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CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 [ Homo sapiens (human) ]

Gene ID: 59283, updated on 11-Jun-2021

Summary

Official Symbol
CACNG8provided by HGNC
Official Full Name
calcium voltage-gated channel auxiliary subunit gamma 8provided by HGNC
Primary source
HGNC:HGNC:13628
See related
Ensembl:ENSG00000142408 MIM:606900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. The mRNA for this gene is believed to initiate translation from a non-AUG (CUG) start codon. [provided by RefSeq, Dec 2010]
Expression
Restricted expression toward brain (RPKM 9.1) See more
Orthologs
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Genomic context

See CACNG8 in Genome Data Viewer
Location:
19q13.42
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (53962937..53990215)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (54466191..54493469)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene protein kinase C gamma Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 7 Neighboring gene microRNA 935 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 6 Neighboring gene V-set and transmembrane domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16240, FLJ30598

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables voltage-gated calcium channel activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of L-type voltage-gated calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of voltage-gated calcium channel complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
voltage-dependent calcium channel gamma-8 subunit
Names
TARP gamma-8
calcium channel, voltage-dependent, gamma subunit 8
neuronal voltage-gated calcium channel gamma-8 subunit
transmembrane AMPAR regulatory protein gamma-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031895.6NP_114101.4  voltage-dependent calcium channel gamma-8 subunit

    See identical proteins and their annotated locations for NP_114101.4

    Status: REVIEWED

    Source sequence(s)
    AC008440, AF288388
    Consensus CDS
    CCDS33104.1
    UniProtKB/Swiss-Prot
    Q8WXS5
    Related
    ENSP00000270458.3, ENST00000270458.4
    Conserved Domains (1) summary
    cl21598
    Location:17223
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    53962937..53990215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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