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Flt1 FMS-related tyrosine kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54251, updated on 12-Aug-2018

Summary

Official Symbol
Flt1provided by RGD
Official Full Name
FMS-related tyrosine kinase 1provided by RGD
Primary source
RGD:2621
See related
Ensembl:ENSRNOG00000000940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FLT-1; VEGFR-1
Summary
tyrosine kinase receptor for vascular endothelial growth factor; may play a role in cell proliferation and cell survival [RGD, Feb 2006]
Expression
Biased expression in Lung (RPKM 293.4), Heart (RPKM 182.9) and 8 other tissues See more
Orthologs

Genomic context

See Flt1 in Genome Data Viewer
Location:
12p11
Exon count:
31
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (9033993..9205886)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (10927827..10959880, complement)

Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene proteasome maturation protein Neighboring gene proteasome maturation protein-like Neighboring gene interferon-induced transmembrane protein 2-like Neighboring gene uncharacterized LOC102547586 Neighboring gene poly(A) specific ribonuclease subunit PAN3 Neighboring gene similar to ribosomal protein L18a

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Focal Adhesion, organism-specific biosystem (from WikiPathways)
    Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, organism-specific biosystem (from KEGG)
    Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • Focal adhesion, conserved biosystem (from KEGG)
    Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
  • Neurophilin interactions with VEGF and VEGFR, organism-specific biosystem (from REACTOME)
    Neurophilin interactions with VEGF and VEGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Rheumatoid arthritis, organism-specific biosystem (from KEGG)
    Rheumatoid arthritis, organism-specific biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Rheumatoid arthritis, conserved biosystem (from KEGG)
    Rheumatoid arthritis, conserved biosystemRheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by VEGF, organism-specific biosystem (from REACTOME)
    Signaling by VEGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
    Transcriptional misregulation in cancer, organism-specific biosystem
    Transcriptional misregulation in cancer
  • Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
    Transcriptional misregulation in cancer, conserved biosystem
    Transcriptional misregulation in cancer
  • VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystem (from REACTOME)
    VEGF binds to VEGFR leading to receptor dimerization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • VEGF ligand-receptor interactions, organism-specific biosystem (from REACTOME)
    VEGF ligand-receptor interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
VEGF-A-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
VEGF-A-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
VEGF-B-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
VEGF-B-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
growth factor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
growth factor binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
placental growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
placental growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
vascular endothelial growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of MAPKK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
blood vessel morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
branching involved in blood vessel morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
chemotaxis IEA
Inferred from Electronic Annotation
more info
 
embryonic morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
intracellular receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver regeneration IEP
Inferred from Expression Pattern
more info
PubMed 
monocyte chemotaxis IEA
Inferred from Electronic Annotation
more info
 
monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of vascular endothelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of vascular endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular endothelial growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
NOT positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
post-embryonic camera-type eye morphogenesis ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of smooth muscle contraction IDA
Inferred from Direct Assay
more info
PubMed 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to ethanol IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor receptor-1 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vascular endothelial growth factor receptor-1 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IEA
Inferred from Electronic Annotation
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
vascular endothelial growth factor receptor 1
Names
FMS-like tyrosine kinase 1
Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
tyrosine-protein kinase receptor FLT
vascular endothelial growth factor receptor 1-like
vascular endothelial growth factor/vascular permeability factor receptor
NP_001296310.1
NP_062179.2
XP_008767220.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309381.1NP_001296310.1  vascular endothelial growth factor receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001296310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AABR07035267, AABR07035268, AABR07035269
    Conserved Domains (4) summary
    cd00096
    Location:451549
    Ig; Immunoglobulin domain
    smart00408
    Location:569640
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:237328
    IG_like; Immunoglobulin like
    cl11960
    Location:353424
    Ig; Immunoglobulin domain
  2. NM_019306.2NP_062179.2  vascular endothelial growth factor receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_062179.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AABR07035267, AABR07035268, AABR07035269, AABR07035270, AABR07035271
    UniProtKB/TrEMBL
    G3V633
    Related
    ENSRNOP00000001248.1, ENSRNOT00000001248.3
    Conserved Domains (8) summary
    cd00096
    Location:451549
    Ig; Immunoglobulin domain
    smart00408
    Location:676738
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:568640
    IG; Immunoglobulin
    smart00410
    Location:237328
    IG_like; Immunoglobulin like
    pfam07679
    Location:661748
    I-set; Immunoglobulin I-set domain
    pfam07714
    Location:8271154
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:353424
    Ig; Immunoglobulin domain
    cl21453
    Location:8191157
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

    Range
    9033993..9205886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008768998.2XP_008767220.1  vascular endothelial growth factor receptor 1 isoform X1

    Conserved Domains (5) summary
    cd00096
    Location:451549
    Ig; Immunoglobulin domain
    smart00408
    Location:569640
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:237328
    IG_like; Immunoglobulin like
    pfam13895
    Location:666736
    Ig_2; Immunoglobulin domain
    cl11960
    Location:353424
    Ig; Immunoglobulin domain

Alternate Rn_Celera

Genomic

  1. AC_000080.1 Alternate Rn_Celera

    Range
    9039046..9210055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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