Conserved Protein Domain Family
TCCD_inducible_PARP_like

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cd01439: TCCD_inducible_PARP_like 
Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes pleotropic effects in mammalian species through modulating gene expression. TCCD indicible PARP (TiPARP) is a target of TCDD that may contribute to multiple responses to TCDD by modulating protein function through poly ADP-ribosylation
Statistics
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PSSM-Id: 238719
View PSSM: cd01439
Aligned: 17 rows
Threshold Bit Score: 126.665
Threshold Setting Gi: 38640064
Created: 12-Dec-2003
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
nad+ binding
Feature 1:nad+ binding pocket [chemical binding site]
Evidence:None

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #####  #   #     ### #            ###         #                               
gi 38524594  529 HLFHGTSQDVVDGICKh--NFDPRVcgkhatmFGQGSYFAKKASYSHNFSkkssk--gvhfMFLAKVLTGRYTMGshgmr 604
gi 47117630  561 QLFHGTSAIFVDAICQq--NFDWRVcgvhgtsYGKGSYFARDAAYSHHYSksdt---qthtMFLARVLVGEFVRGnasfv 635
gi 47225805  570 YLFHGTDESLVEAICEq--NFDWRVcgthgtvYGKGSYFAKDASYSDQYSrissr--rnkiMFVALVLVGDSTQGrssyv 645
gi 47218268  731 KLFHGTDNQYVDTICHt--NFDWRLcgshgtaFGKGYYFAQNAKYSHSYTsdsn----vrsMFVVRLLVGEYTKGspeyr 804
gi 20270913  153 LLFHGTSSDSITQINNh--GFNRSYagthgaaIGNGSYFAVNSSYSARGYskada-qgnkrMYLARVLVGDYTQGqagli 229
gi 21757820  322 LLFHGTDADSVPYVNQh--GFNRSCagknavsYGKGTYFAVDASYSAKDTyskpdsngrkhMYVVRVLTGVFTKGraglv 399
gi 47217767   32 TLYHGTSEESMKEICLh--GFNRSFcgknatvYGQGVYFAVNSAVSLNDRysppnadghkfVFVSRVLTGDYTKGcssmk 109
gi 42734056 1480 YLFHGTSATQPESIYNsknCFDWRFske-scmWGNGSYFAYNASYSHRYSyktpq--klnqIFIATVLIGDSITSepdss 1556
gi 42658781  884 VLYHGTTAPAVPDICAh--GFNRSFcgrnatvYGKGVYFARRASLSVQDRysppnadghkaVFVARVLTGDYGQGrrglr 961
gi 13899297  702 RLFQQVPYQFCNVVCRv--GFQRMYstpcdpkYGAGIYFTKNLKNLAEKAkkisaadkliyVFEAEVLTGFFCQGhplni 779
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
Feature 1                                   #                    
gi 38524594  605 rppp-vnpgsvtsDLYDSCVDnffEPQIFVIFnd---dQSYPYFVIQY 648
gi 47117630  636 rpp---akegwsnAFYDSCVNsvsDPSIFVIFek---hQVYPEYVIQY 677
gi 47225805  646 rp----ppkgnskAFYDSCVNsesNPSIYVIFek---qQIYPEYLINY 686
gi 47218268  805 rpp---skdggdiNFYDSCVDdvhTPSIYVVFdk---hQIYPEYLLQY 846
gi 20270913  230 vpp--akpsgkdaDLYDSVTDntsNPTMFVIFsd---vQAYPEFLIHS 272
gi 21757820  400 tpp--pknphnptDLFDSVTNntrSPKLFVVFfd---nQAYPEYLITF 442
gi 47217767  110 aap--lkpgsdvpFRYDSVTNnmdNPKIFVIFsd---tQAFPQYLITC 152
gi 42734056 1557 lklpplkdstnknVRYDSVKG---NPLGSDIYivydnqQSYPYYLVTY 1601
gi 42658781  962 app--lrgpghvlLRYDSAVDcicQPSIFVIFhd---tQALPTHLITC 1004
gi 13899297  780 vpp---plspgaiDGHDSVVDnvsSPETFVIFsg---mQAIPQYLWTC 821

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