NOD2 nucleotide binding oligomerization domain containing 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NOD2provided by HGNC
Official Full Name: nucleotide binding oligomerization domain containing 2provided by HGNC
Primary source: HGNC:HGNC:5331
See related: Ensembl:ENSG00000167207 MIM:605956
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CD; ACUG; BLAU; IBD1; YAOS; BLAUS; NLRC2; NOD2B; CARD15; CLR16.3; PSORAS1
Summary: This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Expression: Broad expression in bone marrow (RPKM 3.3), appendix (RPKM 2.5) and 16 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 16q12.1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
109.20200228	current	GRCh38.p13 (GCF_000001405.39)	16	NC_000016.10 (50693587..50733077)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (50727507..50766990)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mRNA expression of NOD2 was not enhanced in asthma patients compared to controls. The distribution of NOD2 rs2066844, rs2066845, rs2066847 SNPs did not show significant differences between asthma cases and control groups.
Title: Gene Variants, mRNA and NOD1/2 Protein Levels in Tunisian Childhood Asthma.
NOD2 risk variants are associated with bacterial infections (BI) in cirrhosis. The genetic effect on BI is strongest in compensated patients, whereas in decompensated patients their presence is less relevant. In this situation, clinically significant portal hypertension becomes an independent factor associated with BI.
Title: Common NOD2 Risk Variants as Major Susceptibility Factors for Bacterial Infections in Compensated Cirrhosis.
Results demonstrate that 29-kDa FN-f modulated pro-catabolic responses via cross-regulation of NOD2 and TLR-2 signaling pathways.
Title: NOD2 signaling pathway is involved in fibronectin fragment-induced pro-catabolic factor expressions in human articular chondrocytes.
NOD2 c.2857A > G p.K953E polymorphism may be correlated with PD susceptibility in Chinese Han population
Title: Association between nucleotide-binding oligomerization domain protein 2 (<i>NOD2</i>) gene polymorphisms and Parkinson's disease (PD) susceptibility.
HIV slow progressors with variants in the TLR and NOD2 pathways showed reduced pro-inflammatory responses compared to matched controls. Low-range plasma levels of fibronectin was observed in a LTNP harboring two FN1 variants.
Title: Whole Exome Sequencing of HIV-1 long-term non-progressors identifies rare variants in genes encoding innate immune sensors and signaling molecules.
The antimicrobial actions of PALA required expression of nucleotide-binding, oligomerization domain 2 (NOD2), receptor-interacting serine/threonine-protein kinase 2 (RIP2), and carbamoyl phosphatase synthase II/aspartate transcarbamylase/dihydroorotase (CAD).
Title: Pyrimidine synthesis inhibition enhances cutaneous defenses against antibiotic resistant bacteria through activation of NOD2 signaling.
This study demonstrates for the first time that NOD2 expression and pathway activation are aberrant in YAOS syndrome, and specific NOD2 genotypes result in distinct NOD2 expression and cytokine profiles.
Title: Alterations in nucleotide-binding oligomerization domain-2 expression, pathway activation, and cytokine production in Yao syndrome.
study exemplifies how targeting of the ATP-binding pocket in RIPK2 can be exploited to interfere with the RIPK2-XIAP interaction for modulation of NOD signaling.
Title: Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.
NOD2 genotypes were not associated with microbial composition and diversity.
Title: IL23R-Protective Coding Variant Promotes Beneficial Bacteria and Diversity in the Ileal Microbiome in Healthy Individuals Without Inflammatory Bowel Disease.
NOD2 is crucial to control intracellular infection caused by Leishmania spp. NOD2 receptor is important for Leishmania recognition, the control of intracellular killing, and the induction of innate and adaptive immune responses.
Title: The NOD2 receptor is crucial for immune responses towards New World Leishmania species.

Submit: New GeneRIF Correction See all GeneRIFs (618)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Blau syndrome MedGen: C1861303 OMIM: 186580 GeneReviews: Not available	Compare labs
Inflammatory bowel disease 1 MedGen: C0678202 OMIM: 266600 GeneReviews: Not available	Compare labs
Yao syndrome MedGen: C4310620 OMIM: 617321 GeneReviews: Not available	Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genomewide association study of leprosy. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Systematic association mapping identifies NELL1 as a novel IBD disease gene. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr upregulates the gene expression of NOD2 in human monocyte-derived dendritic cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16S514 (e-PCR)
- UniSTS:20238

