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STAT3 signal transducer and activator of transcription 3 [ Homo sapiens (human) ]

Gene ID: 6774, updated on 1-Jun-2020

Summary

Official Symbol
STAT3provided by HGNC
Official Full Name
signal transducer and activator of transcription 3provided by HGNC
Primary source
HGNC:HGNC:11364
See related
Ensembl:ENSG00000168610 MIM:102582
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APRF; HIES; ADMIO; ADMIO1
Summary
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in gall bladder (RPKM 47.5), lung (RPKM 47.3) and 25 other tissues See more
Orthologs

Genomic context

See STAT3 in Genome Data Viewer
Location:
17q21.2
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (42313324..42388502, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40465342..40540586, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5B Neighboring gene signal transducer and activator of transcription 5A Neighboring gene uncharacterized LOC102725238 Neighboring gene caveolae associated protein 1 Neighboring gene RNA, U7 small nuclear 97 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.
NHGRI GWA Catalog
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
NHGRI GWA Catalog
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) activates STAT3 leading to regulation of miRNA expression levels (MIR21, MIR181B1, MIR155) PubMed
env HIV-1 gp120-induced release of IL-6 activates STAT3 in primary human monocyte-derived dendritic cells PubMed
env HIV-1 gp120 recruits SOCS-3 through IL-10 activation for suppressing IL-6 and IL-6 dependent STAT3 in immature dentritic cells PubMed
env HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells PubMed
env The transcription factors and kinases c-Jun, JNK, MEK, p38 MAPK, STAT-3, JAK-1, TFII D, TFII F, eIF-4E, and RNA polymerase II are induced by HIV-1 gp120 PubMed
Nef nef HIV-1 gp120-induced release of IL-10 inhibits STAT3 activation, leading to suppress HIV-1 Nef-induced IL-6 secretion in immature dentritic cells PubMed
nef Both myristoylation and acidic cluster of Nef are essential to induce the tyrosine phosphorylation of STAT3 PubMed
nef HIV-1 Nef induces phosphorylation of STAT3 in M2-type macrophages PubMed
nef HIV-1 Nef increases expression of both VEGF and its transcriptional regulator, hypoxia-inducible factor 2alpha (HIF-2alpha), in a Src kinase-and Stat3-dependent manner PubMed
nef HIV-1 Nef activates signal transducer and activator of transcription 3 (STAT3) in the granulocyte-macrophage colony-stimulating factor-independent myeloid cell line, TF-1, and in primary human macrophages PubMed
nef HIV-1 Nef specifically activates STAT3 in primary human monocyte-derived macrophages (MDM); Nef-dependent STAT3 activation is mediated by the release of soluble factor(s), including MIP-1alpha and IL-6 PubMed
nef HIV-1 Nef activates expression of phospho-Stat3, one of the downstream signaling pathways for cell proliferation PubMed
nef HIV-1 Nef, through its PxxP and RR106 motifs, upregulates Src kinase activity and signal transducer and activator of transcription 3 (Stat3) phosphorylation, and activates the Ras-c-Raf-MAPK1,2 pathway in podocytes PubMed
nef The expression of HIV-1 Nef in immature dendritic cells activates STAT3 PubMed
Tat tat HIV-1 Tat-induced upregulation and phosphorylation of STAT3 expression results in GFAP, Egr-1 and p300 transcription and protein expression in both Tat-expressing astrocytes and HIV-infected astrocytes PubMed
tat Expression of HIV-1 Tat upregulates the abundance of signal transducer and activator of transcription 3 (STAT3) in the nucleoli of Jurkat T-cells PubMed
tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
tat IL10 and STAT3 are required for HIV-1 Tat-mediated inhibition of autophagy in bystander macrophages/monocytic cells PubMed
tat Ectopic expression of HIV-1 Tat induces the production of human IL-6 (huIL-6) and its receptor (huIL-6Ra) and activates STAT3 signaling; these effects are involved in Tat-mediated activation of Kaposi's sarcoma-associated herpes virus (KSHV) replication PubMed
matrix gag HIV-1 MA recruits STAT3 to the LXR promoter region containing the STAT responsive sequence TTCAGGGAA; STAT3 mediates upregulation of NR1H3 (LXR-alpha) gene expression PubMed
gag HIV-1 MA increases phosphorylation of STAT3 PubMed
gag HIV-1 MA natural variant S75X upregulates the expression of STAT1 and STAT3, and induces phosphorylation of STAT1 at position S727 and STAT3 at position Y705 in Epstein-Barr virus (EBV)-infected B-lymphocytes PubMed
gag HIV-1 MA natural variant S75X-mediated proliferation of both Epstein-Barr virus (EBV)-infected primary and fully transformed B-lymphocytes requires AKT, ERK1/2, and STAT3 pathways PubMed
gag Treatment of human stellate cells with HIV-1 MA induces phosphorylation of STAT1 and STAT3 proteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20882, MGC16063

