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GZF1 GDNF inducible zinc finger protein 1 [ Homo sapiens (human) ]

Gene ID: 64412, updated on 5-Aug-2022

Summary

Official Symbol
GZF1provided by HGNC
Official Full Name
GDNF inducible zinc finger protein 1provided by HGNC
Primary source
HGNC:HGNC:15808
See related
Ensembl:ENSG00000125812 MIM:613842; AllianceGenome:HGNC:15808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JLSM; ZBTB23; ZNF336
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 10.9), bone marrow (RPKM 10.5) and 25 other tissues See more
Orthologs
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Genomic context

See GZF1 in Genome Data Viewer
Location:
20p11.21
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (23361127..23373062)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (23421722..23432602)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (23342819..23353699)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene NXT1 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 1431 Neighboring gene nuclear transport factor 2 like export factor 1 Neighboring gene RNA, 5S ribosomal pseudogene 479 Neighboring gene NSF attachment protein beta Neighboring gene cystatin like 1 Neighboring gene cystatin 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
GDNF-inducible zinc finger protein 1
Names
zinc finger and BTB domain-containing protein 23
zinc finger protein 336

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317012.2NP_001303941.1  GDNF-inducible zinc finger protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AA062926, AK025447, AK056477, AK289814, AL096677, BM975844, DA229844
    Consensus CDS
    CCDS13151.1
    UniProtKB/Swiss-Prot
    Q9H116, Q9H6W6
    Conserved Domains (3) summary
    COG5048
    Location:405593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21133
    BTB; BTB/POZ domain
  2. NM_001317019.1NP_001303948.1  GDNF-inducible zinc finger protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon, resulting in a novel 3' coding region and a distinct 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK056477, AL096677, BC154409, BM975844
    UniProtKB/Swiss-Prot
    Q9H116
    Conserved Domains (6) summary
    smart00225
    Location:32133
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:517677
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21125
    BTB; BTB/POZ domain
    pfam13465
    Location:449474
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:437540
    zf-C2H2_8; C2H2-type zinc ribbon
  3. NM_022482.5NP_071927.1  GDNF-inducible zinc finger protein 1 isoform a

    See identical proteins and their annotated locations for NP_071927.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AA062926, AK025447, AK056159, AK056477, AL096677, BM975844
    Consensus CDS
    CCDS13151.1
    UniProtKB/Swiss-Prot
    Q9H116, Q9H6W6
    Related
    ENSP00000338290.5, ENST00000338121.10
    Conserved Domains (3) summary
    COG5048
    Location:405593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21133
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    23361127..23373062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440376.1XP_047296332.1  GDNF-inducible zinc finger protein 1 isoform X2

  2. XM_011529321.4XP_011527623.1  GDNF-inducible zinc finger protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527623.1

    UniProtKB/Swiss-Prot
    Q9H116, Q9H6W6
    Conserved Domains (3) summary
    COG5048
    Location:405593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21133
    BTB; BTB/POZ domain
  3. XM_011529322.3XP_011527624.1  GDNF-inducible zinc finger protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011527624.1

    UniProtKB/Swiss-Prot
    Q9H116, Q9H6W6
    Related
    ENSP00000366250.2, ENST00000377051.2
    Conserved Domains (3) summary
    COG5048
    Location:405593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21133
    BTB; BTB/POZ domain
  4. XM_017028018.3XP_016883507.1  GDNF-inducible zinc finger protein 1 isoform X2

    Conserved Domains (6) summary
    smart00225
    Location:32133
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:517677
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21125
    BTB; BTB/POZ domain
    pfam13465
    Location:449474
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:437540
    zf-C2H2_8; C2H2-type zinc ribbon
  5. XM_017028019.3XP_016883508.1  GDNF-inducible zinc finger protein 1 isoform X3

    Conserved Domains (5) summary
    smart00225
    Location:32133
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21125
    BTB; BTB/POZ domain
    pfam13465
    Location:449474
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:437543
    zf-C2H2_8; C2H2-type zinc ribbon
  6. XM_024451968.2XP_024307736.1  GDNF-inducible zinc finger protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9H6W6
    Conserved Domains (3) summary
    COG5048
    Location:405593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21133
    BTB; BTB/POZ domain
  7. XM_047440375.1XP_047296331.1  GDNF-inducible zinc finger protein 1 isoform X2

  8. XM_024451969.2XP_024307737.1  GDNF-inducible zinc finger protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9H6W6
    Conserved Domains (3) summary
    COG5048
    Location:405593
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21133
    BTB; BTB/POZ domain
  9. XM_017028017.3XP_016883506.1  GDNF-inducible zinc finger protein 1 isoform X2

    Conserved Domains (6) summary
    smart00225
    Location:32133
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:517677
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21125
    BTB; BTB/POZ domain
    pfam13465
    Location:449474
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:437540
    zf-C2H2_8; C2H2-type zinc ribbon
  10. XM_005260800.4XP_005260857.1  GDNF-inducible zinc finger protein 1 isoform X2

    Conserved Domains (6) summary
    smart00225
    Location:32133
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:517677
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21125
    BTB; BTB/POZ domain
    pfam13465
    Location:449474
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:437540
    zf-C2H2_8; C2H2-type zinc ribbon
  11. XM_005260802.5XP_005260859.1  GDNF-inducible zinc finger protein 1 isoform X3

    Conserved Domains (5) summary
    smart00225
    Location:32133
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:409429
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:21125
    BTB; BTB/POZ domain
    pfam13465
    Location:449474
    zf-H2C2_2; Zinc-finger double domain
    pfam15909
    Location:437543
    zf-C2H2_8; C2H2-type zinc ribbon
  12. XM_047440378.1XP_047296334.1  GDNF-inducible zinc finger protein 1 isoform X4

  13. XM_047440377.1XP_047296333.1  GDNF-inducible zinc finger protein 1 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    23421722..23432602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)