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TAPBP TAP binding protein [ Homo sapiens (human) ]

Gene ID: 6892, updated on 1-Jun-2020

Summary

Official Symbol
TAPBPprovided by HGNC
Official Full Name
TAP binding proteinprovided by HGNC
Primary source
HGNC:HGNC:11566
See related
Ensembl:ENSG00000231925 MIM:601962
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPN; TAPA; TPSN; NGS17
Summary
This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 38.1), appendix (RPKM 25.3) and 25 other tissues See more
Orthologs

Genomic context

See TAPBP in Genome Data Viewer
Location:
6p21.32
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (33299694..33314387, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33267471..33282164, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene microRNA 6834 Neighboring gene prefoldin subunit 6 Neighboring gene ral guanine nucleotide dissociation stimulator like 2 Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene death domain associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with TAPBP; predicted interaction to be involved in antigenicity/immunity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MHC class I protein binding TAS
Traceable Author Statement
more info
PubMed 
TAP complex binding IDA
Inferred from Direct Assay
more info
PubMed 
TAP1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
TAP1 binding TAS
Traceable Author Statement
more info
PubMed 
TAP2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
TAP2 binding TAS
Traceable Author Statement
more info
PubMed 
peptide antigen binding TAS
Traceable Author Statement
more info
PubMed 
peptide antigen-transporting ATPase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tapasin
Names
NGS-17
TAP binding protein (tapasin)
TAP-associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009876.1 RefSeqGene

    Range
    4826..19519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_114

mRNA and Protein(s)

  1. NM_003190.5NP_003181.3  tapasin isoform 1 precursor

    See identical proteins and their annotated locations for NP_003181.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AB010639, AF029750, AL662820
    Consensus CDS
    CCDS34426.1
    UniProtKB/Swiss-Prot
    O15533
    UniProtKB/TrEMBL
    A0A024RCT1
    Related
    ENSP00000395701.2, ENST00000434618.6
    Conserved Domains (1) summary
    cl11960
    Location:260391
    Ig; Immunoglobulin domain
  2. NM_172208.2NP_757345.2  tapasin isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AL662820, AU117273, AW028178, BC080574, BI523615
    Consensus CDS
    CCDS34428.2
    UniProtKB/Swiss-Prot
    O15533
    UniProtKB/TrEMBL
    A0A0A0MSV9
    Related
    ENSP00000404833.2, ENST00000426633.6
    Conserved Domains (1) summary
    cl11960
    Location:255391
    Ig; Immunoglobulin domain
  3. NM_172209.3NP_757346.2  tapasin isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AF029750, AL662820, AU117273, EU693375
    Consensus CDS
    CCDS34427.2
    UniProtKB/Swiss-Prot
    O15533
    UniProtKB/TrEMBL
    A0A0A0MT98
    Related
    ENSP00000419659.1, ENST00000489157.5
    Conserved Domains (1) summary
    cl11960
    Location:168304
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    33299694..33314387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011227.1XP_016866716.1  tapasin isoform X1

  2. XM_011514828.3XP_011513130.1  tapasin isoform X2

    See identical proteins and their annotated locations for XP_011513130.1

    Conserved Domains (1) summary
    cl11960
    Location:255391
    Ig; Immunoglobulin domain

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    4711179..4725870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    4543212..4557902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    4735630..4750321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    4494115..4508814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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