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CYP20A1 cytochrome P450 family 20 subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 57404, updated on 1-Aug-2020

Summary

Official Symbol
CYP20A1provided by HGNC
Official Full Name
cytochrome P450 family 20 subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:20576
See related
Ensembl:ENSG00000119004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYP-M
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein lacks one amino acid of the conserved heme binding site. It also lacks the conserved I-helix motif AGX(D,E)T, suggesting that its substrate may carry its own oxygen. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 2.4), kidney (RPKM 1.7) and 25 other tissues See more
Orthologs

Genomic context

See CYP20A1 in Genome Data Viewer
Location:
2q33.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (203238982..203306026)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (204103164..204170563)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene neurobeachin like 1 Neighboring gene ribosomal protein L23a pseudogene 36 Neighboring gene ribosomal protein L12 pseudogene 16 Neighboring gene RNA, 7SL, cytoplasmic 670, pseudogene Neighboring gene mitochondrial ribosomal protein L50 pseudogene 2 Neighboring gene abl interactor 2 Neighboring gene tRNA-Glu (anticodon TTC) 9-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22229

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
cytochrome P450 20A1
Names
cytochrome P450 monooxygenase
cytochrome P450, family 20, subfamily A, polypeptide 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007956.1 RefSeqGene

    Range
    5578..72586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001371695.1NP_001358624.1  cytochrome P450 20A1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
    Related
    ENSP00000407860.2, ENST00000429815.6
  2. NM_001371696.1NP_001358625.1  cytochrome P450 20A1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  3. NM_001371697.1NP_001358626.1  cytochrome P450 20A1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  4. NM_001371698.1NP_001358627.1  cytochrome P450 20A1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  5. NM_001371699.1NP_001358628.1  cytochrome P450 20A1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  6. NM_001371700.1NP_001358629.1  cytochrome P450 20A1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  7. NM_001371701.1NP_001358630.1  cytochrome P450 20A1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  8. NM_001371702.1NP_001358631.1  cytochrome P450 20A1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  9. NM_001371703.1NP_001358632.1  cytochrome P450 20A1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  10. NM_001371704.1NP_001358633.1  cytochrome P450 20A1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  11. NM_001371705.1NP_001358634.1  cytochrome P450 20A1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  12. NM_001371706.1NP_001358635.1  cytochrome P450 20A1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
    Related
    ENSP00000482757.1, ENST00000613925.4
  13. NM_177538.3NP_803882.1  cytochrome P450 20A1 isoform 2

    See identical proteins and their annotated locations for NP_803882.1

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
    Consensus CDS
    CCDS2357.1
    UniProtKB/Swiss-Prot
    Q6UW02
    Related
    ENSP00000348380.4, ENST00000356079.9
    Conserved Domains (1) summary
    cl12078
    Location:43446
    p450; Cytochrome P450

RNA

  1. NR_163981.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  2. NR_163982.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  3. NR_163983.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  4. NR_163984.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075
  5. NR_163985.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011737, AC080075

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    203238982..203306026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712645.3XP_006712708.1  cytochrome P450 20A1 isoform X2

    Conserved Domains (1) summary
    cl12078
    Location:221381
    p450; Cytochrome P450
  2. XM_006712644.4XP_006712707.1  cytochrome P450 20A1 isoform X1

    Conserved Domains (1) summary
    cl12078
    Location:25428
    p450; Cytochrome P450

RNA

  1. XR_001738857.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_020674.2: Suppressed sequence

    Description
    NM_020674.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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