Ezr ezrin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ezrprovided by MGI
Official Full Name: ezrinprovided by MGI
Primary source: MGI:MGI:98931
See related: Ensembl:ENSMUSG00000052397 AllianceGenome:MGI:98931
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p81; Vil2
Summary: Enables disordered domain specific binding activity and protein C-terminus binding activity. Involved in several processes, including intestinal D-glucose absorption; positive regulation of protein localization to plasma membrane; and terminal web assembly. Acts upstream of or within establishment or maintenance of apical/basal cell polarity and receptor internalization. Located in several cellular components, including brush border; microvillus; and uropod. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human EZR (ezrin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in large intestine adult (RPKM 105.7), small intestine adult (RPKM 102.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17; 17 A1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (7005530..7050179, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (6738131..6782780, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylation.
Title: Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylation.
The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin and ezrin in podocytes was associated with the stability of the PC/ezrin complex.
Title: The SGK3-triggered ubiquitin-proteasome degradation of podocalyxin (PC) and ezrin in podocytes was associated with the stability of the PC/ezrin complex.
our study revealed that ezrin is not necessary for the maintenance of glomerular foot process integrity at the basal condition, but it does play an important role in the regulation of actin dynamics in glomerular podocytes through the regulation of Rac1 signalling.
Title: Loss of ezrin expression reduced the susceptibility to the glomerular injury in mice.
This study demonstrated that developmental stages, Ezr has highest fold difference in early embryonic and postnatal stages.
Title: Deciphering brain-specific transcriptomic expression of Ezr, Rad and Msn genes in the development of Mus musculus.
data demonstrate that ezrin is a novel molecular regulator of B cell-associated lupus pathology.
Title: Cutting Edge: Deletion of Ezrin in B Cells of Lyn-Deficient Mice Downregulates Lupus Pathology.
In summary, the authors have described a direct link from CFTR to Ezrin to PI3K/AKT signaling that is disrupted in cystic fibrosis, and thus promotes hyper-inflammation and weakens phagocytosis.
Title: Ezrin links CFTR to TLR4 signaling to orchestrate anti-bacterial immune response in macrophages.
In summary, the data show that urokinase-type plasminogen activator/ the urokinase-type plasminogen activator receptor binding promotes synaptic repair in the ischemic brain via ezrin-mediated reorganization of the actin cytoskeleton in the postsynaptic terminal.
Title: Urokinase-type plasminogen activator (uPA) promotes ezrin-mediated reorganization of the synaptic cytoskeleton in the ischemic brain.
Ezrin level may serve as a differential diagnostic and/or prognostic biomarker for high and low lymphatic metastasis -Hepatocellular carcinoma (HCC)and may be beneficial in the diagnosis of HCC disease
Title: Ezrin as a possible diagnostic and/or prognostic biomarker in mice lymphatic metastatic hepatocellular carcinoma in vivo.
Inactivation of SHIP2 leads to increased microvilli formation and solute reabsorption by the renal proximal tubule and was associated with hyperactivated ezrin/radixin/moesin proteins and increased Rho-GTP.
Title: The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating the activation of ERM proteins.
high actin-ezrin intensity area restricts the lateral movement of B cell receptors upon stimulation, reducing receptor clustering and signaling
Title: Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Vil2 (e-PCR), detects polymorphism
- UniSTS:274189

D15Mit19 (e-PCR), detects polymorphism
- UniSTS:127557

Vil2 (e-PCR), detects polymorphism
- UniSTS:144757

X60671 (e-PCR)
- UniSTS:125820

Vil2 (e-PCR), detects polymorphism
- UniSTS:507307

AW146364 (e-PCR)
- UniSTS:180957

D18S492 (e-PCR)
- UniSTS:15338

RH125205 (e-PCR)
- UniSTS:162027

NoName (e-PCR)
- UniSTS:237563

Homology

Homologs of the Ezr gene: The Ezr gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 349 organisms have orthologs with human gene Ezr
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables S100 protein binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables disordered domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton reorganization	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in astral microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cortical microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in establishment of centrosome localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment or maintenance of apical/basal cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in intestinal D-glucose absorption	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in microvillus assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to early endosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of protein localization to early endosome	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell cortex	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of microvillus length	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of organelle assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in sphingosine-1-phosphate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in terminal web assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Schwann cell microvillus	ISO Inferred from Sequence Orthology more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cell tip	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of membrane	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in filopodium	ISO Inferred from Sequence Orthology more info
colocalizes_with focal adhesion	ISO Inferred from Sequence Orthology more info
colocalizes_with immunological synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in microspike	ISO Inferred from Sequence Orthology more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in microvillus	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in uropod	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ezrin

Names: cytovillin; villin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.