|
Name |
Accession |
Description |
Interval |
E-value |
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
387-904 |
7.52e-75 |
|
Treacher Collins syndrome protein Treacle;
:
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 255.77 E-value: 7.52e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEES------DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTG 460
Cdd:pfam03546 1 TPATPGKAGPAATQAKAGKPEEDSESSSEEEsdseeeTPAAKTPLQAKPSGKTPQVRAASAPAKESPRKGAPPVPPGKTG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 461 PAAAQVQVGKQEEDSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
Cdd:pfam03546 81 PAAAQAQAGKPEEDSESSSEESDSDGETPAAAtlttSPAQVKPLGKNSQVRPASTVGKGPSGKGANPAPPGKAGSAAPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 537 QVGKweedSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSE 612
Cdd:pfam03546 161 QVGK----KEEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGaapaPPQKAGPVATQVKAERSKEDSESSE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 613 ESSDSADSEEAPAAMTAAqaKPALKIPQTKACPKKTN--TTASAKVAPVRVGTQAPRKAGTATSPAG-SSPAVAGGTQRP 689
Cdd:pfam03546 237 ESSDSEEEAPAAATPAQA--KPALKTPQTKASPRKGTpiTPTSAKVPPVRVGTPAPWKAGTVTSPACaSSPAVARGAQRP 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 690 aEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769
Cdd:pfam03546 315 -EEDSSSSEESESEEETAPAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEES 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Cdd:pfam03546 394 DSEEAAATPAQVKASGKTPQAKANPAPTKASSAKGAASAPGKVVAAAAQAKQGSPAKVKPPARTPQNSAISVRGQASVPA 473
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 57164979 850 VGKAVATAAQAQTGPEEDSG---SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Cdd:pfam03546 474 VGKAVATAAQAQKGPVGGPQeedSESSEEESDSEEEAPAQAKPSGKTPQVRAASAPAK 531
|
|
| Treacle super family |
cl25490 |
Treacher Collins syndrome protein Treacle; |
212-511 |
2.35e-09 |
|
Treacher Collins syndrome protein Treacle;
The actual alignment was detected with superfamily member pfam03546:
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 60.86 E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 212 VEGKPSVKPAQVKASS--------VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEA 283
Cdd:pfam03546 252 AQAKPALKTPQTKASPrkgtpitpTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVARGAQRPEEDSSSSEESESEEETA 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 284 PAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPaakalLQAK 363
Cdd:pfam03546 332 PAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEESDSEEAAATP-----AQVK 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 364 ASGKTSQVGAASAPAKESPRKGAAPApPGKTGPAVAKAQAGkreedsqssseesdseeeAPAQAKPSGKAPQVRAASApa 443
Cdd:pfam03546 407 ASGKTPQAKANPAPTKASSAKGAASA-PGKVVAAAAQAKQG------------------SPAKVKPPARTPQNSAISV-- 465
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 57164979 444 kespRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMnAAQVKPLGKSPQVKPAST 511
Cdd:pfam03546 466 ----RGQASVPAVGKAVATAAQAQKGPVGGPQEEDSESSEEESDSEEEA-PAQAKPSGKTPQVRAASA 528
|
|
| LisH |
smart00667 |
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ... |
6-37 |
1.85e-03 |
|
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
:
Pssm-ID: 128913 Cd Length: 34 Bit Score: 36.64 E-value: 1.85e-03
10 20 30
....*....|....*....|....*....|..
