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EZR ezrin [ Homo sapiens (human) ]

Gene ID: 7430, updated on 26-Sep-2021

Summary

Official Symbol
EZRprovided by HGNC
Official Full Name
ezrinprovided by HGNC
Primary source
HGNC:HGNC:12691
See related
Ensembl:ENSG00000092820 MIM:123900
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CVL; CVIL; VIL2; HEL-S-105
Summary
The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta (RPKM 124.6), small intestine (RPKM 120.8) and 25 other tissues See more
Orthologs
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Genomic context

See EZR in Genome Data Viewer
Location:
6q25.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (158765744..158819368, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (159186780..159240400, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene synaptotagmin like 3 Neighboring gene AMZ2 pseudogene 2 Neighboring gene microRNA 3918 Neighboring gene EZR antisense RNA 1 Neighboring gene oligosaccharyltransferase complex subunit pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 2901

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide interaction study of smoking and bladder cancer risk.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
siRNA knockdown of EZR enhances HIV-1 replication; HIV-1 replication is restricted by EZR PubMed
Knockdown of ezrin by shRNA results in the production of virus with decreased infectivity and the enhancement of HIV-1-induced cell-cell fusion PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Interaction of the X4-tropic protein HIV-1 gp120 with CD4 augments ezrin and moesin phosphorylation in human permissive T cells, thereby regulating ezrin-moesin activation PubMed
env HIV-1 gp120-mediated CD4 engagement is involved in the induction of susceptibility of primary human T lymphocytes to CD95-mediated apoptosis through ezrin phosphorylation and ezrin-to-CD95 association PubMed
env Treatment of CD4+ T cells with HIV-1 gp120 induces CD95-mediated apoptosis, CD95/ERM protein (ezrin, radixin, moesin) colocalization and stable ezrin phosphorylation PubMed
env Ezrin and moesin are structural proteins that bind to the cellular membrane and interact with HIV-1 gp120/gp160 in CD4- and Gal-C-negative brain cells; ezrin and moesin play a role as gp120/gp160 binding proteins during the uptake of HIV PubMed
Nef nef Knockdown of ezrin by siRNA enhances HIV-1 infectivity and inhibits HIV-1 Nef ability to increase virus infectivity, neither activity is affected by ezrin overexpression PubMed
Pr55(Gag) gag HIV-1 Gag co-localizes with ezrin-radixin-moesin proteins at polarized HIV-1 assembly sites in human T cells PubMed
gag The cytoskeletal proteins ezrin, moesin, and cofilin are incorporated into HIV-1 particles, presumably through their interaction with actin which binds to the nucleocapsid domain of HIV-1 Gag PubMed
Tat tat Expression of HIV-1 Tat downregulates the abundance of ezrin (EZR) in the nucleoli of Jurkat T-cells PubMed
Vpr vpr HIV-1 Vpr-induced downregulation of sodium hydrogen exchanger, isoform 1 (NHE1), in Vpr(+) virus infected cells leads to acidification of cells, loss of ezrin, radixin and moesin (ERM) protein complex and decrease of AKT phosphorylation PubMed
vpr HIV-1 Vpr-expressing Jurkat T cell clones showed a significant upregulation of ezrin protein expression, indicating a role of Vpr in microfilament system assembly PubMed
matrix gag HIV-1 MA interacts with EZR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1584, FLJ26216, DKFZp762H157

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA binding HDA PubMed 
enables S100 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables actin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cadherin binding HDA PubMed 
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables microtubule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A catalytic subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase A regulatory subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular protein-containing complex localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cAMP IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cortical microtubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of endothelial barrier IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT involved_in establishment of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intestinal D-glucose absorption IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte cell-cell adhesion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in membrane to membrane docking IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in microvillus assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphatidylinositol-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cellular protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of early endosome to late endosome transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein localization to early endosome IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase A signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor internalization IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of microvillus length IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of organelle assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of organelle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sphingosine-1-phosphate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in terminal web assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Schwann cell microvillus IEA
Inferred from Electronic Annotation
more info
 
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in astrocyte projection IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in brush border ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell body IEA
Inferred from Electronic Annotation
more info
 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell tip IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
located_in cortical cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic side of apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion HDA PubMed 
colocalizes_with focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 
located_in microspike IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in uropod IEA
Inferred from Electronic Annotation
more info
 
located_in vesicle HDA PubMed 

General protein information

Preferred Names
ezrin
Names
cytovillin 2
epididymis secretory protein Li 105
p81
villin 2 (ezrin)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052952.1 RefSeqGene

    Range
    6190..58677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001111077.2NP_001104547.1  ezrin

    See identical proteins and their annotated locations for NP_001104547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC013903, DA754543
    Consensus CDS
    CCDS5258.1
    UniProtKB/Swiss-Prot
    P15311
    Related
    ENSP00000356042.3, ENST00000367075.4
    Conserved Domains (3) summary
    smart00295
    Location:7206
    B41; Band 4.1 homologues
    cd13194
    Location:200296
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:338586
    ERM; Ezrin/radixin/moesin family
  2. NM_003379.5NP_003370.2  ezrin

    See identical proteins and their annotated locations for NP_003370.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC013903, DA783190
    Consensus CDS
    CCDS5258.1
    UniProtKB/Swiss-Prot
    P15311
    Related
    ENSP00000338934.7, ENST00000337147.11
    Conserved Domains (3) summary
    smart00295
    Location:7206
    B41; Band 4.1 homologues
    cd13194
    Location:200296
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00769
    Location:338586
    ERM; Ezrin/radixin/moesin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    158765744..158819368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536110.1XP_011534412.1  ezrin isoform X1

    See identical proteins and their annotated locations for XP_011534412.1

    Conserved Domains (3) summary
    cd13194
    Location:64160
    FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family
    pfam00373
    Location:2070
    FERM_M; FERM central domain
    pfam00769
    Location:202450
    ERM; Ezrin/radixin/moesin family
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