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Tapbp TAP binding protein [ Mus musculus (house mouse) ]

Gene ID: 21356, updated on 8-Dec-2022

Summary

Official Symbol
Tapbpprovided by MGI
Official Full Name
TAP binding proteinprovided by MGI
Primary source
MGI:MGI:1201689
See related
Ensembl:ENSMUSG00000024308 AllianceGenome:MGI:1201689
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TPN; D17Wsu91e
Summary
Predicted to enable TAP complex binding activity; TAP1 binding activity; and TAP2 binding activity. Involved in peptide antigen stabilization. Acts upstream of or within antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent and defense response. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of MHC class I peptide loading complex. Is expressed in several structures, including genitourinary system; hemolymphoid system; nervous system; notochord; and retina. Human ortholog(s) of this gene implicated in MHC class I deficiency and severe combined immunodeficiency. Orthologous to human TAPBP (TAP binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in duodenum adult (RPKM 118.6), mammary gland adult (RPKM 101.7) and 23 other tissues See more
Orthologs
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Genomic context

See Tapbp in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34138452..34148264)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33919478..33929290)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene Fas death domain-associated protein Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene predicted gene, 19412 Neighboring gene ral guanine nucleotide dissociation stimulator-like 2 Neighboring gene prefoldin subunit 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables TAP complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables TAP complex binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP1 binding ISO
Inferred from Sequence Orthology
more info
 
enables TAP2 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class I peptide loading complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of MHC class I peptide loading complex ISO
Inferred from Sequence Orthology
more info
 
part_of Tapasin-ERp57 complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
tapasin
Names
TAP-associated protein
TPSN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025313.1NP_001020484.1  tapasin isoform 1 precursor

    See identical proteins and their annotated locations for NP_001020484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK014566, AK054174, CAAA01015907, CF168841
    Consensus CDS
    CCDS37572.1
    UniProtKB/TrEMBL
    Q3TCU5, Q8C6N4, Q9D679
    Related
    ENSMUSP00000025161.8, ENSMUST00000025161.10
    Conserved Domains (1) summary
    cl11960
    Location:258394
    Ig; Immunoglobulin domain
  2. NM_009318.2NP_033344.1  tapasin isoform 2 precursor

    See identical proteins and their annotated locations for NP_033344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal aa, compared to isoform 1.
    Source sequence(s)
    AK014566, AK054174, CAAA01015907, CF168841
    Consensus CDS
    CCDS89072.1
    UniProtKB/Swiss-Prot
    Q9R233, Q9Z1W3
    UniProtKB/TrEMBL
    Q3U9A3, Q8C6N4, Q9D679
    Related
    ENSMUSP00000157315.2, ENSMUST00000234247.2
    Conserved Domains (1) summary
    cl11960
    Location:258394
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34138452..34148264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)