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Mrpl44 mitochondrial ribosomal protein L44 [ Mus musculus (house mouse) ]

Gene ID: 69163, updated on 30-Apr-2024

Summary

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Official Symbol
Mrpl44provided by MGI
Official Full Name
mitochondrial ribosomal protein L44provided by MGI
Primary source
MGI:MGI:1916413
See related
Ensembl:ENSMUSG00000026248 AllianceGenome:MGI:1916413
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810030E18Rik; 5730593H20Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translational elongation. Predicted to be located in nuclear body and plasma membrane. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; sensory organ; and spleen. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 16. Orthologous to human MRPL44 (mitochondrial ribosomal protein L44). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 10.3), heart adult (RPKM 9.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrpl44 in Genome Data Viewer
Location:
1 C4; 1 40.96 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (79753735..79759162)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (79776018..79781445)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01444 Neighboring gene predicted gene, 24160 Neighboring gene STARR-seq mESC enhancer starr_01445 Neighboring gene STARR-seq mESC enhancer starr_01446 Neighboring gene adaptor-related protein complex AP-1, sigma 3 Neighboring gene STARR-positive B cell enhancer ABC_E10017 Neighboring gene STARR-positive B cell enhancer ABC_E3283 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:79707879-79708032 Neighboring gene WD repeat and FYVE domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_01447 Neighboring gene STARR-positive B cell enhancer ABC_E4328 Neighboring gene STARR-positive B cell enhancer mm9_chr1:79772314-79772614 Neighboring gene predicted gene, 39666 Neighboring gene serine (or cysteine) peptidase inhibitor, clade E, member 2 Neighboring gene STARR-seq mESC enhancer starr_01448 Neighboring gene STARR-seq mESC enhancer starr_01449

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Richman TR, et al. Nat Commun, 2016 Jun 20. PMID 27319982, Free PMC Article
  2. DDX1 vesicles control calcium-dependent mitochondrial activity in mouse embryos. Wang Y, et al. Nat Commun, 2022 Jul 1. PMID 35778392, Free PMC Article
  3. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
  4. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  5. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonuclease III activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translational elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of microprocessor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein mL44
Names
39S ribosomal protein L44, mitochondrial
L44mt
MRP-L44
NP_001074679.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081210.1 → NP_001074679.1  large ribosomal subunit protein mL44 precursor

    See identical proteins and their annotated locations for NP_001074679.1

    Status: PROVISIONAL

    Source sequence(s)
    AC170750
    Consensus CDS
    CCDS35629.1
    UniProtKB/Swiss-Prot
    Q3U0J0, Q8VE61, Q9CY73
    UniProtKB/TrEMBL
    Q3UKG1
    Related
    ENSMUSP00000027464.9, ENSMUST00000027464.9
    Conserved Domains (2) summary
    COG0571
    Location:77 → 305
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cl00054
    Location:236 → 304
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    79753735..79759162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026970.1: Suppressed sequence

    Description
    NM_026970.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CY73.3 GenPept UniProtKB/Swiss-Prot:Q9CY73

Gene LinkOut

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