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Sar1a secretion associated Ras related GTPase 1A [ Mus musculus (house mouse) ]

Gene ID: 20224, updated on 2-Nov-2024

Summary

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Official Symbol
Sar1aprovided by MGI
Official Full Name
secretion associated Ras related GTPase 1Aprovided by MGI
Primary source
MGI:MGI:98230
See related
Ensembl:ENSMUSG00000020088 AllianceGenome:MGI:98230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sara; Sara1; 1600019H17Rik
Summary
Predicted to enable G protein activity and amino acid sensor activity. Acts upstream of or within negative regulation of cargo loading into COPII-coated vesicle and vesicle-mediated transport. Located in Golgi apparatus and sarcoplasmic reticulum. Is expressed in several structures, including genitourinary system; liver; nervous system; retina nuclear layer; and skeletal musculature. Orthologous to human SAR1A (secretion associated Ras related GTPase 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 41.8), bladder adult (RPKM 39.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Sar1a in Genome Data Viewer
Location:
10 B4; 10 32.26 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (61516096..61529076)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (61680285..61693297)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10613 Neighboring gene STARR-positive B cell enhancer ABC_E6861 Neighboring gene pyrophosphatase (inorganic) 1 Neighboring gene RIKEN cDNA 1700022H01 gene Neighboring gene STARR-positive B cell enhancer ABC_E9032 Neighboring gene STARR-positive B cell enhancer ABC_E1800 Neighboring gene trypsin domain containing 1 Neighboring gene apoptosis-inducing factor, mitochondrion-associated 2 Neighboring gene STARR-seq mESC enhancer starr_26853 Neighboring gene macroH2A.2 histone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular analysis of SAR1-related cDNAs from a mouse pituitary cell line. Shen KA, et al. FEBS Lett, 1993 Dec 13. PMID 8262187
  2. The FYVE domain of Smad Anchor for Receptor Activation (SARA) is required to prevent skin carcinogenesis, but not in mouse development. Chang HM, et al. PLoS One, 2014. PMID 25170969, Free PMC Article
  3. Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo. Tang VT, et al. Proc Natl Acad Sci U S A, 2024 May 7. PMID 38687799, Free PMC Article
  4. Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset. Mansur A, et al. Elife, 2023 Jul 11. PMID 37432316, Free PMC Article
  5. Vesicle budding from endoplasmic reticulum is involved in calsequestrin routing to sarcoplasmic reticulum of skeletal muscles. Nori A, et al. Biochem J, 2004 Apr 15. PMID 14728599, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.
    Title: Functional overlap between the mammalian Sar1a and Sar1b paralogs in vivo.
  2. Smad anchor for receptor activation nuclear localization during development identifies Layers V and VI of the neocortex.
    Title: Smad anchor for receptor activation nuclear localization during development identifies Layers V and VI of the neocortex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amino acid sensor activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in COPII vesicle coating ISO
Inferred from Sequence Orthology
more info
  
involved_in COPII vesicle coating ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in COPII-coated vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
  
involved_in COPII-coated vesicle cargo loading ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to leucine starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cargo loading into COPII-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of COPII vesicle coating IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cargo loading into COPII-coated vesicle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPII vesicle coat ISO
Inferred from Sequence Orthology
more info
  
part_of COPII vesicle coat ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum exit site ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small COPII coat GTPase SAR1A; GTP-binding protein SAR1a
Names
SAR1 gene homolog A
SAR1a gene homolog 1
NP_001345416.1
NP_001345417.1
NP_001393258.1
NP_001393259.1
NP_001393260.1
NP_001393261.1
NP_001393262.1
NP_001393263.1
NP_001393264.1
NP_001393265.1
NP_001393266.1
NP_001393267.1
NP_001393268.1
NP_001393269.1
NP_033146.1
XP_006513464.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358487.2 → NP_001345416.1  small COPII coat GTPase SAR1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124421
    Consensus CDS
    CCDS23883.1
    UniProtKB/TrEMBL
    Q3TXJ4, Q99JZ4
    Conserved Domains (1) summary
    cd00879
    Location:3 → 197
    Sar1; Sar1 is an essential component of COPII vesicle coats

  2. NM_001358488.2 → NP_001345417.1  small COPII coat GTPase SAR1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124421
    Consensus CDS
    CCDS23883.1
    UniProtKB/TrEMBL
    Q3TXJ4, Q99JZ4
    Conserved Domains (1) summary
    cd00879
    Location:3 → 197
    Sar1; Sar1 is an essential component of COPII vesicle coats

  3. NM_001406329.1 → NP_001393258.1  small COPII coat GTPase SAR1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124421
    UniProtKB/TrEMBL
    Q99JZ4

  4. NM_001406330.1 → NP_001393259.1  small COPII coat GTPase SAR1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124421
    UniProtKB/TrEMBL
    Q99JZ4

  5. NM_001406331.1 → NP_001393260.1  small COPII coat GTPase SAR1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124421
    UniProtKB/TrEMBL
    Q99JZ4
    Related
    ENSMUSP00000151383.2, ENSMUST00000219506.2

  6. NM_001406332.1 → NP_001393261.1  small COPII coat GTPase SAR1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124421
    UniProtKB/TrEMBL
    Q99JZ4

  7. NM_001406333.1 → NP_001393262.1  small COPII coat GTPase SAR1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124421
    UniProtKB/TrEMBL
    Q99JZ4

  8. NM_001406334.1 → NP_001393263.1  small COPII coat GTPase SAR1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124421
    UniProtKB/TrEMBL
    Q99JZ4

  9. NM_001406335.1 → NP_001393264.1  small COPII coat GTPase SAR1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124421
    UniProtKB/TrEMBL
    Q99JZ4

  10. NM_001406336.1 → NP_001393265.1  small COPII coat GTPase SAR1A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124421
    UniProtKB/TrEMBL
    Q99JZ4

  11. NM_001406337.1 → NP_001393266.1  small COPII coat GTPase SAR1A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124421

  12. NM_001406338.1 → NP_001393267.1  small COPII coat GTPase SAR1A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124421

  13. NM_001406339.1 → NP_001393268.1  small COPII coat GTPase SAR1A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124421

  14. NM_001406340.1 → NP_001393269.1  small COPII coat GTPase SAR1A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124421

  15. NM_009120.4 → NP_033146.1  small COPII coat GTPase SAR1A isoform 1

    See identical proteins and their annotated locations for NP_033146.1

    Status: VALIDATED

    Source sequence(s)
    AC124421
    Consensus CDS
    CCDS23883.1
    UniProtKB/TrEMBL
    Q3TXJ4, Q99JZ4
    Related
    ENSMUSP00000020285.9, ENSMUST00000020285.10
    Conserved Domains (1) summary
    cd00879
    Location:3 → 197
    Sar1; Sar1 is an essential component of COPII vesicle coats

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    61516096..61529076
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513401.4 → XP_006513464.1  GTP-binding protein SAR1a isoform X1

    See identical proteins and their annotated locations for XP_006513464.1

    UniProtKB/TrEMBL
    Q3TXJ4, Q99JZ4
    Conserved Domains (1) summary
    cd00879
    Location:3 → 197
    Sar1; Sar1 is an essential component of COPII vesicle coats
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36536.1 GenPept UniProtKB/Swiss-Prot:P36536

Gene LinkOut

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