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Ezr ezrin [ Mus musculus (house mouse) ]

Gene ID: 22350, updated on 18-Sep-2024

Summary

Official Symbol
Ezrprovided by MGI
Official Full Name
ezrinprovided by MGI
Primary source
MGI:MGI:98931
See related
Ensembl:ENSMUSG00000052397 AllianceGenome:MGI:98931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p81; Vil2
Summary
Enables disordered domain specific binding activity and protein C-terminus binding activity. Involved in several processes, including intestinal D-glucose absorption; positive regulation of protein localization to plasma membrane; and terminal web assembly. Acts upstream of or within establishment or maintenance of apical/basal cell polarity and receptor internalization. Located in several cellular components, including brush border; microvillus; and uropod. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human EZR (ezrin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 105.7), small intestine adult (RPKM 102.3) and 24 other tissues See more
Orthologs
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Genomic context

See Ezr in Genome Data Viewer
Location:
17 A1; 17 4.38 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (7005530..7050179, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (6738131..6782780, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancers mm9_chr17:6600655-6600955 and mm9_chr17:6860503-6860804 Neighboring gene dynein light chain Tctex-type 1F Neighboring gene synaptotagmin-like 3 Neighboring gene predicted gene, 36309 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:6949847-6950048 Neighboring gene STARR-seq mESC enhancer starr_41734 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:6982099-6982286 Neighboring gene STARR-positive B cell enhancer ABC_E2469 Neighboring gene RIKEN cDNA 4933426B08 gene Neighboring gene predicted gene 2885 Neighboring gene STARR-seq mESC enhancer starr_41739 Neighboring gene microRNA 692-1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC107499

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables S100 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables disordered domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A catalytic subunit binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase A regulatory subunit binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in actin filament bundle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in astral microtubule organization IEA
Inferred from Electronic Annotation
more info
 
involved_in astral microtubule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cAMP IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cortical microtubule organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cortical microtubule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of centrosome localization IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of centrosome localization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial barrier IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment or maintenance of apical/basal cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in filopodium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in filopodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal D-glucose absorption IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in leukocyte cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane to membrane docking IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in microvillus assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-2 production IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of early endosome to late endosome transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of early endosome to late endosome transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein localization to early endosome IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to early endosome ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to plasma membrane IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynaptic actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase A signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell cortex IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to cell cortex ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex localization IEA
Inferred from Electronic Annotation
more info
 
involved_in protein-containing complex localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microvillus length IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of organelle assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of organelle assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of organelle assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in sphingosine-1-phosphate receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingosine-1-phosphate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in terminal web assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Schwann cell microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in actin filament ISO
Inferred from Sequence Orthology
more info
 
located_in actin filament ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in apical part of cell IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in astrocyte projection ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cell tip ISO
Inferred from Sequence Orthology
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
is_active_in filopodium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in filopodium IEA
Inferred from Electronic Annotation
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in microspike ISO
Inferred from Sequence Orthology
more info
 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus membrane ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane raft IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in uropod IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ezrin
Names
cytovillin
villin-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009510.2NP_033536.2  ezrin

    See identical proteins and their annotated locations for NP_033536.2

    Status: VALIDATED

    Source sequence(s)
    AK035271, AK145707, BC098502
    Consensus CDS
    CCDS37428.1
    UniProtKB/Swiss-Prot
    P26040, Q80ZT8, Q9DCI1
    UniProtKB/TrEMBL
    Q3TCP5, Q3UL48, Q3UXR4, Q4KML7
    Related
    ENSMUSP00000063734.7, ENSMUST00000064234.7
    Conserved Domains (3) summary
    smart00295
    Location:7206
    B41; Band 4.1 homologues
    cd13194
    Location:200296
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:338586
    ERM; Ezrin/radixin/moesin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    7005530..7050179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)