gi 57164979 6 KRRELLPLIYHHLLRAGYVRAAREVKEQSGQK 37
Cdd:smart00667 2 SRSELNRLILEYLLRNGYEETAETLQKESGLS 33
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
387-904 |
7.52e-75 |
|
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 255.77 E-value: 7.52e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEES------DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTG 460
Cdd:pfam03546 1 TPATPGKAGPAATQAKAGKPEEDSESSSEEEsdseeeTPAAKTPLQAKPSGKTPQVRAASAPAKESPRKGAPPVPPGKTG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 461 PAAAQVQVGKQEEDSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
Cdd:pfam03546 81 PAAAQAQAGKPEEDSESSSEESDSDGETPAAAtlttSPAQVKPLGKNSQVRPASTVGKGPSGKGANPAPPGKAGSAAPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 537 QVGKweedSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSE 612
Cdd:pfam03546 161 QVGK----KEEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGaapaPPQKAGPVATQVKAERSKEDSESSE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 613 ESSDSADSEEAPAAMTAAqaKPALKIPQTKACPKKTN--TTASAKVAPVRVGTQAPRKAGTATSPAG-SSPAVAGGTQRP 689
Cdd:pfam03546 237 ESSDSEEEAPAAATPAQA--KPALKTPQTKASPRKGTpiTPTSAKVPPVRVGTPAPWKAGTVTSPACaSSPAVARGAQRP 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 690 aEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769
Cdd:pfam03546 315 -EEDSSSSEESESEEETAPAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEES 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Cdd:pfam03546 394 DSEEAAATPAQVKASGKTPQAKANPAPTKASSAKGAASAPGKVVAAAAQAKQGSPAKVKPPARTPQNSAISVRGQASVPA 473
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 57164979 850 VGKAVATAAQAQTGPEEDSG---SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Cdd:pfam03546 474 VGKAVATAAQAQKGPVGGPQeedSESSEEESDSEEEAPAQAKPSGKTPQVRAASAPAK 531
|
|
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
212-511 |
2.35e-09 |
|
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 60.86 E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 212 VEGKPSVKPAQVKASS--------VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEA 283
Cdd:pfam03546 252 AQAKPALKTPQTKASPrkgtpitpTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVARGAQRPEEDSSSSEESESEEETA 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 284 PAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPaakalLQAK 363
Cdd:pfam03546 332 PAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEESDSEEAAATP-----AQVK 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 364 ASGKTSQVGAASAPAKESPRKGAAPApPGKTGPAVAKAQAGkreedsqssseesdseeeAPAQAKPSGKAPQVRAASApa 443
Cdd:pfam03546 407 ASGKTPQAKANPAPTKASSAKGAASA-PGKVVAAAAQAKQG------------------SPAKVKPPARTPQNSAISV-- 465
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 57164979 444 kespRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMnAAQVKPLGKSPQVKPAST 511
Cdd:pfam03546 466 ----RGQASVPAVGKAVATAAQAQKGPVGGPQEEDSESSEEESDSEEEA-PAQAKPSGKTPQVRAASA 528
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
157-535 |
3.14e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 157 PRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
Cdd:PHA03247 2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPP 2706
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 237 KAAPAPgkvgdvTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGAT 316
Cdd:PHA03247 2707 TPEPAP------HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKEsprkgaAPAPPGKTGP 396
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------PPPPSLPLGG 2854
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 397 AVAKAQAGKREEDSQSSSEESDSEEEAPAQ---AKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQvgkqeE 473
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ-----P 2929
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 57164979 474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKpastmgMGPLGKGAGPVPPGKVGPATPS 535
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPW------LGALVPGRVAVPRFRVPQPAPS 2985
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
234-676 |
4.95e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.63 E-value: 4.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEkilqvRAASAPAKGTPGK 313
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS-----PSPAANEPDPHPP 2643
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 314 GATPAPPGKAGAvASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 393
Cdd:PHA03247 2644 PTVPPPERPRDD-PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 394 TGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPakesPRKGAAPAPPRKTGPAAAQVQVGKQEE 473
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP----PAAPAAGPPRRLTRPAVASLSESRESL 2798
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPqvkPASTMGMGPLGKGAGPVPP-----GKVGPATPSAQVGKWEEDSESS 548
Cdd:PHA03247 2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQPTAPPPPPGPPPPslplgGSVAPGGDVRRRPPSRSPAAKP 2875
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 549 SEESSDSSDGEVPTAVAPAQEK-SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAM 627
Cdd:PHA03247 2876 AAPARPPVRRLARPAVSRSTESfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 57164979 628 TAAQAKPAL--------KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Cdd:PHA03247 2956 SGAVPQPWLgalvpgrvAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA 3012
|
|
| LisH |
smart00667 |
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ... |
6-37 |
1.85e-03 |
|
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913 Cd Length: 34 Bit Score: 36.64 E-value: 1.85e-03
10 20 30
....*....|....*....|....*....|..
