XP_016865284.1  treacle protein isoform X42

    UniProtKB/TrEMBL
    H0Y8Y7

  42. XM_047417677.1 → XP_047273633.1  treacle protein isoform X43

    UniProtKB/TrEMBL
    H0Y8Y7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    150894238..150936834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353340.1 → XP_054209315.1  treacle protein isoform X1

    UniProtKB/TrEMBL
    A0ACI8TJJ3

  2. XM_054353342.1 → XP_054209317.1  treacle protein isoform X3

    UniProtKB/TrEMBL
    A0ACI8TJJ3

  3. XM_054353344.1 → XP_054209319.1  treacle protein isoform X5

    UniProtKB/TrEMBL
    A0ACI8TJZ6

  4. XM_054353346.1 → XP_054209321.1  treacle protein isoform X7

    UniProtKB/TrEMBL
    A0ACI8TJZ6

  5. XM_054353341.1 → XP_054209316.1  treacle protein isoform X2

    UniProtKB/TrEMBL
    A0ACI8TJJ3

  6. XM_054353343.1 → XP_054209318.1  treacle protein isoform X4

    UniProtKB/TrEMBL
    A0ACI8TJJ3

  7. XM_054353345.1 → XP_054209320.1  treacle protein isoform X6

    UniProtKB/TrEMBL
    A0ACI8TJZ6

  8. XM_054353347.1 → XP_054209322.1  treacle protein isoform X8

    UniProtKB/TrEMBL
    A0ACI8TJZ6

  9. XM_054353348.1 → XP_054209323.1  treacle protein isoform X9

    UniProtKB/TrEMBL
    A0ACI8TJJ3

  10. XM_054353350.1 → XP_054209325.1  treacle protein isoform X11

    UniProtKB/TrEMBL
    A0ACI8TJJ3

  11. XM_054353358.1 → XP_054209333.1  treacle protein isoform X19

    UniProtKB/TrEMBL
    A0ACI8TL96

  12. XM_054353359.1 → XP_054209334.1  treacle protein isoform X20

    UniProtKB/TrEMBL
    A0ACI8TL96

  13. XM_054353349.1 → XP_054209324.1  treacle protein isoform X10

    UniProtKB/TrEMBL
    A0ACI8TJJ3

  14. XM_054353351.1 → XP_054209326.1  treacle protein isoform X12

    UniProtKB/TrEMBL
    A0ACI8TJJ3

  15. XM_054353356.1 → XP_054209331.1  treacle protein isoform X17

    UniProtKB/TrEMBL
    A0ACI8TL96

  16. XM_054353357.1 → XP_054209332.1  treacle protein isoform X18

    UniProtKB/TrEMBL
    A0ACI8TL96

  17. XM_054353364.1 → XP_054209339.1  treacle protein isoform X25

    UniProtKB/TrEMBL
    A0ACI8TL96

  18. XM_054353365.1 → XP_054209340.1  treacle protein isoform X26

    UniProtKB/TrEMBL
    A0ACI8TL96

  19. XM_054353352.1 → XP_054209327.1  treacle protein isoform X13

    UniProtKB/TrEMBL
    A0ACI8TKU3

  20. XM_054353354.1 → XP_054209329.1  treacle protein isoform X15

    UniProtKB/TrEMBL
    A0ACI8TJA9

  21. XM_054353362.1 → XP_054209337.1  treacle protein isoform X23

    UniProtKB/TrEMBL
    A0A3B3IS06

  22. XM_054353353.1 → XP_054209328.1  treacle protein isoform X14

    UniProtKB/TrEMBL
    A0ACI8TKU3

  23. XM_054353355.1 → XP_054209330.1  treacle protein isoform X16

    UniProtKB/TrEMBL
    A0ACI8TJA9

  24. XM_054353361.1 → XP_054209336.1  treacle protein isoform X22

    UniProtKB/TrEMBL
    A0A3B3IS06

  25. XM_054353363.1 → XP_054209338.1  treacle protein isoform X24

    UniProtKB/TrEMBL
    A0A3B3IS06

  26. XM_054353368.1 → XP_054209343.1  treacle protein isoform X29

    UniProtKB/TrEMBL
    A0A3B3IS06

  27. XM_054353369.1 → XP_054209344.1  treacle protein isoform X30

    UniProtKB/TrEMBL
    A0A3B3IS06

  28. XM_054353366.1 → XP_054209341.1  treacle protein isoform X27

    UniProtKB/TrEMBL
    A0ACI8TKU7

  29. XM_054353367.1 → XP_054209342.1  treacle protein isoform X28

    UniProtKB/TrEMBL
    A0ACI8TKU7

  30. XM_054353373.1 → XP_054209348.1  treacle protein isoform X34

    UniProtKB/TrEMBL
    A0ACI8TKU7

  31. XM_054353372.1 → XP_054209347.1  treacle protein isoform X33

    UniProtKB/TrEMBL
    A0ACI8TKU7

  32. XM_054353370.1 → XP_054209345.1  treacle protein isoform X31

    UniProtKB/TrEMBL
    A0ACI8TKU7

  33. XM_054353371.1 → XP_054209346.1  treacle protein isoform X32

    UniProtKB/TrEMBL
    A0ACI8TKU7

  34. XM_054353374.1 → XP_054209349.1  treacle protein isoform X35

    UniProtKB/TrEMBL
    A0ACI8TKU7

  35. XM_054353375.1 → XP_054209350.1  treacle protein isoform X36

    UniProtKB/TrEMBL
    A0ACI8TKU7

  36. XM_054353376.1 → XP_054209351.1  treacle protein isoform X37

    UniProtKB/TrEMBL
    H0Y8Y7

  37. XM_054353377.1 → XP_054209352.1  treacle protein isoform X38

    UniProtKB/TrEMBL
    H0Y8Y7

  38. XM_054353378.1 → XP_054209353.1  treacle protein isoform X39

    UniProtKB/TrEMBL
    H0Y8Y7

  39. XM_054353379.1 → XP_054209354.1  treacle protein isoform X40

    UniProtKB/TrEMBL
    H0Y8Y7

  40. XM_054353380.1 → XP_054209355.1  treacle protein isoform X41

    UniProtKB/TrEMBL
    H0Y8Y7

  41. XM_054353381.1 → XP_054209356.1  treacle protein isoform X42

    UniProtKB/TrEMBL
    H0Y8Y7

  42. XM_054353382.1 → XP_054209357.1  treacle protein isoform X43

    UniProtKB/TrEMBL
    H0Y8Y7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001008656.2: Suppressed sequence

    Description
    NM_001008656.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13428.3 GenPept UniProtKB/Swiss-Prot:Q13428

Gene LinkOut

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