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HDAC10 histone deacetylase 10 [ Homo sapiens (human) ]

Gene ID: 83933, updated on 1-Jun-2020

Summary

Official Symbol
HDAC10provided by HGNC
Official Full Name
histone deacetylase 10provided by HGNC
Primary source
HGNC:HGNC:18128
See related
Ensembl:ENSG00000100429 MIM:608544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HD10
Summary
The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in spleen (RPKM 10.7), bone marrow (RPKM 7.4) and 25 other tissues See more
Orthologs

Genomic context

See HDAC10 in Genome Data Viewer
Location:
22q13.33
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (50245183..50251265, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50683612..50689834, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373095 Neighboring gene selenoprotein O Neighboring gene tubulin gamma complex associated protein 6 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene mitogen-activated protein kinase 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MAPK12

Homology

Clone Names

  • MGC149722, DKFZp761B039

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acetylputrescine deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
acetylspermidine deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase activity TAS
Traceable Author Statement
more info
 
histone deacetylase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
chromatin organization NAS
Non-traceable Author Statement
more info
PubMed 
histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
oligodendrocyte development IEA
Inferred from Electronic Annotation
more info
 
peptidyl-lysine deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
polyamine deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mismatch repair IDA
Inferred from Direct Assay
more info
PubMed 
protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
spermidine deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polyamine deacetylase HDAC10
NP_001152758.1
NP_114408.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029758.1 RefSeqGene

    Range
    5141..11223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001159286.2NP_001152758.1  polyamine deacetylase HDAC10 isoform 2

    See identical proteins and their annotated locations for NP_001152758.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as beta) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AF407273, AF426160, BC094734
    Consensus CDS
    CCDS54545.1
    UniProtKB/Swiss-Prot
    Q969S8
    Related
    ENSP00000343540.4, ENST00000349505.4
    Conserved Domains (1) summary
    cl17011
    Location:18334
    Arginase_HDAC; Arginase-like and histone-like hydrolases
  2. NM_032019.6NP_114408.3  polyamine deacetylase HDAC10 isoform 1

    See identical proteins and their annotated locations for NP_114408.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1, also known as alpha).
    Source sequence(s)
    AF426160, BC094734
    Consensus CDS
    CCDS14088.1
    UniProtKB/Swiss-Prot
    Q969S8
    Related
    ENSP00000216271.5, ENST00000216271.10
    Conserved Domains (2) summary
    cd11683
    Location:18354
    HDAC10; Histone deacetylase 10
    cl17011
    Location:562634
    Arginase_HDAC; Arginase-like and histone-like hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    50245183..50251265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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