gi 57164979 6 KRRELLPLIYHHLLRAGYVRAAREVKEQSGQK 37
Cdd:smart00667 2 SRSELNRLILEYLLRNGYEETAETLQKESGLS 33
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
387-904 |
7.52e-75 |
|
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 255.77 E-value: 7.52e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 387 APAPPGKTGPAVAKAQAGKREEDSQSSSEES------DSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTG 460
Cdd:pfam03546 1 TPATPGKAGPAATQAKAGKPEEDSESSSEEEsdseeeTPAAKTPLQAKPSGKTPQVRAASAPAKESPRKGAPPVPPGKTG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 461 PAAAQVQVGKQEEDSRSSSEESDSDREALAAM----NAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKVGPATPSA 536
Cdd:pfam03546 81 PAAAQAQAGKPEEDSESSSEESDSDGETPAAAtlttSPAQVKPLGKNSQVRPASTVGKGPSGKGANPAPPGKAGSAAPLV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 537 QVGKweedSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKG----PPQKAGPVAVQVKAEKPMDNSESSE 612
Cdd:pfam03546 161 QVGK----KEEDSESSSEESDSEGEAPPAATQAKPSGKILQVRPASGPAKGaapaPPQKAGPVATQVKAERSKEDSESSE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 613 ESSDSADSEEAPAAMTAAqaKPALKIPQTKACPKKTN--TTASAKVAPVRVGTQAPRKAGTATSPAG-SSPAVAGGTQRP 689
Cdd:pfam03546 237 ESSDSEEEAPAAATPAQA--KPALKTPQTKASPRKGTpiTPTSAKVPPVRVGTPAPWKAGTVTSPACaSSPAVARGAQRP 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 690 aEDSSSSEESDSEEEKTGLAVTVGQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEES 769
Cdd:pfam03546 315 -EEDSSSSEESESEEETAPAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEES 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 770 DSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPS 849
Cdd:pfam03546 394 DSEEAAATPAQVKASGKTPQAKANPAPTKASSAKGAASAPGKVVAAAAQAKQGSPAKVKPPARTPQNSAISVRGQASVPA 473
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 57164979 850 VGKAVATAAQAQTGPEEDSG---SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAK 904
Cdd:pfam03546 474 VGKAVATAAQAQKGPVGGPQeedSESSEEESDSEEEAPAQAKPSGKTPQVRAASAPAK 531
|
|
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
212-511 |
2.35e-09 |
|
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 60.86 E-value: 2.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 212 VEGKPSVKPAQVKASS--------VSTKESPARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEA 283
Cdd:pfam03546 252 AQAKPALKTPQTKASPrkgtpitpTSAKVPPVRVGTPAPWKAGTVTSPACASSPAVARGAQRPEEDSSSSEESESEEETA 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 284 PAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPaakalLQAK 363
Cdd:pfam03546 332 PAAAVGQAKSVGKGLQGKAASAPTKGPSGQGTAPVPPGKTGPAVAQVKAEAQEDSESSEEESDSEEAAATP-----AQVK 406
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 364 ASGKTSQVGAASAPAKESPRKGAAPApPGKTGPAVAKAQAGkreedsqssseesdseeeAPAQAKPSGKAPQVRAASApa 443
Cdd:pfam03546 407 ASGKTPQAKANPAPTKASSAKGAASA-PGKVVAAAAQAKQG------------------SPAKVKPPARTPQNSAISV-- 465
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 57164979 444 kespRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMnAAQVKPLGKSPQVKPAST 511
Cdd:pfam03546 466 ----RGQASVPAVGKAVATAAQAQKGPVGGPQEEDSESSEEESDSEEEA-PAQAKPSGKTPQVRAASA 528
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
157-535 |
3.14e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.40 E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 157 PRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPAR 236
Cdd:PHA03247 2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPP 2706
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 237 KAAPAPgkvgdvTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGAT 316
Cdd:PHA03247 2707 TPEPAP------HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 317 PAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKEsprkgaAPAPPGKTGP 396
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG------PPPPSLPLGG 2854
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 397 AVAKAQAGKREEDSQSSSEESDSEEEAPAQ---AKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPAAAQVQvgkqeE 473
