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MRPL44 mitochondrial ribosomal protein L44 [ Homo sapiens (human) ]

Gene ID: 65080, updated on 9-Jan-2022

Summary

Official Symbol
MRPL44provided by HGNC
Official Full Name
mitochondrial ribosomal protein L44provided by HGNC
Primary source
HGNC:HGNC:16650
See related
Ensembl:ENSG00000135900 MIM:611849
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L44MT; COXPD16; MRP-L44
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 7.0), lymph node (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

See MRPL44 in Genome Data Viewer
Location:
2q36.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (223950846..223967714)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (224822180..224832431)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2258 Neighboring gene adaptor related protein complex 1 subunit sigma 3 Neighboring gene WD repeat and FYVE domain containing 1 Neighboring gene general transcription factor IIIA pseudogene 3 Neighboring gene serpin family E member 2 Neighboring gene Sharpr-MPRA regulatory region 13948

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mitochondrial ribosomal protein L44 (MRPL44) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12701, FLJ13990, FLJ37688

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables ribonuclease III activity IKR
Inferred from Key Residues
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial translational elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
39S ribosomal protein L44, mitochondrial
Names
mitochondrial large ribosomal subunit protein mL44
NP_075066.1
XP_011509970.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050679.1 RefSeqGene

    Range
    11515..21825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022915.5NP_075066.1  39S ribosomal protein L44, mitochondrial

    See identical proteins and their annotated locations for NP_075066.1

    Status: REVIEWED

    Source sequence(s)
    AC073641
    Consensus CDS
    CCDS2459.1
    UniProtKB/Swiss-Prot
    Q9H9J2
    UniProtKB/TrEMBL
    A0A024R473
    Related
    ENSP00000258383.3, ENST00000258383.4
    Conserved Domains (2) summary
    cd19874
    Location:225307
    DSRM_MRPL44; double-stranded RNA binding motif of mitochondrial 39S ribosomal protein L44 (MRPL44) and similar proteins
    cl00258
    Location:117222
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    223950846..223967714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511668.2XP_011509970.1  39S ribosomal protein L44, mitochondrial isoform X1

    Conserved Domains (2) summary
    pfam00636
    Location:115193
    Ribonuclease_3; Ribonuclease III domain
    cl00054
    Location:222290
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
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