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MRPL44 mitochondrial ribosomal protein L44 [ Homo sapiens (human) ]

Gene ID: 65080, updated on 12-Aug-2018

Summary

Official Symbol
MRPL44provided by HGNC
Official Full Name
mitochondrial ribosomal protein L44provided by HGNC
Primary source
HGNC:HGNC:16650
See related
Ensembl:ENSG00000135900 MIM:611849; Vega:OTTHUMG00000133164
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L44MT; COXPD16; MRP-L44
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 7.0), lymph node (RPKM 6.9) and 25 other tissues See more
Orthologs

Genomic context

See MRPL44 in Genome Data Viewer
Location:
2q36.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (223950846..223967714)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (224822121..224832431)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene adaptor related protein complex 1 subunit sigma 3 Neighboring gene WD repeat and FYVE domain containing 1 Neighboring gene serpin family E member 2 Neighboring gene ubiquitin specific peptidase 21 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mitochondrial ribosomal protein L44 (MRPL44) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Mitochondrial translation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
  • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
  • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
  • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
    Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12701, FLJ13990, FLJ37688

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ribonuclease III activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial translational elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
pre-miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
primary miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
production of siRNA involved in RNA interference IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
39S ribosomal protein L44, mitochondrial
Names
mitochondrial large ribosomal subunit protein mL44
NP_075066.1
XP_011509970.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050679.1 RefSeqGene

    Range
    11515..21825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022915.3NP_075066.1  39S ribosomal protein L44, mitochondrial

    See identical proteins and their annotated locations for NP_075066.1

    Status: REVIEWED

    Source sequence(s)
    AA814344, AL703412, BC012058, CB132022
    Consensus CDS
    CCDS2459.1
    UniProtKB/Swiss-Prot
    Q9H9J2
    UniProtKB/TrEMBL
    A0A024R473
    Related
    ENSP00000258383.3, OTTHUMP00000164216, ENST00000258383.3, OTTHUMT00000256866
    Conserved Domains (1) summary
    cl25983
    Location:86305
    Rnc; dsRNA-specific ribonuclease [Transcription]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    223950846..223967714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511668.2XP_011509970.1  39S ribosomal protein L44, mitochondrial isoform X1

    Conserved Domains (2) summary
    pfam00636
    Location:115193
    Ribonuclease_3; Ribonuclease III domain
    cl00054
    Location:222290
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
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