4EOZ,2Z8H,1R28,3M8V,3B84,1BUO,5EUP,4CXI


Conserved Protein Domain Family
BTB

?
pfam00651: BTB (this model, PSSM-Id:306997 is obsolete and has been replaced by 334194)
Click on image for an interactive view with Cn3D
BTB/POZ domain
The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Statistics
?
PSSM-Id: 306997
View PSSM: pfam00651
Aligned: 86 rows
Threshold Bit Score: 63.8233
Threshold Setting Gi: 1723292
Created: 12-Jul-2016
Updated: 4-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
4EOZ_A   16 LGGLWEN---SRFTDCCLCVagQEFQAHKAILAARSPVFSAMFEHE----------MEESKKNr--VEINDVEPEVFKEM 80   human
O74881  608 LTSYENYk-qSFSDVTIYCGt-SMFHSHKFILCARSSFLRKLLLQKkkssvsniiyIEEITQShstIRVEDIPPLAVAIL 685  Schizosaccharomyces...
Q01295   22 FENLRDDe--AFVDVTLACEg-RSIKAHRVVLSACSPYFRELLKSTp----------CKHPVIl--L--QDVNFMDLHAL 84   fruit fly
Q9W0K7  117 FDQLLQNe--CFVDVTLACDg-RSMKAHKMVLSACSPYFQTLLAETp----------CQHPi----VIMRDVNWSDLKAI 179  fruit fly
P17789   23 FDQLLHAe--TFTDVTLAVEg-QHLKAHKMVLSACSPYFNTLFVSHp----------EKHPIVi--L--KDVPYSDMKSL 85   fruit fly
Q86B87   22 FHESLCRg--DLVDVSLAAEg-QIVKAHRLVLSVCSPFFRKMFTQMp---------sNTHAIVf--L--NNVSHSALKDL 85   fruit fly
P42284   22 FDTLLENe--TLVDCTLAAEg-KFLKAHKVVLSACSPYFATLLQEQy----------DKHPIFi--L--KDVKYQELRAM 84   fruit fly
Q24174   93 FRHLRDEe--DFVDVTLACDe-RSFTAHKVVLSACSPYFRRLLKANp----------CEHPIVi--L--RDVRCDDVENL 155  fruit fly
Q19838   23 LQAKRRAgdfSTCDVKIQLKt-GFDMVHSVVICAHSDVFSETFDNQ-----------RAPYQP---FNMTDFDPDSVRRV 87   Caenorhabditis elegans
Q10225  296 LNQPSDQy--SFHDAYLQSYt-HRYPVHRAIMCRCEYFLDMLAGPFl---------eSNQELP---VLSLPFSSSVVEIV 360  Schizosaccharomyces...
4EOZ_A   81 MCFIYTGk-------aPNLDKMADDLLAAaDKYALERLKVMCEDALCSNL 123  human
O74881  686 LHYLYTDtllspwhldSRFSPLKENLSKLaNLLELPHLAEVLPFSVSRQP 735  Schizosaccharomyces pombe 972h-
Q01295   85 VEFIYHGevn---vhqKS---LQSFLKTA-EVLRVSGLTQQQAEDTHSHL 127  fruit fly
Q9W0K7  180 VEFMYRGein---vsqDQ---IGPLLRIA-EMLKVRGLADVTHMEAATAA 222  fruit fly
P17789   86 LDFMYRGevs---vdqER---LTAFLRVA-ESLRIKGLTEVNDDK-PSPA 127  fruit fly
Q86B87   86 IQFMYCGevn---vkqDA---LPAFISTA-ESLQIKGLTDNDPAPQPPQE 128  fruit fly
P42284   85 MDYMYRGevn---isqDQ---LAALLKAA-ESLQIKGLSDNRTGGGVAPK 127  fruit fly
Q24174  156 LSFMYNGevn---vshEQ---LPDFLKTA-HLLQIRGLADVNGGYPYSKA 198  fruit fly
Q19838   88 FDWMYSGeid------ipETTIADVLAVA-SYLRVTMLQRQIEQKILNHN 130  Caenorhabditis elegans
Q10225  361 LKFLYTDktd-----iaPELALDVVYVADmLSLDKDRSLKSLASIVITKQ 405  Schizosaccharomyces pombe 972h-
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap