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BCL6 BCL6 transcription repressor [ Homo sapiens (human) ]

Gene ID: 604, updated on 2-Mar-2021

Summary

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Official Symbol
BCL6provided by HGNC
Official Full Name
BCL6 transcription repressorprovided by HGNC
Primary source
HGNC:HGNC:1001
See related
Ensembl:ENSG00000113916 MIM:109565
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCL5; LAZ3; BCL6A; ZNF51; ZBTB27
Summary
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in fat (RPKM 29.2), bone marrow (RPKM 20.1) and 25 other tissues See more
Orthologs
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Genomic context

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See BCL6 in Genome Data Viewer
Location:
3q27.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (187721377..187745472, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (187439165..187463256, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene somatostatin Neighboring gene hCG1645011-like Neighboring gene receptor transporter protein 2 Neighboring gene uncharacterized LOC105374263 Neighboring gene uncharacterized LOC105374264

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy. Fabre MS, et al. PLoS One, 2020. PMID 32320427, Free PMC Article
  2. A high-resolution landscape of mutations in the BCL6 super-enhancer in normal human B cells. Shen JC, et al. Proc Natl Acad Sci U S A, 2019 Dec 3. PMID 31748270, Free PMC Article
  3. Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia. Hurtz C, et al. Genes Dev, 2019 Sep 1. PMID 31395741, Free PMC Article
  4. [Effects of Ubiquitination on the Expression of BCL6 Protein，Cell Proliferation and Apoptosis in K562/G01 Cells]. Tang HM, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2019 Apr. PMID 30998141
  5. BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress. Fernando TM, et al. Cancer Discov, 2019 May. PMID 30777872, Free PMC Article

See all (380) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A long non-coding RNA LNBC3 facilitates non-small cell lung cancer progression by stabilizing BCL6.
    Title: A long non-coding RNA LNBC3 facilitates non-small cell lung cancer progression by stabilizing BCL6.
  2. High-grade B-Cell Lymphoma With MYC, BCL2, and/or BCL6 Translocations/Rearrangements: Clinicopathologic Features of 51 Cases in a Single Institution of South China.
    Title: High-grade B-Cell Lymphoma With MYC, BCL2, and/or BCL6 Translocations/Rearrangements: Clinicopathologic Features of 51 Cases in a Single Institution of South China.
  3. Significance of CD10 protein expression in the diagnostics of follicular lymphoma: A comparison of conventional immunohistochemistry with flow cytometry supported by the establishment of BCL2 and BCL6 rearrangements.
    Title: Significance of CD10 protein expression in the diagnostics of follicular lymphoma: A comparison of conventional immunohistochemistry with flow cytometry supported by the establishment of BCL2 and BCL6 rearrangements.
  4. Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits.
    Title: Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits.
  5. Ubiquitin-specific protease 14 regulates ovarian cancer cisplatin-resistance by stabilizing BCL6 oncoprotein.
    Title: Ubiquitin-specific protease 14 regulates ovarian cancer cisplatin-resistance by stabilizing BCL6 oncoprotein.
  6. Incidence of single hit Bcl-2 and Bcl-6 rearrangements in DLBCL: the Irish experience.
    Title: Incidence of single hit Bcl-2 and Bcl-6 rearrangements in DLBCL: the Irish experience.
  7. This makes BCL6 an excellent therapeutic target in glioblastoma.
    Title: The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy.
  8. Data support the current World Health Organization classification to define an entity with involvement of MYC , BCL2 and/or BCL6 . Although complex karyotypes are highly significant in these patients, they do not seem to have an additional high number of variants at the molecular level.
    Title: Detailed molecular analysis and evaluation of prognosis in cases with high grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements.
  9. High BCL6 expression is associated in cancers exhibiting poor prognosis.
    Title: BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress.
  10. This study displays that osteoclasts in medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy tissues feature increased expression of the higher-level regulators, paradoxically of both NFATc1 and BCL6.
    Title: Osteoclastic expression of higher-level regulators NFATc1 and BCL6 in medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis.
Submit: New GeneRIF Correction See all GeneRIFs (277)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
GeneReviews: Not available
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
GeneReviews: Not available
Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population.
GeneReviews: Not available
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
GeneReviews: Not available
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
GeneReviews: Not available
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of B-cell CLL/lymphoma 6 (BCL6) in human B cells PubMed
Tat tat HIV-1 Tat upregulates the expression of T-bet, Eomesdermin, Blimp-1, Bcl-6, and Bcl-2 in stimulated but not in unstimulated CD8+T lymphocytes PubMed
tat HIV-1 Tat upregulates the expression of BCL-6 in Kaposi's sarcoma cells and human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
  
chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
intronic transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
metal ion binding IEA
Inferred from Electronic Annotation
more info
  
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
B cell differentiation IEA
Inferred from Electronic Annotation
more info
  
Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
  
erythrocyte development IEA
Inferred from Electronic Annotation
more info
  
germinal center formation IEA
Inferred from Electronic Annotation
more info
  
inflammatory response IEA
Inferred from Electronic Annotation
more info
  
negative regulation of B cell apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
negative regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
negative regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
negative regulation of T-helper 2 cell differentiation IEA
Inferred from Electronic Annotation
more info
  
negative regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
negative regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
negative regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
  
negative regulation of isotype switching to IgE isotypes IEA
Inferred from Electronic Annotation
more info
  
negative regulation of mast cell cytokine production IEA
Inferred from Electronic Annotation
more info
  
negative regulation of mitotic cell cycle DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
 PubMed 
negative regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
 PubMed 
positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
  
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
positive regulation of cellular component movement IEA
Inferred from Electronic Annotation
more info
  
positive regulation of histone deacetylation IEA
Inferred from Electronic Annotation
more info
  
positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
positive regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
protein localization IEA
Inferred from Electronic Annotation
more info
  
regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
regulation of apoptotic process TAS
Traceable Author Statement
more info
  
regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
regulation of germinal center formation NAS
Non-traceable Author Statement
more info
 PubMed 
regulation of immune response NAS
Non-traceable Author Statement
more info
 PubMed 
regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
regulation of memory T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
type 2 immune response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
  
nucleolus IDA
Inferred from Direct Assay
more info
  
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
  
nucleoplasm TAS
Traceable Author Statement
more info
  
nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with replication fork IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
B-cell lymphoma 6 protein
Names
B cell CLL/lymphoma 6
B-cell lymphoma 5 protein
B-cell lymphoma 6 protein transcript
BCL-5
BCL-6
cys-his2 zinc finger transcription factor
lymphoma-associated zinc finger gene on chromosome 3
protein LAZ-3
zinc finger and BTB domain-containing protein 27
zinc finger protein 51
zinc finger transcription factor BCL6S

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007149.1 RefSeqGene

    Range
    5068..29155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130845.2 → NP_001124317.1  B-cell lymphoma 6 protein isoform 1

    See identical proteins and their annotated locations for NP_001124317.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a downstream and alternate 5' UTR exon, as compared to variant 1.
    Source sequence(s)
    AC072022, BC146796, BC150184, CN401512
    Consensus CDS
    CCDS3289.1
    UniProtKB/Swiss-Prot
    P41182
    Related
    ENSP00000232014.4, ENST00000232014.8
    Conserved Domains (4) summary
    smart00225
    Location:33 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 126
    BTB; BTB/POZ domain
    pfam13465
    Location:588 → 613
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001134738.1 → NP_001128210.1  B-cell lymphoma 6 protein isoform 2

    See identical proteins and their annotated locations for NP_001128210.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a coding exon, as compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, as compared to isoform 2.
    Source sequence(s)
    AW337942, BC146796, BC150184, EU883531, Z21943
    Consensus CDS
    CCDS46975.1
    UniProtKB/Swiss-Prot
    P41182
    UniProtKB/TrEMBL
    B5B0A5
    Related
    ENSP00000413122.2, ENST00000450123.6
    Conserved Domains (5) summary
    smart00225
    Location:33 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:520 → 540
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:518 → 540
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:22 → 126
    BTB; BTB/POZ domain
    pfam13465
    Location:532 → 557
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001706.5 → NP_001697.2  B-cell lymphoma 6 protein isoform 1

    See identical proteins and their annotated locations for NP_001697.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
    Source sequence(s)
    BC146796, BC150184, DB079847
    Consensus CDS
    CCDS3289.1
    UniProtKB/Swiss-Prot
    P41182
    Related
    ENSP00000384371.2, ENST00000406870.7
    Conserved Domains (4) summary
    smart00225
    Location:33 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 126
    BTB; BTB/POZ domain
    pfam13465
    Location:588 → 613
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    187721377..187745472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513062.3 → XP_011511364.1  B-cell lymphoma 6 protein isoform X2

    See identical proteins and their annotated locations for XP_011511364.1

    UniProtKB/Swiss-Prot
    P41182
    Related
    ENSP00000479784.1, ENST00000621333.4
    Conserved Domains (5) summary
    smart00225
    Location:33 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:520 → 540
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:518 → 540
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:22 → 126
    BTB; BTB/POZ domain
    pfam13465
    Location:532 → 557
    zf-H2C2_2; Zinc-finger double domain

  2. XM_005247694.4 → XP_005247751.1  B-cell lymphoma 6 protein isoform X1

    See identical proteins and their annotated locations for XP_005247751.1

    UniProtKB/Swiss-Prot
    P41182
    Conserved Domains (4) summary
    smart00225
    Location:33 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 126
    BTB; BTB/POZ domain
    pfam13465
    Location:588 → 613
    zf-H2C2_2; Zinc-finger double domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138931.1: Suppressed sequence

    Description
    NM_138931.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41182.1 GenPept UniProtKB/Swiss-Prot:P41182

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