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AIFM2 apoptosis inducing factor mitochondria associated 2 [ Homo sapiens (human) ]

Gene ID: 84883, updated on 2-Mar-2021

Summary

Official Symbol
AIFM2provided by HGNC
Official Full Name
apoptosis inducing factor mitochondria associated 2provided by HGNC
Primary source
HGNC:HGNC:21411
See related
Ensembl:ENSG00000042286 MIM:605159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMID; FSP1; PRG3
Summary
This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]
Expression
Broad expression in fat (RPKM 26.6), thyroid (RPKM 7.3) and 22 other tissues See more
Orthologs
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Genomic context

See AIFM2 in Genome Data Viewer
Location:
10q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (70112271..70132825, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71872027..71892581, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2636 Neighboring gene macroH2A.2 histone Neighboring gene HNF4 motif-containing MPRA enhancer 70 Neighboring gene trypsin like peroxisomal matrix peptidase 1 Neighboring gene secretion associated Ras related GTPase 1A Neighboring gene calmodulin 2 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686L1298

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
electron-transferring-flavoprotein dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
electron-transferring-flavoprotein dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic mitochondrial changes IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic mitochondrial changes IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ferroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
respiratory electron transport chain IEA
Inferred from Electronic Annotation
more info
 
ubiquinone metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ferroptosis suppressor protein 1
Names
apoptosis-inducing factor (AIF)-like mitochondrion-associated inducer of death
apoptosis-inducing factor 2
apoptosis-inducing factor, mitochondrion-associated, 2
p53-responsive gene 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198696.2NP_001185625.1  ferroptosis suppressor protein 1

    See identical proteins and their annotated locations for NP_001185625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI922797, AL731540, BC023601, BP331371
    Consensus CDS
    CCDS7297.1
    UniProtKB/Swiss-Prot
    Q9BRQ8
    Related
    ENSP00000478931.1, ENST00000613322.4
    Conserved Domains (1) summary
    cl26176
    Location:39356
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]
  2. NM_032797.6NP_116186.1  ferroptosis suppressor protein 1

    See identical proteins and their annotated locations for NP_116186.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI922797, AL731540, BC023601, BG332787
    Consensus CDS
    CCDS7297.1
    UniProtKB/Swiss-Prot
    Q9BRQ8
    Related
    ENSP00000312370.1, ENST00000307864.3
    Conserved Domains (1) summary
    cl26176
    Location:39356
    NirB; NAD(P)H-nitrite reductase, large subunit [Energy production and conversion]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    70112271..70132825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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