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BCL6 BCL6 transcription repressor [ Homo sapiens (human) ]

Gene ID: 604, updated on 18-May-2023

Summary

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Official Symbol
BCL6provided by HGNC
Official Full Name
BCL6 transcription repressorprovided by HGNC
Primary source
HGNC:HGNC:1001
See related
Ensembl:ENSG00000113916 MIM:109565; AllianceGenome:HGNC:1001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCL5; LAZ3; BCL6A; ZNF51; ZBTB27
Summary
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in fat (RPKM 29.2), bone marrow (RPKM 20.1) and 25 other tissues See more
Orthologs
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Genomic context

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See BCL6 in Genome Data Viewer
Location:
3q27.3
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (187721377..187745468, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (190538887..190562977, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (187439165..187463256, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene somatostatin Neighboring gene hCG1645011-like Neighboring gene receptor transporter protein 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:187455905-187456884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:187458977-187459478 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:187459479-187459978 Neighboring gene uncharacterized LOC122526776 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:187462369-187462894 Neighboring gene uncharacterized LOC105374263 Neighboring gene uncharacterized LOC105374264 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:187580545-187581195

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Clinical course and features of persistent polyclonal B-cell lymphocytosis with BCL-6 amplification during pregnancy. Galitzia A, et al. Eur Rev Med Pharmacol Sci, 2023 Apr. PMID 37140301
  2. Bcl6 drives stem-like memory macrophages differentiation to foster tumor progression. Zhang W, et al. Cell Mol Life Sci, 2022 Dec 21. PMID 36542153, Free PMC Article
  3. BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer. Li K, et al. J Clin Invest, 2022 Nov 15. PMID 36377663, Free PMC Article
  4. BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis. Louwen F, et al. Hum Reprod Update, 2022 Nov 2. PMID 35640966, Free PMC Article
  5. Defective STAT5 Activation and Aberrant Expression of BCL6 in Naive CD4 T Cells Enhances Follicular Th Cell-like Differentiation in Patients with Granulomatosis with Polyangiitis. Kim S, et al. J Immunol, 2022 Feb 15. PMID 35039330

See all (423) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical course and features of persistent polyclonal B-cell lymphocytosis with BCL-6 amplification during pregnancy.
    Title: Clinical course and features of persistent polyclonal B-cell lymphocytosis with BCL-6 amplification during pregnancy.
  2. Bcl6 drives stem-like memory macrophages differentiation to foster tumor progression.
    Title: Bcl6 drives stem-like memory macrophages differentiation to foster tumor progression.
  3. BCL6-SPECC1L: A Novel Fusion Gene in Nasopharyngeal Carcinoma.
    Title: BCL6-SPECC1L: A Novel Fusion Gene in Nasopharyngeal Carcinoma.
  4. BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer.
    Title: BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer.
  5. BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis.
    Title: BCL6, a key oncogene, in the placenta, pre-eclampsia and endometriosis.
  6. A Bcl6 Intronic Element Regulates T Follicular Helper Cell Differentiation.
    Title: A Bcl6 Intronic Element Regulates T Follicular Helper Cell Differentiation.
  7. LncRNA PCED1B-AS1 Upregulation in Hepatocellular Carcinoma and Regulation of the miR-10a/BCL6 Axis to Promote Cell Proliferation.
    Title: LncRNA PCED1B-AS1 Upregulation in Hepatocellular Carcinoma and Regulation of the miR-10a/BCL6 Axis to Promote Cell Proliferation.
  8. High grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangements: unraveling the genetic landscape of a rare aggressive subtype of non-Hodgkin lymphoma.
    Title: High grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangements: unraveling the genetic landscape of a rare aggressive subtype of non-Hodgkin lymphoma.
  9. Expression of BCL6 in paediatric B-cell acute lymphoblastic leukaemia and association with prognosis.
    Title: Expression of BCL6 in paediatric B-cell acute lymphoblastic leukaemia and association with prognosis.
  10. miR-30b-5p inhibits osteoblast differentiation through targeting BCL6.
    Title: miR-30b-5p inhibits osteoblast differentiation through targeting BCL6.
Submit: New GeneRIF Correction See all GeneRIFs (315)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
EBI GWAS Catalog
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
EBI GWAS Catalog
Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population.
EBI GWAS Catalog
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.
EBI GWAS Catalog
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of B-cell CLL/lymphoma 6 (BCL6) in human B cells PubMed
Tat tat HIV-1 Tat upregulates the expression of T-bet, Eomesdermin, Blimp-1, Bcl-6, and Bcl-2 in stimulated but not in unstimulated CD8+T lymphocytes PubMed
tat HIV-1 Tat upregulates the expression of BCL-6 in Kaposi's sarcoma cells and human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables intronic transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in T-helper 2 cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell motility IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in erythrocyte development IEA
Inferred from Electronic Annotation
more info
  