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CCR5 chemokine receptor binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II repressing transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
glucocorticoid receptor binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
JAK-STAT cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
JAK-STAT cascade TAS
Traceable Author Statement
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
JAK-STAT cascade involved in growth hormone signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
T-helper 17 cell lineage commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
astrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cellular response to cytokine stimulus TAS
Traceable Author Statement
more info
 
cellular response to hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to leptin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eating behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
eye photoreceptor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
growth hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-15-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-21-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-23-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-27-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-35-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-6-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-6-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-7-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-9-mediated signaling pathway TAS
Traceable Author Statement
more info
 
intracellular receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
leptin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leptin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
mRNA transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
miRNA mediated inhibition of translation IDA
Inferred from Direct Assay
more info
PubMed 
modulation of chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
negative regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of glycolytic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hydrogen peroxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron migration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene silencing by miRNA IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-6 biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of metalloendopeptidase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of tyrosine phosphorylation of STAT protein TAS
Traceable Author Statement
more info
 
positive regulation of vascular endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
postsynapse to nucleus signaling pathway IEA
Inferred from Electronic Annotation
more info
 
protein import into nucleus IDA
Inferred from Direct Assay
more info
PubMed 
radial glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of feeding behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mitochondrial membrane permeability IEA
Inferred from Electronic Annotation
more info
 
regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
response to estradiol IDA
Inferred from Direct Assay
more info
PubMed 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to leptin IDA
Inferred from Direct Assay
more info
PubMed 
response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sexual reproduction ISS
Inferred from Sequence or Structural Similarity
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
somatic stem cell population maintenance TAS
Traceable Author Statement
more info
 
temperature homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA polymerase II transcription factor complex IC
Inferred by Curator
more info
PubMed 
RNA polymerase II transcription factor complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
signal transducer and activator of transcription 3
Names
DNA-binding protein APRF
acute-phase response factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007370.1 RefSeqGene

    Range
    5001..80171
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_112

mRNA and Protein(s)

  1. NM_001369512.1NP_001356441.1  signal transducer and activator of transcription 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC087691, L29277
    Related
    ENSP00000467985.1, ENST00000588969.5
    Conserved Domains (4) summary
    cd10374
    Location:554715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  2. NM_001369513.1NP_001356442.1  signal transducer and activator of transcription 3 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC087691, AC107993
    Conserved Domains (4) summary
    cd10374
    Location:554715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  3. NM_001369514.1NP_001356443.1  signal transducer and activator of transcription 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC087691, AC107993
    Conserved Domains (4) summary
    cd10374
    Location:554714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  4. NM_001369516.1NP_001356445.1  signal transducer and activator of transcription 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC087691, AC107993
    Conserved Domains (4) summary
    cd10374
    Location:554714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  5. NM_001369517.1NP_001356446.1  signal transducer and activator of transcription 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC087691, AC107993
    Conserved Domains (4) summary
    cd10374
    Location:554715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  6. NM_001369518.1NP_001356447.1  signal transducer and activator of transcription 3 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC087691, AC107993
    Related
    ENSP00000467000.1, ENST00000585517.5
    Conserved Domains (4) summary
    cd10374
    Location:554715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  7. NM_001369519.1NP_001356448.1  signal transducer and activator of transcription 3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC087691, AC107993
    Conserved Domains (4) summary
    cd10374
    Location:554714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  8. NM_001369520.1NP_001356449.1  signal transducer and activator of transcription 3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC087691, AC107993
    Conserved Domains (4) summary
    cd10374
    Location:554714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  9. NM_003150.4NP_003141.2  signal transducer and activator of transcription 3 isoform 2

    See identical proteins and their annotated locations for NP_003141.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC087691, AI631896, AK092965, BC000627, BC008044, BI461226, CB216860, CF454565
    Consensus CDS
    CCDS32657.1
    UniProtKB/Swiss-Prot
    P40763
    Related
    ENSP00000384943.3, ENST00000404395.3
    Conserved Domains (4) summary
    cd10374
    Location:554714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  10. NM_139276.3NP_644805.1  signal transducer and activator of transcription 3 isoform 1

    See identical proteins and their annotated locations for NP_644805.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1).
    Source sequence(s)
    AC087691, AI631896, AK092965, BC008044, BC014482, BI461226, CB216860, CF454565
    Consensus CDS
    CCDS32656.1
    UniProtKB/Swiss-Prot
    P40763
    Related
    ENSP00000264657.4, ENST00000264657.9
    Conserved Domains (4) summary
    cd10374
    Location:554715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  11. NM_213662.2NP_998827.1  signal transducer and activator of transcription 3 isoform 3

    See identical proteins and their annotated locations for NP_998827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also called STAT3B or STAT3beta, uses an alternate splice site in the 3' coding region, resulting in an early stop codon, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC087691, AC107993, AI631896, AK092965, BC008044, BC014482, CB216860, CB321646, CF454565
    Consensus CDS
    CCDS59288.1
    UniProtKB/Swiss-Prot
    P40763
    Conserved Domains (4) summary
    cd10374
    Location:554715
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    42313324..42388502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024973.2XP_016880462.1  signal transducer and activator of transcription 3 isoform X4

    Conserved Domains (4) summary
    cd10374
    Location:554714
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    cd16853
    Location:139318
    STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)
    cd16847
    Location:321484
    STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
  2. XM_024450896.1XP_024306664.1  signal transducer and activator of transcription 3 isoform X5

    Related
    ENSP00000373923.3, ENST00000389272.7
    Conserved Domains (4) summary
    cd10374
    Location:586747
    SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins
    smart00964
    Location:2120
    STAT_int; STAT protein, protein interaction domain
    pfam01017
    Location:141319
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:321605
    STAT_bind; STAT protein, DNA binding domain
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