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ZC3HAV1 zinc finger CCCH-type containing, antiviral 1 [ Homo sapiens (human) ]

Gene ID: 56829, updated on 7-Jun-2020

Summary

Official Symbol
ZC3HAV1provided by HGNC
Official Full Name
zinc finger CCCH-type containing, antiviral 1provided by HGNC
Primary source
HGNC:HGNC:23721
See related
Ensembl:ENSG00000105939 MIM:607312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAP; ZC3H2; ARTD13; PARP13; FLB6421; ZC3HDC2
Summary
This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 17.0), lymph node (RPKM 9.0) and 24 other tissues See more
Orthologs

Genomic context

See ZC3HAV1 in Genome Data Viewer
Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (139043515..139109720, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (138728266..138794466, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene KIAA1549 Neighboring gene RNA, U6 small nuclear 1272, pseudogene Neighboring gene uncharacterized LOC107986852 Neighboring gene zinc finger CCCH-type containing, antiviral 1 like Neighboring gene microRNA 10399 Neighboring gene ribosomal protein L17 pseudogene 28 Neighboring gene Sharpr-MPRA regulatory region 8039 Neighboring gene tetratricopeptide repeat domain 26 Neighboring gene MSL complex subunit 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ZC3HAV1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated zinc finger CCCH-type, antiviral 1 (ZC3HAV1) protein is incorporated into HIV-1 Gag virus-like particles PubMed
gag Interaction of HIV-1 Gag with zinc finger CCCH-type, antiviral 1 (ZC3HAV1) is identified in a series of six affinity purification/mass spectrometry screens PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human zinc finger CCCH-type, antiviral 1 (ZC3HAV1) at amino acid residues 260-261 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13288, MGC48898, DKFZp686F2052, DKFZp686H1869, DKFZp686O19171

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT NAD+ ADP-ribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT NAD+ binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
NOT protein ADP-ribosylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein poly-ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger CCCH-type antiviral protein 1
Names
ADP-ribosyltransferase diphtheria toxin-like 13
inactive Poly [ADP-ribose] polymerase 13
zinc finger CCCH domain-containing protein 2
zinc finger CCCH-type, antiviral 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029457.1 RefSeqGene

    Range
    5000..71205
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001363491.2NP_001350420.1  zinc finger CCCH-type antiviral protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC018644, AC083868, AI133088, BC040956, BU634030, BX571742, BX647974
    Related
    ENSP00000418385.1, ENST00000464606.5
    Conserved Domains (2) summary
    smart00678
    Location:729811
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:9061015
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
  2. NM_020119.4NP_064504.2  zinc finger CCCH-type antiviral protein 1 isoform 1

    See identical proteins and their annotated locations for NP_064504.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant encodes isoform 1.
    Source sequence(s)
    AC018644, AC083868, BC040956, BX571742, BX647974
    Consensus CDS
    CCDS5851.1
    UniProtKB/Swiss-Prot
    Q7Z2W4
    Related
    ENSP00000242351.5, ENST00000242351.10
    Conserved Domains (3) summary
    smart00678
    Location:607689
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd01439
    Location:784893
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam00644
    Location:727893
    PARP; Poly(ADP-ribose) polymerase catalytic domain
  3. NM_024625.4NP_078901.3  zinc finger CCCH-type antiviral protein 1 isoform 2

    See identical proteins and their annotated locations for NP_078901.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and lacks several downstream exons, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC018644
    Consensus CDS
    CCDS55171.1
    UniProtKB/Swiss-Prot
    Q7Z2W4
    Related
    ENSP00000419855.1, ENST00000471652.1
    Conserved Domains (1) summary
    smart00678
    Location:607689
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    139043515..139109720 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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