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Nod2 nucleotide-binding oligomerization domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 257632, updated on 8-Feb-2024

Summary

Official Symbol
Nod2provided by MGI
Official Full Name
nucleotide-binding oligomerization domain containing 2provided by MGI
Primary source
MGI:MGI:2429397
See related
Ensembl:ENSMUSG00000055994 AllianceGenome:MGI:2429397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD; ACUG; BLAU; IBD1; Nlrc2; Card15; F830032C23Rik
Summary
Enables muramyl dipeptide binding activity. Involved in several processes, including negative regulation of macrophage apoptotic process; positive regulation of macromolecule metabolic process; and positive regulation of prostaglandin-E synthase activity. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of gene expression; and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be anchored component of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); gastrointestinal carcinoma; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 1.5), spleen adult (RPKM 1.3) and 19 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See Nod2 in Genome Data Viewer
Location:
8 C3; 8 43.51 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (89373943..89415103)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (88647315..88688474)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene naked cuticle 1 Neighboring gene STARR-positive B cell enhancer ABC_E10516 Neighboring gene STARR-seq mESC enhancer starr_22236 Neighboring gene STARR-seq mESC enhancer starr_22237 Neighboring gene STARR-positive B cell enhancer ABC_E2869 Neighboring gene sorting nexin 20 Neighboring gene STARR-positive B cell enhancer ABC_E3791 Neighboring gene STARR-positive B cell enhancer ABC_E6672 Neighboring gene STARR-positive B cell enhancer ABC_E108 Neighboring gene CYLD lysine 63 deubiquitinase Neighboring gene ribosomal protein S7 pseudogene Neighboring gene nucleophosmin 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (12)  1 citation
  • Endonuclease-mediated (5) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables CARD domain binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables muramyl dipeptide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables muramyl dipeptide binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables muramyl dipeptide binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables pattern recognition receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pattern recognition receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidoglycan binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within activation of immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in antibacterial innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of biosynthetic process of antibacterial peptides active against Gram-positive bacteria IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to peptidoglycan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-positive bacterium IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of biotic stimulus TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within detection of muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in host-mediated regulation of intestinal microbiota composition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immunoglobulin production involved in immunoglobulin-mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response TAS
Traceable Author Statement
more info
PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within innate immune response in mucosa IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-18 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of macrophage cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within macrophage inflammatory protein-1 alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of gastrointestinal epithelium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-18 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of macrophage apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nucleotide-binding oligomerization domain containing 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of B cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of antibacterial peptide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic cell antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendritic cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of macrophage cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of monocyte chemotactic protein-1 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric-oxide synthase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type 2 immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of xenophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of appetite IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to muramyl dipeptide IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to muramyl dipeptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to muramyl dipeptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to muramyl dipeptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to peptidoglycan IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to peptidoglycan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in temperature homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of xenophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in extrinsic component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nucleotide-binding oligomerization domain-containing protein 2
Names
caspase recruitment domain family, member 15
caspase recruitment domain-containing protein 15

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145857.2NP_665856.2  nucleotide-binding oligomerization domain-containing protein 2

    See identical proteins and their annotated locations for NP_665856.2

    Status: VALIDATED

    Source sequence(s)
    AC156937
    Consensus CDS
    CCDS52632.1
    UniProtKB/TrEMBL
    Q80SY8, Q80SY9, Q80SZ8
    Related
    ENSMUSP00000113773.2, ENSMUST00000118370.8
    Conserved Domains (4) summary
    cd00116
    Location:753980
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:768789
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:266436
    NACHT; NACHT domain
    cl14633
    Location:107186
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    89373943..89415103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248390.3XP_011246692.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011246692.1

    UniProtKB/TrEMBL
    Q80SZ8
    Conserved Domains (6) summary
    sd00033
    Location:768789
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:266436
    NACHT; NACHT domain
    pfam17776
    Location:576730
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:518574
    NOD2_WH; NOD2 winged helix domain
    cl14633
    Location:107186
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl39015
    Location:753981
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. XM_036154050.1XP_036009943.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    Q80SZ8
    Conserved Domains (6) summary
    sd00033
    Location:762780
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:266436
    NACHT; NACHT domain
    pfam17776
    Location:576730
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:518574
    NOD2_WH; NOD2 winged helix domain
    cl14633
    Location:107186
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl39015
    Location:753979
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  3. XM_006531029.5XP_006531092.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X3

    UniProtKB/TrEMBL
    Q80SZ8
    Conserved Domains (6) summary
    sd00033
    Location:762780
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:266436
    NACHT; NACHT domain
    pfam17776
    Location:576730
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:518574
    NOD2_WH; NOD2 winged helix domain
    cl14633
    Location:107186
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl39015
    Location:753934
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  4. XM_036154051.1XP_036009944.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X4

    UniProtKB/TrEMBL
    Q3V2V8
    Related
    ENSMUST00000124091.2
    Conserved Domains (4) summary
    pfam05729
    Location:266436
    NACHT; NACHT domain
    pfam17776
    Location:576730
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:518574
    NOD2_WH; NOD2 winged helix domain
    cl14633
    Location:787
    DD; Death Domain Superfamily of protein-protein interaction domains
  5. XM_006531028.4XP_006531091.1  nucleotide-binding oligomerization domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006531091.1

    UniProtKB/TrEMBL
    Q80SZ8
    Conserved Domains (6) summary
    sd00033
    Location:768789
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:266436
    NACHT; NACHT domain
    pfam17776
    Location:576730
    NLRC4_HD2; NLRC4 helical domain HD2
    pfam17779
    Location:518574
    NOD2_WH; NOD2 winged helix domain
    cl14633
    Location:107186
    DD; Death Domain Superfamily of protein-protein interaction domains
    cl39015
    Location:753981
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...