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Mrpl44 mitochondrial ribosomal protein L44 [ Mus musculus (house mouse) ]

Gene ID: 69163, updated on 8-Dec-2022

Summary

Official Symbol
Mrpl44provided by MGI
Official Full Name
mitochondrial ribosomal protein L44provided by MGI
Primary source
MGI:MGI:1916413
See related
Ensembl:ENSMUSG00000026248 AllianceGenome:MGI:1916413
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810030E18Rik; 5730593H20Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translational elongation. Predicted to be located in nuclear body and plasma membrane. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in mitochondrion. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; sensory organ; and spleen. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 16. Orthologous to human MRPL44 (mitochondrial ribosomal protein L44). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 10.3), heart adult (RPKM 9.7) and 28 other tissues See more
Orthologs
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Genomic context

See Mrpl44 in Genome Data Viewer
Location:
1; 1 C4
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (79753735..79759162)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (79776018..79781445)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24160 Neighboring gene adaptor-related protein complex AP-1, sigma 3 Neighboring gene WD repeat and FYVE domain containing 1 Neighboring gene predicted gene, 39666 Neighboring gene serine (or cysteine) peptidase inhibitor, clade E, member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonuclease III activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial translational elongation ISO
Inferred from Sequence Orthology
more info
 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
39S ribosomal protein L44, mitochondrial
Names
L44mt
MRP-L44
NP_001074679.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081210.1NP_001074679.1  39S ribosomal protein L44, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001074679.1

    Status: PROVISIONAL

    Source sequence(s)
    AC170750
    Consensus CDS
    CCDS35629.1
    UniProtKB/Swiss-Prot
    Q8VE61, Q9CY73
    Related
    ENSMUSP00000027464.9, ENSMUST00000027464.9
    Conserved Domains (2) summary
    COG0571
    Location:77305
    Rnc; dsRNA-specific ribonuclease [Transcription]
    cl00054
    Location:236304
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    79753735..79759162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026970.1: Suppressed sequence

    Description
    NM_026970.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.