U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MRPL44 mitochondrial ribosomal protein L44 [ Homo sapiens (human) ]

Gene ID: 65080, updated on 25-Jan-2024

Summary

Official Symbol
MRPL44provided by HGNC
Official Full Name
mitochondrial ribosomal protein L44provided by HGNC
Primary source
HGNC:HGNC:16650
See related
Ensembl:ENSG00000135900 MIM:611849; AllianceGenome:HGNC:16650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mL44; L44MT; COXPD16; MRP-L44
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 7.0), lymph node (RPKM 6.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MRPL44 in Genome Data Viewer
Location:
2q36.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (223950854..223967714)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (224434103..224450970)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (224822180..224832431)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene WD repeat and FYVE domain containing 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:224786671-224787171 Neighboring gene general transcription factor IIIA pseudogene 3 Neighboring gene uncharacterized LOC124907989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17184 Neighboring gene serpin family E member 2 Neighboring gene uncharacterized LOC124907990 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:224874015-224875214 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:224879805-224880304 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17185 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17186 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:224891400-224892039 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:224892040-224892678 Neighboring gene uncharacterized LOC124907991 Neighboring gene Sharpr-MPRA regulatory region 13948

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mitochondrial ribosomal protein L44 (MRPL44) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ12701, FLJ13990, FLJ37688

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables ribonuclease III activity IKR
Inferred from Key Residues
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial translational elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of microprocessor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
large ribosomal subunit protein mL44
Names
39S ribosomal protein L44, mitochondrial
mitochondrial large ribosomal subunit protein mL44
NP_075066.1
XP_011509970.1
XP_054199444.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050679.2 RefSeqGene

    Range
    11611..21862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022915.5NP_075066.1  large ribosomal subunit protein mL44

    See identical proteins and their annotated locations for NP_075066.1

    Status: REVIEWED

    Source sequence(s)
    AC073641
    Consensus CDS
    CCDS2459.1
    UniProtKB/Swiss-Prot
    Q53S16, Q6IA62, Q9H821, Q9H9J2
    Related
    ENSP00000258383.3, ENST00000258383.4
    Conserved Domains (2) summary
    cd19874
    Location:225307
    DSRM_MRPL44; double-stranded RNA binding motif of mitochondrial 39S ribosomal protein L44 (MRPL44) and similar proteins
    cl00258
    Location:117222
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    223950854..223967714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511668.3XP_011509970.1  large ribosomal subunit protein mL44 isoform X1

    Conserved Domains (2) summary
    pfam00636
    Location:115193
    Ribonuclease_3; Ribonuclease III domain
    cl00054
    Location:222290
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    224434103..224450970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343469.1XP_054199444.1  large ribosomal subunit protein mL44 isoform X1