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Flt1 Fms related receptor tyrosine kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54251, updated on 13-Apr-2024

Summary

Official Symbol
Flt1provided by RGD
Official Full Name
Fms related receptor tyrosine kinase 1provided by RGD
Primary source
RGD:2621
See related
Ensembl:ENSRNOG00000000940 AllianceGenome:RGD:2621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FLT-1; VEGFR-1
Summary
Enables ATP binding activity; growth factor binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including liver regeneration; negative regulation of vascular endothelial growth factor production; and positive regulation of cell population proliferation. Located in extracellular space and plasma membrane. Used to study corneal neovascularization. Biomarker of breast cancer; diabetic retinopathy; liver cirrhosis; myocardial infarction; and vascular dementia. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 293.4), Heart (RPKM 182.9) and 8 other tissues See more
Orthologs
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Genomic context

See Flt1 in Genome Data Viewer
Location:
12p11
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (12333050..12504750)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (7296899..7468626)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (9033993..9205886)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 46, member 3 Neighboring gene proteasome maturation protein Neighboring gene interferon-induced transmembrane protein 2-like Neighboring gene uncharacterized LOC102547586 Neighboring gene uncharacterized LOC120095883 Neighboring gene uncharacterized LOC134481261 Neighboring gene poly(A) specific ribonuclease subunit PAN3 Neighboring gene uncharacterized LOC134481260

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables placental growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables placental growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables vascular endothelial growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables vascular endothelial growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables vascular endothelial growth factor receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables vascular endothelial growth factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in hyaloid vascular plexus regression ISO
Inferred from Sequence Orthology
more info
 
involved_in hyaloid vascular plexus regression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in monocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular endothelial growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
NOT involved_in positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial growth factor receptor-1 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
vascular endothelial growth factor receptor 1
Names
FMS-like tyrosine kinase 1
Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
tyrosine-protein kinase receptor FLT
vascular endothelial growth factor receptor 1-like
vascular endothelial growth factor/vascular permeability factor receptor
NP_001296310.1
NP_062179.2
XP_008767220.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309381.1NP_001296310.1  vascular endothelial growth factor receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001296310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A6K198, Q9JJ08
    Conserved Domains (4) summary
    cd00096
    Location:451549
    Ig; Immunoglobulin domain
    smart00408
    Location:569640
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:237328
    IG_like; Immunoglobulin like
    cl11960
    Location:353424
    Ig; Immunoglobulin domain
  2. NM_019306.2NP_062179.2  vascular endothelial growth factor receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_062179.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    P53767
    UniProtKB/TrEMBL
    A6K197
    Related
    ENSRNOP00000001248.2, ENSRNOT00000001248.4
    Conserved Domains (8) summary
    cd00096
    Location:451549
    Ig; Immunoglobulin domain
    smart00408
    Location:676738
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:568640
    IG; Immunoglobulin
    smart00410
    Location:237328
    IG_like; Immunoglobulin like
    pfam07679
    Location:661748
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:8271154
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:353424
    Ig; Immunoglobulin domain
    cl21453
    Location:8191157
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    12333050..12504750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768998.4XP_008767220.1  vascular endothelial growth factor receptor 1 isoform X1

    UniProtKB/TrEMBL
    Q9JJ08
    Conserved Domains (5) summary
    cd00096
    Location:451549
    Ig; Immunoglobulin domain
    smart00408
    Location:569640
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:237328
    IG_like; Immunoglobulin like
    pfam13895
    Location:666736
    Ig_2; Immunoglobulin domain
    cl11960
    Location:353424
    Ig; Immunoglobulin domain