D16S419 (e-PCR), detects polymorphism
- UniSTS:21834

D16S503 (e-PCR)
- UniSTS:16470

D16S3393 (e-PCR), detects polymorphism
- UniSTS:14682

D16S411 (e-PCR), detects polymorphism
- UniSTS:50013

D16S2874 (e-PCR)
- UniSTS:153444

D16S2885 (e-PCR)
- UniSTS:153455

PMC356064P1 (e-PCR)
- UniSTS:273265

D16S267 (e-PCR), detects polymorphism
- UniSTS:146811

G67955 (e-PCR)
- UniSTS:225676

G67947 (e-PCR)
- UniSTS:225677

G67948 (e-PCR)
- UniSTS:225678

G67949 (e-PCR)
- UniSTS:225679

G67950 (e-PCR)
- UniSTS:225680

G67951 (e-PCR)
- UniSTS:225681

G67952 (e-PCR)
- UniSTS:225682

G67946 (e-PCR)
- UniSTS:225684

D16S408 (e-PCR), detects polymorphism
- UniSTS:24999

D16S2730 (e-PCR)
- UniSTS:153300

G09530 (e-PCR)
- UniSTS:6367

D16S409 (e-PCR), detects polymorphism
- UniSTS:20195

D16S753 (e-PCR), detects polymorphism
- UniSTS:26598

D16S3089 (e-PCR), detects polymorphism
- UniSTS:75496

D16S415 (e-PCR)
- UniSTS:30459

Homology

Homologs of the NOD2 gene: The NOD2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and zebrafish.
Orthologs from Annotation Pipeline: 214 organisms have orthologs with human gene NOD2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
CARD domain binding	IPI Inferred from Physical Interaction more info	PubMed
Hsp70 protein binding	IPI Inferred from Physical Interaction more info	PubMed
Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
actin binding	IDA Inferred from Direct Assay more info	PubMed
enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
muramyl dipeptide binding	IDA Inferred from Direct Assay more info	PubMed
peptidoglycan binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
JNK cascade	TAS Traceable Author Statement more info
activation of MAPK activity	TAS Traceable Author Statement more info
cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to muramyl dipeptide	IDA Inferred from Direct Assay more info	PubMed
cellular response to muramyl dipeptide	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
cellular response to peptidoglycan	IEA Inferred from Electronic Annotation more info
cytokine production involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
cytokine secretion involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
defense response	TAS Traceable Author Statement more info	PubMed
defense response to bacterium	IBA Inferred from Biological aspect of Ancestor more info	PubMed
defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
detection of bacterium	IDA Inferred from Direct Assay more info	PubMed
detection of biotic stimulus	TAS Traceable Author Statement more info	PubMed
detection of muramyl dipeptide	IDA Inferred from Direct Assay more info	PubMed
innate immune response	IDA Inferred from Direct Assay more info	PubMed
innate immune response	NAS Non-traceable Author Statement more info	PubMed
interleukin-1-mediated signaling pathway	TAS Traceable Author Statement more info
intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
maintenance of gastrointestinal epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of macrophage apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
nucleotide-binding oligomerization domain containing 2 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
nucleotide-binding oligomerization domain containing signaling pathway	TAS Traceable Author Statement more info
positive regulation of B cell activation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of NF-kappaB transcription factor activity	TAS Traceable Author Statement more info
positive regulation of NIK/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cytokine production involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
positive regulation of dendritic cell antigen processing and presentation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of dendritic cell cytokine production	IEA Inferred from Electronic Annotation more info
positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of gamma-delta T cell activation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of interleukin-1 beta secretion	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-10 production	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of interleukin-17 production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of interleukin-8 production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of nitric-oxide synthase biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of oxidoreductase activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of phosphatidylinositol 3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of prostaglandin-E synthase activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of prostaglandin-endoperoxide synthase activity	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of protein K63-linked ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of stress-activated MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of type 2 immune response	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of inflammatory response	IC Inferred by Curator more info	PubMed
response to muramyl dipeptide	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to muramyl dipeptide	IDA Inferred from Direct Assay more info	PubMed
response to muramyl dipeptide	IMP Inferred from Mutant Phenotype more info	PubMed
response to nutrient	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Golgi apparatus	IDA Inferred from Direct Assay more info
basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
cell surface	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	TAS Traceable Author Statement more info	PubMed
cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
cytosol	TAS Traceable Author Statement more info
mitochondrion	IEA Inferred from Electronic Annotation more info
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nucleotide-binding oligomerization domain-containing protein 2

Names: NLR family, CARD domain containing 2; NOD-like receptor C2; caspase recruitment domain family, member 15; caspase recruitment domain protein 15; caspase recruitment domain-containing protein 15; inflammatory bowel disease protein 1; nucleotide-binding oligomerization domain 2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007508.1 RefSeqGene

Range

5001..40939

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_177

mRNA and Protein(s)

NM_001293557.2 → NP_001280486.1 nucleotide-binding oligomerization domain-containing protein 2 isoform 2

See identical proteins and their annotated locations for NP_001280486.1

Status: REVIEWED

Source sequence(s)

