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PKN2 protein kinase N2 [ Homo sapiens (human) ]

Gene ID: 5586, updated on 9-Oct-2021

Summary

Official Symbol
PKN2provided by HGNC
Official Full Name
protein kinase N2provided by HGNC
Primary source
HGNC:HGNC:9406
See related
Ensembl:ENSG00000065243 MIM:602549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAK2; PRK2; STK7; Pak-2; PRKCL2; PRO2042
Expression
Ubiquitous expression in ovary (RPKM 11.1), duodenum (RPKM 10.9) and 25 other tissues See more
Orthologs
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Genomic context

See PKN2 in Genome Data Viewer
Location:
1p22.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (88684239..88836255)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89149956..89301938)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PKN2 antisense RNA 1 Neighboring gene ribosomal protein L36a pseudogene 10 Neighboring gene uncharacterized LOC105378838 Neighboring gene Sharpr-MPRA regulatory region 5313 Neighboring gene Sharpr-MPRA regulatory region 874 Neighboring gene RNA, U6 small nuclear 125, pseudogene Neighboring gene elongin C pseudogene 19 Neighboring gene general transcription factor IIB Neighboring gene shieldin complex subunit 1 pseudogene Neighboring gene kynurenine aminotransferase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
GeneReviews: Not available
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
GeneReviews: Not available
Genome-wide association study of periodontal pathogen colonization.
GeneReviews: Not available
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein kinase N2 (PKN2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with PKN2 PubMed
Vpu vpu In vitro protein-protein interaction analysis identifies a Vpu-binding host protein protein kinase N2 (PKN2) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC71074, MGC150606

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding HDA PubMed 
enables RNA polymerase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cadherin binding HDA PubMed 
enables calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apical junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of viral genome replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in apical junction complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase N2
Names
PKN gamma
cardiolipin-activated protein kinase Pak2
protein kinase C-like 2
protein-kinase C-related kinase 2
NP_001307636.1
NP_001307637.1
NP_001307638.1
NP_006247.1
XP_011540074.1
XP_016857271.1
XP_016857272.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320707.2NP_001307636.1  serine/threonine-protein kinase N2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC119426, AK300304, AL136381, BC125199
    Consensus CDS
    CCDS81350.1
    UniProtKB/Swiss-Prot
    Q16513
    Related
    ENSP00000359544.5, ENST00000370513.9
    Conserved Domains (6) summary
    cd11622
    Location:42107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11635
    Location:209282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    smart00220
    Location:614868
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:609934
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:130201
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    cl14603
    Location:390472
    C2; C2 domain
  2. NM_001320708.2NP_001307637.1  serine/threonine-protein kinase N2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC119426, AK298595, AL136381, BC125199
    UniProtKB/Swiss-Prot
    Q16513
    Conserved Domains (5) summary
    cd08687
    Location:233316
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11635
    Location:52125
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    smart00220
    Location:505759
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:500825
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:144
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  3. NM_001320709.2NP_001307638.1  serine/threonine-protein kinase N2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AC119426, AK298595, AK300304, AL136381
    UniProtKB/Swiss-Prot
    Q16513
    Conserved Domains (6) summary
    cd08687
    Location:364457
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:42107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11635
    Location:209282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    smart00220
    Location:646900
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:641966
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:130201
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  4. NM_006256.4NP_006247.1  serine/threonine-protein kinase N2 isoform 1

    See identical proteins and their annotated locations for NP_006247.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC119426, AL136381, U33052
    Consensus CDS
    CCDS714.1
    UniProtKB/Swiss-Prot
    Q16513
    Related
    ENSP00000359552.3, ENST00000370521.8
    Conserved Domains (5) summary
    cd08687
    Location:390473
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:42107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11635
    Location:209282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd05589
    Location:657982
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
    cl00087
    Location:130201
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    88684239..88836255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001783.2XP_016857272.1  serine/threonine-protein kinase N2 isoform X2

  2. XM_017001782.2XP_016857271.1  serine/threonine-protein kinase N2 isoform X1

  3. XM_011541772.2XP_011540074.1  serine/threonine-protein kinase N2 isoform X3

    UniProtKB/Swiss-Prot
    Q16513
    Conserved Domains (3) summary
    cd08687
    Location:64147
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    smart00220
    Location:336590
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:331656
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
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