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MAP2K4 mitogen-activated protein kinase kinase 4 [ Homo sapiens (human) ]

Gene ID: 6416, updated on 29-Mar-2020

Summary

Official Symbol
MAP2K4provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase 4provided by HGNC
Primary source
HGNC:HGNC:6844
See related
Ensembl:ENSG00000065559 MIM:601335
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JNKK; MEK4; MKK4; SEK1; SKK1; JNKK1; SERK1; MAPKK4; PRKMK4; SAPKK1; SAPKK-1
Summary
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in brain (RPKM 23.5), thyroid (RPKM 10.1) and 25 other tissues See more
Orthologs

Genomic context

See MAP2K4 in Genome Data Viewer
Location:
17p12
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (12020822..12143828)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (11924135..12047148)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 9 Neighboring gene uncharacterized LOC101928350 Neighboring gene ribosomal protein L21 pseudogene 122 Neighboring gene zinc finger protein 18 Neighboring gene RNA, U11 small nuclear 2, pseudogene Neighboring gene dynein light chain Tctex-type 1 pseudogene Neighboring gene microRNA 744 Neighboring gene uncharacterized LOC105371540 Neighboring gene long intergenic non-protein coding RNA 670 Neighboring gene MYOCD antisense RNA 1 Neighboring gene myocardin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
JUN kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase kinase kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
JNK cascade TAS
Traceable Author Statement
more info
 
activation of JUN kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to sorbitol IEA
Inferred from Electronic Annotation
more info
 
negative regulation of motor neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nitric-oxide synthase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 4
Names
JNK-activated kinase 1
JNK-activating kinase 1
MAP kinase kinase 4
MAPK/ERK kinase 4
MAPKK 4
MEK 4
SAPK/ERK kinase 1
c-Jun N-terminal kinase kinase 1
stress-activated protein kinase kinase 1
NP_001268364.1
NP_003001.1
XP_005256810.1
XP_005256812.1
XP_011522278.1
XP_011522279.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033952.1 RefSeqGene

    Range
    5060..128011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001281435.2NP_001268364.1  dual specificity mitogen-activated protein kinase kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_001268364.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is longer compared to isoform 1.
    Source sequence(s)
    AC005244, AC005410, AK131544
    Consensus CDS
    CCDS62095.1
    UniProtKB/Swiss-Prot
    P45985
    Related
    ENSP00000410402.3, ENST00000415385.7
    Conserved Domains (1) summary
    cd06616
    Location:106396
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
  2. NM_003010.4NP_003001.1  dual specificity mitogen-activated protein kinase kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_003001.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AU150695, BC036032, BQ028457, L36870
    Consensus CDS
    CCDS11162.1
    UniProtKB/Swiss-Prot
    P45985
    Related
    ENSP00000262445.5, ENST00000353533.10
    Conserved Domains (1) summary
    cd06616
    Location:95385
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    12020822..12143828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256755.2XP_005256812.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X3

    See identical proteins and their annotated locations for XP_005256812.1

    Conserved Domains (2) summary
    smart00220
    Location:6221
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1239
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011523977.2XP_011522279.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X3

    See identical proteins and their annotated locations for XP_011522279.1

    Conserved Domains (2) summary
    smart00220
    Location:6221
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1239
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011523976.2XP_011522278.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:114310
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:106309
    PKc_like; Protein Kinases, catalytic domain
  4. XM_005256753.3XP_005256810.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X2

    See identical proteins and their annotated locations for XP_005256810.1

    Conserved Domains (1) summary
    cd06616
    Location:1267
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

RNA

  1. XR_934080.2 RNA Sequence

  2. XR_001752584.2 RNA Sequence

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