U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zc3hav1 zinc finger CCCH type, antiviral 1 [ Mus musculus (house mouse) ]

Gene ID: 78781, updated on 12-May-2024

Summary

Official Symbol
Zc3hav1provided by MGI
Official Full Name
zinc finger CCCH type, antiviral 1provided by MGI
Primary source
MGI:MGI:1926031
See related
Ensembl:ENSMUSG00000029826 AllianceGenome:MGI:1926031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZAP; ARTD13; PARP13; D6Bwg1452e; 1200014N16Rik; 2900058M19Rik; 9130009D18Rik; 9830115L13Rik
Summary
Predicted to enable DEAD/H-box RNA helicase binding activity; RNA binding activity; and identical protein binding activity. Acts upstream of or within cellular response to exogenous dsRNA and positive regulation of type I interferon production. Located in late endosome; lysosome; and nucleus. Is expressed in early conceptus; inner cell mass; liver lobe; oocyte; and thymus primordium. Orthologous to human ZC3HAV1 (zinc finger CCCH-type containing, antiviral 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 12.8), spleen adult (RPKM 10.0) and 21 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Zc3hav1 in Genome Data Viewer
Location:
6 B1; 6 17.72 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (38282221..38332859, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (38305286..38355352, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15615 Neighboring gene predicted gene 7504 Neighboring gene zinc finger CCCH-type, antiviral 1-like Neighboring gene predicted gene, 53283 Neighboring gene STARR-seq mESC enhancer starr_15617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:38292594-38292777 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:38304490-38304693 Neighboring gene STARR-seq mESC enhancer starr_15619 Neighboring gene STARR-seq mESC enhancer starr_15622 Neighboring gene UPF0547 protein C16orf87 homolog Neighboring gene ribosomal protein L30, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DEAD/H-box RNA helicase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables NAD+ ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of ATP-dependent activity ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of RIG-I signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon production IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
zinc finger CCCH-type antiviral protein 1
Names
ADP-ribosyltransferase diphtheria toxin-like 13
inactive Poly [ADP-ribose] polymerase 13

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347122.1NP_001334051.1  zinc finger CCCH-type antiviral protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
    Source sequence(s)
    AC125530
    Consensus CDS
    CCDS85033.1
    UniProtKB/TrEMBL
    D3Z5I1
    Related
    ENSMUSP00000110550.2, ENSMUST00000114900.8
  2. NM_028421.1NP_082697.1  zinc finger CCCH-type antiviral protein 1 isoform 1

    See identical proteins and their annotated locations for NP_082697.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform 1 which is shorter and has a distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AC125530
    Consensus CDS
    CCDS80522.1
    UniProtKB/Swiss-Prot
    Q3UPF5, Q9CTU4, Q9DBS7
    Related
    ENSMUSP00000144312.2, ENSMUST00000143702.5
    Conserved Domains (2) summary
    pfam02825
    Location:696772
    WWE; WWE domain
    cl00283
    Location:876908
    ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...
  3. NM_028864.2NP_083140.1  zinc finger CCCH-type antiviral protein 1 isoform 2

    See identical proteins and their annotated locations for NP_083140.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    AK004770
    Consensus CDS
    CCDS20012.1
    UniProtKB/TrEMBL
    G3X9X5
    Related
    ENSMUSP00000031850.5, ENSMUST00000031850.10
    Conserved Domains (1) summary
    pfam02825
    Location:696772
    WWE; WWE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    38282221..38332859 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506780.5XP_006506843.1  zinc finger CCCH-type antiviral protein 1 isoform X1

    Conserved Domains (4) summary
    cd01439
    Location:760868
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    pfam02825
    Location:581656
    WWE; WWE domain
    pfam18606
    Location:566
    HTH_53; Zap helix turn helix N-terminal domain
    pfam18633
    Location:143170
    zf-CCCH_8; Zinc-finger antiviral protein (ZAP) zinc finger domain 3