involved_in germinal center formation IEA
Inferred from Electronic Annotation
more info
  
involved_in heterochromatin formation IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in isotype switching to IgE isotypes IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of B cell apoptotic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of T-helper 2 cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of isotype switching to IgE isotypes IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of leukocyte proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mast cell cytokine production IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mitotic cell cycle DNA replication NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of plasma cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in plasma cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of regulatory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in pyramidal neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of germinal center formation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in regulation of memory T cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in type 2 immune response IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in paraspeckles IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with replication fork IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
B-cell lymphoma 6 protein
Names
B cell CLL/lymphoma 6
B-cell lymphoma 5 protein
B-cell lymphoma 6 protein transcript
BCL-5
BCL-6
cys-his2 zinc finger transcription factor
lymphoma-associated zinc finger gene on chromosome 3
protein LAZ-3
zinc finger and BTB domain-containing protein 27
zinc finger protein 51
zinc finger transcription factor BCL6S

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007149.1 RefSeqGene

    Range
    5068..29155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130845.2 → NP_001124317.1  B-cell lymphoma 6 protein isoform 1

    See identical proteins and their annotated locations for NP_001124317.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a downstream and alternate 5' UTR exon, as compared to variant 1.
    Source sequence(s)
    AC072022, BC146796, BC150184, CN401512
    Consensus CDS
    CCDS3289.1
    UniProtKB/Swiss-Prot
    D3DNV5, P41182
    Related
    ENSP00000232014.4, ENST00000232014.8
    Conserved Domains (4) summary
    smart00225
    Location:33 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 126
    BTB; BTB/POZ domain
    pfam13465
    Location:588 → 613
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001134738.1 → NP_001128210.1  B-cell lymphoma 6 protein isoform 2

    See identical proteins and their annotated locations for NP_001128210.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a coding exon, as compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, as compared to isoform 2.
    Source sequence(s)
    AW337942, BC146796, BC150184, EU883531, Z21943
    Consensus CDS
    CCDS46975.1
    UniProtKB/Swiss-Prot
    P41182
    UniProtKB/TrEMBL
    B5B0A5
    Related
    ENSP00000413122.2, ENST00000450123.6
    Conserved Domains (5) summary
    smart00225
    Location:33 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:520 → 540
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:518 → 540
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:22 → 126
    BTB; BTB/POZ domain
    pfam13465
    Location:532 → 557
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001706.5 → NP_001697.2  B-cell lymphoma 6 protein isoform 1

    See identical proteins and their annotated locations for NP_001697.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
    Source sequence(s)
    BC146796, BC150184, DB079847
    Consensus CDS
    CCDS3289.1
    UniProtKB/Swiss-Prot
    D3DNV5, P41182
    Related
    ENSP00000384371.2, ENST00000406870.7
    Conserved Domains (4) summary
    smart00225
    Location:33 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 126
    BTB; BTB/POZ domain
    pfam13465
    Location:588 → 613
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    187721377..187745468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513062.4 → XP_011511364.1  B-cell lymphoma 6 protein isoform X2

    See identical proteins and their annotated locations for XP_011511364.1

    UniProtKB/Swiss-Prot
    P41182
    Related
    ENSP00000479784.1, ENST00000621333.4
    Conserved Domains (5) summary
    smart00225
    Location:33 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:520 → 540
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:518 → 540
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:22 → 126
    BTB; BTB/POZ domain
    pfam13465
    Location:532 → 557
    zf-H2C2_2; Zinc-finger double domain

  2. XM_047448655.1 → XP_047304611.1  B-cell lymphoma 6 protein isoform X1

    UniProtKB/Swiss-Prot
    D3DNV5

  3. XM_005247694.5 → XP_005247751.1  B-cell lymphoma 6 protein isoform X1

    See identical proteins and their annotated locations for XP_005247751.1

    UniProtKB/Swiss-Prot
    D3DNV5, P41182
    Conserved Domains (4) summary
    smart00225
    Location:33 → 126
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22 → 126
    BTB; BTB/POZ domain
    pfam13465
    Location:588 → 613
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    190538887..190562977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054347430.1 → XP_054203405.1  B-cell lymphoma 6 protein isoform X2

  2. XM_054347429.1 → XP_054203404.1  B-cell lymphoma 6 protein isoform X1

  3. XM_054347428.1 → XP_054203403.1  B-cell lymphoma 6 protein isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138931.1: Suppressed sequence

    Description
    NM_138931.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41182.1 GenPept UniProtKB/Swiss-Prot:P41182

Gene LinkOut

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