Format

Send to:

Choose Destination

SAR1A secretion associated Ras related GTPase 1A [ Homo sapiens (human) ]

Gene ID: 56681, updated on 24-Nov-2020

Summary

Official Symbol
SAR1Aprovided by HGNC
Official Full Name
secretion associated Ras related GTPase 1Aprovided by HGNC
Primary source
HGNC:HGNC:10534
See related
Ensembl:ENSG00000079332 MIM:607691
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAR1; Sara; SARA1; masra2
Expression
Ubiquitous expression in fat (RPKM 47.2), placenta (RPKM 41.9) and 25 other tissues See more
Orthologs

Genomic context

See SAR1A in Genome Data Viewer
Location:
10q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (70147289..70170514, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71909960..71930285, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene macroH2A.2 histone Neighboring gene apoptosis inducing factor mitochondria associated 2 Neighboring gene trypsin like peroxisomal matrix peptidase 1 Neighboring gene calmodulin 2 pseudogene 2 Neighboring gene ribosomal protein S25 pseudogene 9 Neighboring gene inorganic pyrophosphatase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with SAR1A; predicted interaction to be within the endoplasmic reticulum to Golgi transport PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COPII-coated vesicle cargo loading IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein exit from endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of COPII vesicle coating IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COPII vesicle coat IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GTP-binding protein SAR1a
Names
COPII-associated small GTPase
SAR1 gene homolog A
SAR1 homolog A
SAR1a gene homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142648.2NP_001136120.1  GTP-binding protein SAR1a

    See identical proteins and their annotated locations for NP_001136120.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL731540, AW128933, BC003658, BG327663, DB216796, DR763562, EB388518
    Consensus CDS
    CCDS7298.1
    UniProtKB/Swiss-Prot
    Q9NR31
    UniProtKB/TrEMBL
    Q5SQT9
    Related
    ENSP00000362339.1, ENST00000373242.6
    Conserved Domains (1) summary
    cd00879
    Location:3197
    Sar1; Sar1 is an essential component of COPII vesicle coats
  2. NM_020150.5NP_064535.1  GTP-binding protein SAR1a

    See identical proteins and their annotated locations for NP_064535.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL731540, AW128933, BC003658, DB216796, DR763562, EB388518
    Consensus CDS
    CCDS7298.1
    UniProtKB/Swiss-Prot
    Q9NR31
    UniProtKB/TrEMBL
    Q5SQT9
    Related
    ENSP00000362338.4, ENST00000373241.9
    Conserved Domains (1) summary
    cd00879
    Location:3197
    Sar1; Sar1 is an essential component of COPII vesicle coats

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    70147289..70170514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center