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Syk spleen tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 20963, updated on 22-Nov-2020

Summary

Official Symbol
Sykprovided by MGI
Official Full Name
spleen tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:99515
See related
Ensembl:ENSMUSG00000021457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sykb
Expression
Biased expression in spleen adult (RPKM 36.0), mammary gland adult (RPKM 7.6) and 11 other tissues See more
Orthologs

Genomic context

See Syk in Genome Data Viewer
Location:
13 A5; 13 27.41 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (52736670..52802828)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (52582610..52648792)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (52692251..52744161)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33168 Neighboring gene predicted gene 2848 Neighboring gene expressed sequence BB123696 Neighboring gene predicted gene, 33315 Neighboring gene AU RNA binding protein/enoyl-coenzyme A hydratase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (15)  1 citation
  • Chemically induced (ENU) (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
SH2 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
Toll-like receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
integrin binding ISO
Inferred from Sequence Orthology
more info
 
interleukin-15 receptor binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
activation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
beta selection IGI
Inferred from Genetic Interaction
more info
PubMed 
blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to molecule of fungal origin IMP
Inferred from Mutant Phenotype
more info
PubMed 
collagen-activated tyrosine kinase receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
enzyme linked receptor protein signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
integrin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-3-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
leukotriene biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymph vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
macrophage activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil activation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil activation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of alpha-beta T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of alpha-beta T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of alpha-beta T cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gamma-delta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of granulocyte macrophage colony-stimulating factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-3 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of killing of cells of other organism ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mast cell degranulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mast cell degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
positive regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein import into nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of arachidonic acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of immune response ISO
Inferred from Sequence Orthology
more info
 
regulation of neutrophil degranulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
serotonin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
serotonin secretion by platelet IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
B cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
T cell receptor complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
early phagosome IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase SYK
NP_001185906.1
NP_035648.2
XP_006516958.1
XP_006516960.1
XP_017170960.1
XP_036013851.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198977.1NP_001185906.1  tyrosine-protein kinase SYK

    See identical proteins and their annotated locations for NP_001185906.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK049207, BC065121
    Consensus CDS
    CCDS26517.1
    UniProtKB/Swiss-Prot
    P48025
    UniProtKB/TrEMBL
    Q3UPF7, Q6P1E0
    Related
    ENSMUSP00000113852.1, ENSMUST00000120135.7
    Conserved Domains (3) summary
    cd05116
    Location:370625
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
  2. NM_011518.2NP_035648.2  tyrosine-protein kinase SYK

    See identical proteins and their annotated locations for NP_035648.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BB629720, BC065121, U36776
    Consensus CDS
    CCDS26517.1
    UniProtKB/Swiss-Prot
    P48025
    UniProtKB/TrEMBL
    Q3UPF7, Q6P1E0
    Related
    ENSMUSP00000060828.6, ENSMUST00000055087.6
    Conserved Domains (3) summary
    cd05116
    Location:370625
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    52736670..52802828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516897.5XP_006516960.1  tyrosine-protein kinase SYK isoform X2

    See identical proteins and their annotated locations for XP_006516960.1

    Related
    ENSMUSP00000112914.1
    Conserved Domains (4) summary
    cd05116
    Location:347602
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
    pfam07714
    Location:345597
    Pkinase_Tyr; Protein tyrosine kinase
  2. XM_006516895.5XP_006516958.1  tyrosine-protein kinase SYK isoform X1

    See identical proteins and their annotated locations for XP_006516958.1

    UniProtKB/Swiss-Prot
    P48025
    UniProtKB/TrEMBL
    Q3UPF7
    Conserved Domains (3) summary
    cd05116
    Location:370625
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:12115
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cd10401
    Location:163261
    SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
  3. XM_036157958.1XP_036013851.1  tyrosine-protein kinase SYK isoform X2

  4. XM_017315471.3XP_017170960.1  tyrosine-protein kinase SYK isoform X3

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