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MAPK12 mitogen-activated protein kinase 12 [ Homo sapiens (human) ]

Gene ID: 6300, updated on 1-Jun-2020

Summary

Official Symbol
MAPK12provided by HGNC
Official Full Name
mitogen-activated protein kinase 12provided by HGNC
Primary source
HGNC:HGNC:6874
See related
Ensembl:ENSG00000188130 MIM:602399
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERK3; ERK6; ERK-6; SAPK3; PRKM12; SAPK-3; MAPK 12; P38GAMMA
Summary
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 6.0), prostate (RPKM 5.7) and 24 other tissues See more
Orthologs

Genomic context

See MAPK12 in Genome Data Viewer
Location:
22q13.33
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (50252901..50261810, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50691331..50700248, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex associated protein 6 Neighboring gene histone deacetylase 10 Neighboring gene mitogen-activated protein kinase 11 Neighboring gene plexin B2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 binding to CD4 results in activation of the mitogen-activated protein kinase (MAPK) in CD4(+) lymphocytes prestimulated through their T-cell receptor (TCR) PubMed
reverse transcriptase gag-pol MEK1 in HIV-1 producer cells is able to activate virion-associated MAPK in trans, and the activated MAPK facilitates efficient disengagement of the HIV-1 reverse transcription complex from the cell membrane and subsequent nuclear translocation PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: HDAC10

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA damage induced protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
muscle organ development TAS
Traceable Author Statement
more info
PubMed 
myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of muscle cell differentiation TAS
Traceable Author Statement
more info
 
positive regulation of peptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 12
Names
MAP kinase 12
MAP kinase p38 gamma
extracellular signal-regulated kinase 6
mitogen-activated protein kinase 3
mitogen-activated protein kinase p38 gamma
stress-activated protein kinase 3
NP_001290181.1
NP_002960.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303252.2NP_001290181.1  mitogen-activated protein kinase 12 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region compared to variant 1. This difference results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    BC015741, BX640648, CB123561, N94360, U66243, Y10487
    Consensus CDS
    CCDS77688.1
    UniProtKB/Swiss-Prot
    P53778
    UniProtKB/TrEMBL
    Q6N076
    Related
    ENSP00000479972.1, ENST00000622558.4
    Conserved Domains (2) summary
    cd07880
    Location:11343
    STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)
    smart00220
    Location:27301
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. NM_002969.6NP_002960.2  mitogen-activated protein kinase 12 isoform 1

    See identical proteins and their annotated locations for NP_002960.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC015741, CB123561, N94360, U66243, Y10487
    Consensus CDS
    CCDS14089.1
    UniProtKB/Swiss-Prot
    P53778
    Related
    ENSP00000215659.8, ENST00000215659.13
    Conserved Domains (1) summary
    cd07880
    Location:11353
    STKc_p38gamma; Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    50252901..50261810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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