AC007608, AC007728

Consensus CDS

CCDS86525.1

UniProtKB/Swiss-Prot

Q9HC29

Conserved Domains (6) summary

cd08788
Location:107 → 187

CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2

sd00033
Location:793 → 817

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:737 → 764

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:266 → 436

NACHT; NACHT domain

cl14633
Location:7 → 92

DD; Death Domain Superfamily of protein-protein interaction domains

cl29113
Location:740 → 1005

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_001370466.1 → NP_001357395.1 nucleotide-binding oligomerization domain-containing protein 2 isoform 2

Status: REVIEWED

Source sequence(s)

AC007608, AC007728

Related

ENSP00000495993.1, ENST00000647318.1

Conserved Domains (6) summary

cd08788
Location:107 → 187

CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2

sd00033
Location:793 → 817

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:737 → 764

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:266 → 436

NACHT; NACHT domain

cl14633
Location:7 → 92

DD; Death Domain Superfamily of protein-protein interaction domains

cl29113
Location:740 → 1005

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
NM_022162.3 → NP_071445.1 nucleotide-binding oligomerization domain-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_071445.1

Status: REVIEWED

Source sequence(s)

AC007608, AC007728

Consensus CDS

CCDS10746.1

UniProtKB/Swiss-Prot

Q9HC29

Related

ENSP00000300589.2, ENST00000300589.6

Conserved Domains (7) summary

COG4886
Location:795 → 1040

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:767 → 1032

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08788
Location:134 → 214

CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2

sd00033
Location:820 → 844

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:764 → 791

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:293 → 463

NACHT; NACHT domain

cl14633
Location:34 → 119

DD; Death Domain Superfamily of protein-protein interaction domains

RNA

NR_163434.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC007608, AC007728

Related

ENST00000646677.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p13 Primary Assembly

Range

50693587..50733077

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017023536.1 → XP_016879025.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X4

Conserved Domains (4) summary

cd00116
Location:545 → 810

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:598 → 622

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:542 → 569

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:71 → 241

NACHT; NACHT domain
XM_017023537.1 → XP_016879026.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X4

Conserved Domains (4) summary

cd00116
Location:545 → 810

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:598 → 622

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:542 → 569

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:71 → 241

NACHT; NACHT domain
XM_006721242.4 → XP_006721305.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X2

Conserved Domains (7) summary

COG4886
Location:768 → 985

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:753 → 977

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd08788
Location:107 → 187

CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2

sd00033
Location:793 → 817

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:737 → 752

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:266 → 436

NACHT; NACHT domain

cl14633
Location:7 → 92

DD; Death Domain Superfamily of protein-protein interaction domains
XM_011523260.3 → XP_011521562.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X6

See identical proteins and their annotated locations for XP_011521562.1

UniProtKB/TrEMBL

A0A286YF65

Conserved Domains (3) summary

cd08787
Location:7 → 92

CARD_NOD2_1_CARD15; Caspase activation and recruitment domain of NOD2, repeat 1

cd08788
Location:107 → 187

CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2

pfam05729
Location:266 → 436

NACHT; NACHT domain
XM_006721243.4 → XP_006721306.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X5

See identical proteins and their annotated locations for XP_006721306.1

UniProtKB/TrEMBL

A0A286YF65

Related

ENSP00000493088.1, ENST00000641284.1

Conserved Domains (3) summary

cd08787
Location:7 → 92

CARD_NOD2_1_CARD15; Caspase activation and recruitment domain of NOD2, repeat 1

cd08788
Location:107 → 187

CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2

pfam05729
Location:266 → 436

NACHT; NACHT domain
XM_011523261.2 → XP_011521563.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X7

See identical proteins and their annotated locations for XP_011521563.1

UniProtKB/TrEMBL

A0A286YF65

Conserved Domains (3) summary

cd08787
Location:7 → 92

CARD_NOD2_1_CARD15; Caspase activation and recruitment domain of NOD2, repeat 1

cd08788
Location:107 → 187

CARD_NOD2_2_CARD15; Caspase activation and recruitment domain of NOD2, repeat 2

pfam05729
Location:266 → 436

NACHT; NACHT domain
XM_011523259.2 → XP_011521561.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X4

Conserved Domains (4) summary

cd00116
Location:545 → 810

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:598 → 622

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:542 → 569

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:71 → 241

NACHT; NACHT domain
XM_017023538.1 → XP_016879027.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X4

Conserved Domains (4) summary

cd00116
Location:545 → 810

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:598 → 622

LRR_RI; leucine-rich repeat [structural motif]

sd00034
Location:542 → 569

LRR_AMN1; leucine-rich repeat [structural motif]

pfam05729
Location:71 → 241

NACHT; NACHT domain
XM_017023535.1 → XP_016879024.1 nucleotide-binding oligomerization domain-containing protein 2 isoform X3