Cdd:PHA03247 2855 SVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlaRPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ-----P 2929
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 57164979 474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPQVKpastmgMGPLGKGAGPVPPGKVGPATPS 535
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPW------LGALVPGRVAVPRFRVPQPAPS 2985
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
234-676 |
4.95e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 47.63 E-value: 4.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 234 PARKAAPAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEkilqvRAASAPAKGTPGK 313
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS-----PSPAANEPDPHPP 2643
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 314 GATPAPPGKAGAvASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 393
Cdd:PHA03247 2644 PTVPPPERPRDD-PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLP 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 394 TGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPakesPRKGAAPAPPRKTGPAAAQVQVGKQEE 473
Cdd:PHA03247 2723 PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP----PAAPAAGPPRRLTRPAVASLSESRESL 2798
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 474 DSRSSSEESDSDREALAAMNAAQVKPLGKSPqvkPASTMGMGPLGKGAGPVPP-----GKVGPATPSAQVGKWEEDSESS 548
Cdd:PHA03247 2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLP---PPTSAQPTAPPPPPGPPPPslplgGSVAPGGDVRRRPPSRSPAAKP 2875
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 549 SEESSDSSDGEVPTAVAPAQEK-SLGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAM 627
Cdd:PHA03247 2876 AAPARPPVRRLARPAVSRSTESfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 57164979 628 TAAQAKPAL--------KIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPA 676
Cdd:PHA03247 2956 SGAVPQPWLgalvpgrvAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA 3012
|
|
| Treacle |
pfam03546 |
Treacher Collins syndrome protein Treacle; |
883-926 |
9.43e-05 |
|
Treacher Collins syndrome protein Treacle;
Pssm-ID: 460967 [Multi-domain] Cd Length: 531 Bit Score: 46.22 E-value: 9.43e-05
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 57164979 883 TLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQA 926
Cdd:pfam03546 43 TPLQAKPSGKTPQVRAASAPAKESPRKGAPPVPPGKTGPAAAQA 86
|
|
| kgd |
PRK12270 |
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
385-467 |
6.76e-04 |
|
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 43.73 E-value: 6.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 385 GAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKT----- 459
Cdd:PRK12270 37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAavede 116
|
90
....*....|...
gi 57164979 460 -----GPAAAQVQ 467
Cdd:PRK12270 117 vtplrGAAAAVAK 129
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
234-499 |
8.79e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 43.30 E-value: 8.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 234 PARKAAPAPGkvGDVTPQVKGGALPPAKRAkkpeeesesseEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGK 313
Cdd:PRK07003 360 PAVTGGGAPG--GGVPARVAGAVPAPGARA-----------AAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAP 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 314 GATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGK 393
Cdd:PRK07003 427 PAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAA 506
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 394 TGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAA---------------SAPAKESPRKGAAPAPPRK 458
Cdd:PRK07003 507 VPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAAldvlrnagmrvssdrGARAAAAAKPAAAPAAAPK 586
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 57164979 459 TGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKP 499
Cdd:PRK07003 587 PAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPP 627
|
|
| LisH |
smart00667 |
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ... |
6-37 |
1.85e-03 |
|
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.
