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SYK spleen associated tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 6850, updated on 14-Jun-2020

Summary

Official Symbol
SYKprovided by HGNC
Official Full Name
spleen associated tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:11491
See related
Ensembl:ENSG00000165025 MIM:600085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p72-Syk
Summary
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Expression
Broad expression in lymph node (RPKM 32.4), appendix (RPKM 24.8) and 20 other tissues See more
Orthologs

Genomic context

See SYK in Genome Data Viewer
Location:
9q22.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (90801600..90898549)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (93564012..93660842)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 7 subfamily E member 109 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 108 pseudogene Neighboring gene uncharacterized LOC105379829 Neighboring gene uncharacterized LOC105376143 Neighboring gene uncharacterized LOC100507103 Neighboring gene uncharacterized LOC105376144

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
NHGRI GWA Catalog
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.
NHGRI GWA Catalog
Association of intronic sequence variant in the gene encoding spleen tyrosine kinase with susceptibility to vascular dementia.
NHGRI GWA Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef In promonocytic cells, Nef/Hck recruits the ZAP-70 homolog Syk to downregulate MHC-I PubMed
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with SYK PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25043, FLJ37489, DKFZp313N1010

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
SH2 domain binding IEA
Inferred from Electronic Annotation
more info
 
Toll-like receptor binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
interleukin-15 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
phosphatase binding IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine residue binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphotyrosine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
activation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adaptive immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
beta selection IEA
Inferred from Electronic Annotation
more info
 
blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to low-density lipoprotein particle stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to molecule of fungal origin ISS
Inferred from Sequence or Structural Similarity
more info
 
collagen-activated tyrosine kinase receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
defense response to bacterium ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
integrin-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
interleukin-2-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-3-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte activation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
leukocyte cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
leukotriene biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lymph vessel development ISS
Inferred from Sequence or Structural Similarity
more info
 
macrophage activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
macrophage activation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil activation involved in immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet activation TAS
Traceable Author Statement
more info
 
positive regulation of B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of alpha-beta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of alpha-beta T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytokine secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gamma-delta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-10 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-12 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-3 biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-4 production ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of interleukin-6 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-8 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of killing of cells of other organism IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mast cell degranulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of monocyte chemotactic protein-1 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of receptor internalization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of tumor necrosis factor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type I interferon production IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of arachidonic acid secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neutrophil degranulation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of platelet activation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of platelet aggregation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of superoxide anion generation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of tumor necrosis factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
serotonin secretion by platelet ISS
Inferred from Sequence or Structural Similarity
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
B cell receptor complex IEA
Inferred from Electronic Annotation
more info
 
T cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IC
Inferred by Curator
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
early phagosome ISS
Inferred from Sequence or Structural Similarity
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase SYK
Names
spleen tyrosine kinase
NP_001128524.1
NP_001167638.1
NP_001167639.1
NP_003168.2
XP_005252204.1
XP_011517248.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017046.2 RefSeqGene

    Range
    5090..101820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001135052.4NP_001128524.1  tyrosine-protein kinase SYK isoform Syk(S)

    See identical proteins and their annotated locations for NP_001128524.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (Syk(S)) that is shorter than isoform Syk(L). Both variants 2 and 4 encode isoform Syk(S).
    Source sequence(s)
    AL354862, W33104, Z29630
    Consensus CDS
    CCDS47992.1
    UniProtKB/Swiss-Prot
    P43405
    UniProtKB/TrEMBL
    A0A024R273
    Related
    ENSP00000364904.4, ENST00000375751.8
    Conserved Domains (4) summary
    cd05116
    Location:352608
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:13116
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:164262
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
    pfam07714
    Location:351603
    Pkinase_Tyr; Protein tyrosine kinase
  2. NM_001174167.3NP_001167638.1  tyrosine-protein kinase SYK isoform Syk(L)

    See identical proteins and their annotated locations for NP_001167638.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode isoform Syk(L).
    Source sequence(s)
    AL354862, BU429809, W33104, X73568
    Consensus CDS
    CCDS6688.1
    UniProtKB/Swiss-Prot
    P43405
    UniProtKB/TrEMBL
    A0A024R244
    Related
    ENSP00000364898.1, ENST00000375746.1
    Conserved Domains (3) summary
    cd05116
    Location:375631
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:13116
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:164262
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
  3. NM_001174168.3NP_001167639.1  tyrosine-protein kinase SYK isoform Syk(S)

    See identical proteins and their annotated locations for NP_001167639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (Syk(S)) that is shorter than isoform Syk(L). Both variants 2 and 4 encode isoform Syk(S).
    Source sequence(s)
    AL354862, BC011399, BM019270, W33104
    Consensus CDS
    CCDS47992.1
    UniProtKB/Swiss-Prot
    P43405
    UniProtKB/TrEMBL
    A0A024R273
    Related
    ENSP00000364899.1, ENST00000375747.5
    Conserved Domains (4) summary
    cd05116
    Location:352608
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:13116
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:164262
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
    pfam07714
    Location:351603
    Pkinase_Tyr; Protein tyrosine kinase
  4. NM_003177.7NP_003168.2  tyrosine-protein kinase SYK isoform Syk(L)

    See identical proteins and their annotated locations for NP_003168.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (Syk(L)). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AL354862, BC001645, L28824, W33104
    Consensus CDS
    CCDS6688.1
    UniProtKB/Swiss-Prot
    P43405
    UniProtKB/TrEMBL
    A0A024R244
    Related
    ENSP00000364907.4, ENST00000375754.9
    Conserved Domains (3) summary
    cd05116
    Location:375631
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:13116
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:164262
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    90801600..90898549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252147.4XP_005252204.1  tyrosine-protein kinase SYK isoform X1

    See identical proteins and their annotated locations for XP_005252204.1

    UniProtKB/Swiss-Prot
    P43405
    UniProtKB/TrEMBL
    A0A024R244
    Conserved Domains (3) summary
    cd05116
    Location:375631
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:13116
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:164262
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
  2. XM_011518946.3XP_011517248.1  tyrosine-protein kinase SYK isoform X1

    See identical proteins and their annotated locations for XP_011517248.1

    UniProtKB/Swiss-Prot
    P43405
    UniProtKB/TrEMBL
    A0A024R244
    Conserved Domains (3) summary
    cd05116
    Location:375631
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:13116
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:164262
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

RNA

  1. XR_001746370.2 RNA Sequence

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