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Cacng8 calcium channel, voltage-dependent, gamma subunit 8 [ Mus musculus (house mouse) ]

Gene ID: 81905, updated on 12-May-2024

Summary

Official Symbol
Cacng8provided by MGI
Official Full Name
calcium channel, voltage-dependent, gamma subunit 8provided by MGI
Primary source
MGI:MGI:1932376
See related
Ensembl:ENSMUSG00000053395 AllianceGenome:MGI:1932376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables calcium channel regulator activity. Involved in regulation of AMPA receptor activity and regulation of postsynaptic membrane neurotransmitter receptor levels. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Is integral component of postsynaptic density membrane. Part of L-type voltage-gated calcium channel complex. Is expressed in central nervous system and retina. Orthologous to human CACNG8 (calcium voltage-gated channel auxiliary subunit gamma 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 16.4), cortex adult (RPKM 14.4) and 10 other tissues See more
Orthologs
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Genomic context

See Cacng8 in Genome Data Viewer
Location:
7 A1; 7 1.98 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3442558..3464782)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3394042..3416266)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17899 Neighboring gene calcium channel, voltage-dependent, gamma subunit 7 Neighboring gene STARR-seq mESC enhancer starr_17900 Neighboring gene predicted gene 9567 Neighboring gene RIKEN cDNA 3300002P13 gene Neighboring gene microRNA 935 Neighboring gene STARR-seq mESC enhancer starr_17905 Neighboring gene calcium channel, voltage-dependent, gamma subunit 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase 2B binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in neurotransmitter receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of AMPA receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of AMPA receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of AMPA receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
Inferred from Direct Assay
more info
 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
Inferred from Mutant Phenotype
more info
 
involved_in transmission of nerve impulse IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of L-type voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
voltage-dependent calcium channel gamma-8 subunit
Names
TARP gamma-8
neuronal voltage-gated calcium channel gamma-8 subunit
transmembrane AMPAR regulatory protein gamma-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133190.3NP_573453.2  voltage-dependent calcium channel gamma-8 subunit

    Status: VALIDATED

    Source sequence(s)
    AC217111
    Consensus CDS
    CCDS57471.1
    UniProtKB/Swiss-Prot
    Q8VHW2
    UniProtKB/TrEMBL
    F7CZ64, S4R2F1
    Related
    ENSMUSP00000090005.6, ENSMUST00000092351.6
    Conserved Domains (1) summary
    cl21598
    Location:17222
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3442558..3464782
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)