Pssm-ID: 128913 Cd Length: 34 Bit Score: 36.64 E-value: 1.85e-03
10 20 30
....*....|....*....|....*....|..
gi 57164979 6 KRRELLPLIYHHLLRAGYVRAAREVKEQSGQK 37
Cdd:smart00667 2 SRSELNRLILEYLLRNGYEETAETLQKESGLS 33
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
240-675 |
3.10e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.85 E-value: 3.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 240 PAPGKVGDVTPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEkilQVRAASAPAKGTPGKGATPAP 319
Cdd:PHA03247 2551 PPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRG---DPRGPAPPSPLPPDTHAPDPP 2627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 320 PGKAGAVASQTKAGKPEEDSESSSEESSdseeetPAAKALLQAKASGKTSQVGAASAPAkESPRKGAAPAPPGKTGPAVA 399
Cdd:PHA03247 2628 PPSPSPAANEPDPHPPPTVPPPERPRDD------PAPGRVSRPRRARRLGRAAQASSPP-QRPRRRAARPTVGSLTSLAD 2700
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 400 KAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPA-PPRKTGPAAAQVQVGKQEEDSRSS 478
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPArPARPPTTAGPPAPAPPAAPAAGPP 2780
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 479 SEESDSDREALAAMNAAQVKPLGKSPQVKPAStmgmgplgkGAGPVPPGKVGPATPSAqvgkweeDSESSSEESSDSSDG 558
Cdd:PHA03247 2781 RRLTRPAVASLSESRESLPSPWDPADPPAAVL---------APAAALPPAASPAGPLP-------PPTSAQPTAPPPPPG 2844
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 559 EVPTAVAPAQEKSLGNILQAKPTS-SPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALK 637
Cdd:PHA03247 2845 PPPPSLPLGGSVAPGGDVRRRPPSrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP 2924
|
410 420 430
....*....|....*....|....*....|....*...
gi 57164979 638 IPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSP 675
Cdd:PHA03247 2925 PPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQP 2962
|
|
| kgd |
PRK12270 |
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
378-465 |
4.75e-03 |
|
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 41.03 E-value: 4.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 378 AKESPRKGAAPAPPGKTGPAVAKAQAgkreedsqssseesdSEEEAPAQAKPSGKAPQVRAASAPAKESPRKGAAPAPPR 457
Cdd:PRK12270 34 ADYGPGSTAAPTAAAAAAAAAASAPA---------------AAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAA 98
|
....*...
gi 57164979 458 KTGPAAAQ 465
Cdd:PRK12270 99 PPAAAAAA 106
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
214-463 |
5.11e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 40.60 E-value: 5.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 214 GKPSVKPAQVKASSVSTKESPARKAAPAPGkvgdvtPQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKA 293
Cdd:PRK07003 371 GVPARVAGAVPAPGARAAAAVGASAVPAVT------AVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAAD 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 294 SEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGA 373
Cdd:PRK07003 445 GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAA 524
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 374 ASAPAKES-PRKGAAPAPPGKTGPAVAK----AQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRA------ASAP 442
Cdd:PRK07003 525 AAPPAPEArPPTPAAAAPAARAGGAAAAldvlRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVqvptprARAA 604
|
250 260
....*....|....*....|.
gi 57164979 443 AKESPRKGAAPAPPRKTGPAA 463
Cdd:PRK07003 605 TGDAPPNGAARAEQAAESRGA 625
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
177-465 |
8.96e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 39.97 E-value: 8.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 177 GSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGKVGDVTPQVKGGA 256
Cdd:PRK07764 391 AGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAP 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 257 LPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQ-------------------VKASEKILQVRAASAPAKG-------- 309
Cdd:PRK07764 471 AAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAgaddaatlrerwpeilaavPKRSRKTWAILLPEATVLGvrgdtlvl 550
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 310 ---TPGKGATPAPPGKAG-----------------AVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTS 369
Cdd:PRK07764 551 gfsTGGLARRFASPGNAEvlvtalaeelggdwqveAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPA 630
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 57164979 370 QVGAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAPAKESPRK 449
Cdd:PRK07764 631 GAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPP 710
|
330
....*....|....*.
gi 57164979 450 GAAPAPPRKTGPAAAQ 465
Cdd:PRK07764 711 AGQADDPAAQPPQAAQ 726
|
|
| |
