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Map2k4 mitogen-activated protein kinase kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 26398, updated on 8-Feb-2024

Summary

Official Symbol
Map2k4provided by MGI
Official Full Name
mitogen-activated protein kinase kinase 4provided by MGI
Primary source
MGI:MGI:1346869
See related
Ensembl:ENSMUSG00000033352 AllianceGenome:MGI:1346869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MEK4; MKK4; Sek1; JNKK1; Serk1; PRKMK4; MAPKK 4
Summary
Predicted to enable ATP binding activity; JUN kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in positive regulation of smooth muscle cell apoptotic process. Acts upstream of or within MAPK cascade; negative regulation of motor neuron apoptotic process; and response to wounding. Predicted to be located in several cellular components, including axon; dendrite cytoplasm; and perikaryon. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system cancer (multiple); and urinary bladder cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 19.2), cortex adult (RPKM 18.8) and 28 other tissues See more
Orthologs
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Genomic context

See Map2k4 in Genome Data Viewer
Location:
11 B3; 11 40.53 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (65579070..65679185, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (65688244..65788359, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm85 Neighboring gene predicted gene, 26128 Neighboring gene predicted gene, 30786 Neighboring gene predicted gene, 40026 Neighboring gene STARR-seq mESC enhancer starr_29772 Neighboring gene microRNA 744 Neighboring gene predicted gene, 53682 Neighboring gene zinc finger with KRAB and SCAN domains 6 Neighboring gene dynein, axonemal, heavy chain 9 Neighboring gene STARR-seq mESC enhancer starr_29773 Neighboring gene STARR-seq mESC enhancer starr_29774 Neighboring gene predicted gene, 40027

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables JUN kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within MAPK cascade IPI
Inferred from Physical Interaction
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dual specificity mitogen-activated protein kinase kinase 4
Names
C-JUN N-terminal kinase kinase 1
JNK kinase 1
JNK-activating kinase 1
MAP kinase kinase 4
MAPK/ERK kinase 4
SAPK/ERK kinase 1
SAPK/Erk/kinase 1
NP_001303296.1
NP_001303297.1
NP_001303298.1
NP_001349668.1
NP_001349669.1
NP_033183.1
XP_011247335.1
XP_030101878.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316367.1NP_001303296.1  dual specificity mitogen-activated protein kinase kinase 4 isoform a

    Status: VALIDATED

    Source sequence(s)
    AK036928, AK139777, AL662895, BY277234
    UniProtKB/TrEMBL
    Q543X6
    Conserved Domains (1) summary
    cd06616
    Location:104394
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
  2. NM_001316368.1NP_001303297.1  dual specificity mitogen-activated protein kinase kinase 4 isoform c

    Status: VALIDATED

    Source sequence(s)
    AK036928, AL662895, BY244326, BY277234
    UniProtKB/TrEMBL
    Q543X6
    Conserved Domains (1) summary
    cl21453
    Location:1239
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001316369.1NP_001303298.1  dual specificity mitogen-activated protein kinase kinase 4 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate 5' exons compared to variant 1, that causes translation initiation from a downstream AUG. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AK036928, AL662895, BY277234, CB723868
    UniProtKB/TrEMBL
    Q543X6
    Conserved Domains (1) summary
    cl21453
    Location:1239
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001362739.1NP_001349668.1  dual specificity mitogen-activated protein kinase kinase 4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL662895, AL663069
    UniProtKB/TrEMBL
    Q8K2U0
    Conserved Domains (1) summary
    cd06616
    Location:1267
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
  5. NM_001362740.1NP_001349669.1  dual specificity mitogen-activated protein kinase kinase 4 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL662895, AL663069
    UniProtKB/TrEMBL
    Q8K2U0
    Conserved Domains (1) summary
    cd06616
    Location:1267
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
  6. NM_009157.5NP_033183.1  dual specificity mitogen-activated protein kinase kinase 4 isoform b

    See identical proteins and their annotated locations for NP_033183.1

    Status: VALIDATED

    Source sequence(s)
    AK036928, AL662895, BY277234
    Consensus CDS
    CCDS24844.1
    UniProtKB/Swiss-Prot
    P47809
    UniProtKB/TrEMBL
    Q543X6
    Related
    ENSMUSP00000041282.4, ENSMUST00000046963.10
    Conserved Domains (1) summary
    cd06616
    Location:93383
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    65579070..65679185 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246018.1XP_030101878.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    Q8K2U0
    Conserved Domains (1) summary
    cd06616
    Location:1267
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
  2. XM_011249033.3XP_011247335.1  dual specificity mitogen-activated protein kinase kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_011247335.1

    UniProtKB/TrEMBL
    Q8K2U0
    Conserved Domains (1) summary
    cd06616
    Location:1267
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4