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Ezr ezrin [ Rattus norvegicus (Norway rat) ]

Gene ID: 54319, updated on 11-Apr-2024

Summary

Official Symbol
Ezrprovided by RGD
Official Full Name
ezrinprovided by RGD
Primary source
RGD:621161
See related
Ensembl:ENSRNOG00000018524 AllianceGenome:RGD:621161
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Vil2
Summary
Enables protein domain specific binding activity. Involved in epithelial cell differentiation and filopodium assembly. Located in several cellular components, including basolateral plasma membrane; microspike; and microvillus. Orthologous to human EZR (ezrin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 1285.2), Lung (RPKM 593.2) and 6 other tissues See more
Orthologs
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Genomic context

See Ezr in Genome Data Viewer
Location:
1q11
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (49373033..49416573, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (46967961..47011505, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (47287872..47331412, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene dynein light chain Tctex-type 1 Neighboring gene synaptotagmin-like 3 Neighboring gene uncharacterized LOC120099117 Neighboring gene RNA, U6 small nuclear 546 Neighboring gene radial spoke head 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC94076

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables S100 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A catalytic subunit binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A regulatory subunit binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in astral microtubule organization IEA
Inferred from Electronic Annotation
more info
 
involved_in astral microtubule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cortical microtubule organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cortical microtubule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in establishment of centrosome localization IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of centrosome localization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial barrier IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in establishment of epithelial cell apical/basal polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment or maintenance of apical/basal cell polarity IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within establishment or maintenance of apical/basal cell polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in filopodium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in gland morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal D-glucose absorption IEA
Inferred from Electronic Annotation
more info
 
involved_in intestinal D-glucose absorption ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in membrane to membrane docking IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane to membrane docking ISO
Inferred from Sequence Orthology
more info
 
involved_in microvillus assembly IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of early endosome to late endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein localization to early endosome IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to early endosome ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynaptic actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
involved_in postsynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase A signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell cortex IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to cell cortex ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex localization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex localization ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within receptor internalization ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microvillus length IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of microvillus length ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of organelle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of organelle assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of organelle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in sphingosine-1-phosphate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingosine-1-phosphate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in terminal web assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in terminal web assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Schwann cell microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in actin filament IEA
Inferred from Electronic Annotation
more info
 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in apical part of cell IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in astrocyte projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border IEA
Inferred from Electronic Annotation
more info
 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cell tip IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse IEA
Inferred from Electronic Annotation
more info
 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in microspike IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in uropod IEA
Inferred from Electronic Annotation
more info
 
located_in uropod ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ezrin
Names
cytovillin
p81
villin-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019357.1NP_062230.1  ezrin

    See identical proteins and their annotated locations for NP_062230.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081958
    UniProtKB/Swiss-Prot
    P31977, Q5WQV4, Q66H97, Q8VHK3
    UniProtKB/TrEMBL
    A0A8I5Y4R7, A6KP14
    Related
    ENSRNOP00000046593.2, ENSRNOT00000046746.4
    Conserved Domains (5) summary
    smart00295
    Location:7206
    B41; Band 4.1 homologues
    cd13194
    Location:200296
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00373
    Location:92206
    FERM_M; FERM central domain
    pfam00769
    Location:338586
    ERM; Ezrin/radixin/moesin family
    pfam09379
    Location:971
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    49373033..49416573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)