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Bcl6 B cell leukemia/lymphoma 6 [ Mus musculus (house mouse) ]

Gene ID: 12053, updated on 29-Jan-2023

Summary

Official Symbol
Bcl6provided by MGI
Official Full Name
B cell leukemia/lymphoma 6provided by MGI
Primary source
MGI:MGI:107187
See related
Ensembl:ENSMUSG00000022508 AllianceGenome:MGI:107187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bcl5
Summary
Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Acts upstream of or within several processes, including hemopoiesis; negative regulation of signal transduction; and regulation of lymphocyte activation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in B-cell lymphoma and diffuse large B-cell lymphoma. Orthologous to human BCL6 (BCL6 transcription repressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 22.9), subcutaneous fat pad adult (RPKM 15.7) and 20 other tissues See more
Orthologs
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Genomic context

See Bcl6 in Genome Data Viewer
Location:
16 B1; 16 15.26 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (23783800..23807623, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (23965050..23988866, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene somatostatin Neighboring gene receptor transporter protein 2 Neighboring gene predicted gene, 46545 Neighboring gene predicted gene, 31583

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (14)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables intronic transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Rho protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T-helper 2 cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within erythrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within germinal center formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heterochromatin formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of histone deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of isotype switching to IgE isotypes IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of isotype switching to IgE isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of leukocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mast cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T-helper 2 cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of isotype switching to IgE isotypes IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of isotype switching to IgE isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of leukocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of mast cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of plasma cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of type 2 immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of plasma cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of histone deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of pyramidal neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of memory T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in type 2 immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within type 2 immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in paraspeckles ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with replication fork ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
B-cell lymphoma 6 protein homolog
Names
B-cell leukemia/lymphoma 5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348026.1NP_001334955.1  B-cell lymphoma 6 protein homolog

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC158397
    Consensus CDS
    CCDS28082.1
    UniProtKB/Swiss-Prot
    P41183, Q61065
    UniProtKB/TrEMBL
    Q544F9
    Conserved Domains (4) summary
    PHA03247
    Location:179429
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:577597
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18331
    Location:8125
    BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)
    pfam13465
    Location:589614
    zf-H2C2_2; Zinc-finger double domain
  2. NM_009744.4NP_033874.1  B-cell lymphoma 6 protein homolog

    See identical proteins and their annotated locations for NP_033874.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC158397, AK151229
    Consensus CDS
    CCDS28082.1
    UniProtKB/Swiss-Prot
    P41183, Q61065
    UniProtKB/TrEMBL
    Q544F9
    Related
    ENSMUSP00000023151.6, ENSMUST00000023151.6
    Conserved Domains (4) summary
    PHA03247
    Location:179429
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:577597
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18331
    Location:8125
    BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)
    pfam13465
    Location:589614
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    23783800..23807623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248941.2XP_030104801.1  B-cell lymphoma 6 protein homolog isoform X1

    UniProtKB/Swiss-Prot
    Q61065
    UniProtKB/TrEMBL
    Q544F9
    Conserved Domains (4) summary
    PHA03247
    Location:179429
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:577597
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18331
    Location:8125
    BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)
    pfam13465
    Location:589614
    zf-H2C2_2; Zinc-finger double domain