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Pkn2 protein kinase N2 [ Mus musculus (house mouse) ]

Gene ID: 109333, updated on 12-May-2024

Summary

Official Symbol
Pkn2provided by MGI
Official Full Name
protein kinase N2provided by MGI
Primary source
MGI:MGI:109211
See related
Ensembl:ENSMUSG00000004591 AllianceGenome:MGI:109211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRK2; Stk7; Prkcl2; 6030436C20Rik
Summary
Predicted to enable RNA polymerase binding activity; histone deacetylase binding activity; and protein serine/threonine kinase activity. Involved in apical junction assembly. Located in apical junction complex; cytoplasm; and nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human PKN2 (protein kinase N2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 11.9), bladder adult (RPKM 10.0) and 28 other tissues See more
Orthologs
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Genomic context

See Pkn2 in Genome Data Viewer
Location:
3 H1; 3 66.69 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (142496663..142587765, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (142790902..142882004, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1270 Neighboring gene STARR-seq mESC enhancer starr_09161 Neighboring gene STARR-positive B cell enhancer mm9_chr3:142371757-142372058 Neighboring gene kynurenine aminotransferase 3 Neighboring gene STARR-seq mESC enhancer starr_09162 Neighboring gene STARR-positive B cell enhancer ABC_E6141 Neighboring gene STARR-seq mESC enhancer starr_09163 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:142427870-142428053 Neighboring gene general transcription factor IIB Neighboring gene predicted gene, 24457 Neighboring gene predicted gene, 25965 Neighboring gene RIKEN cDNA 9530052C20 gene Neighboring gene STARR-positive B cell enhancer mm9_chr3:142545199-142545499 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:142562224-142562407 Neighboring gene STARR-seq mESC enhancer starr_09164 Neighboring gene STARR-seq mESC enhancer starr_09165 Neighboring gene STARR-seq mESC enhancer starr_09166 Neighboring gene predicted gene, 33289 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apical junction assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apical junction assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in apical junction complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical junction complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase N2
Names
PKN gamma
protein kinase C-like 2
protein-kinase C-related kinase 2
serine/threonine kinase 7
NP_848769.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178654.4NP_848769.2  serine/threonine-protein kinase N2

    See identical proteins and their annotated locations for NP_848769.2

    Status: VALIDATED

    Source sequence(s)
    AK049713, AK133298, AK140746, BY729073
    Consensus CDS
    CCDS51084.1
    UniProtKB/Swiss-Prot
    Q3TBR3, Q80WS2, Q8BJL7, Q8BL62, Q8BWW9
    UniProtKB/TrEMBL
    G3UZM9
    Related
    ENSMUSP00000039566.9, ENSMUST00000043812.15
    Conserved Domains (6) summary
    cd08687
    Location:389472
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:42107
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11631
    Location:128201
    HR1_PKN2_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    cd11635
    Location:209282
    HR1_PKN2_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N2
    smart00220
    Location:661915
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:656981
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    142496663..142587765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)