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LUC7L2 LUC7 like 2, pre-mRNA splicing factor [ Homo sapiens (human) ]

Gene ID: 51631, updated on 7-Jun-2020

Summary

Official Symbol
LUC7L2provided by HGNC
Official Full Name
LUC7 like 2, pre-mRNA splicing factorprovided by HGNC
Primary source
HGNC:HGNC:21608
See related
Ensembl:ENSG00000146963 MIM:613056
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-59; CGI-74; LUC7B2
Summary
This gene encodes a protein that contains a C2H2-type zinc finger, coiled-coil region and arginine, serine-rich (RS) domain. A similar protein in mouse interacts with sodium channel modifier 1, and the encoded protein may be involved in the recognition of non-consensus splice donor sites in association with the U1 snRNP spliceosomal subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Expression
Ubiquitous expression in thyroid (RPKM 34.6), bone marrow (RPKM 32.4) and 25 other tissues See more
Orthologs

Genomic context

See LUC7L2 in Genome Data Viewer
Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (139340359..139423457)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139025105..139108203)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37a pseudogene 5 Neighboring gene ubinuclein 2 Neighboring gene RNA, U6 small nuclear 206, pseudogene Neighboring gene FMC1-LUC7L2 readthrough Neighboring gene tRNA-Arg (anticodon CCT) 4-1 Neighboring gene formation of mitochondrial complex V assembly factor 1 homolog Neighboring gene uncharacterized LOC100129148 Neighboring gene killer cell lectin like receptor G2 Neighboring gene RNA, U6 small nuclear 911, pseudogene Neighboring gene ST13, Hsp70 interacting protein pseudogene 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify putative RNA-binding protein Luc7-like 2 (LUC7L2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify putative RNA-binding protein Luc7-like 2 (LUC7L2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify putative RNA-binding protein Luc7-like 2 (LUC7L2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify putative RNA-binding protein Luc7-like 2 (LUC7L2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough FMC1-LUC7L2

Readthrough gene: FMC1-LUC7L2, Included gene: FMC1

Homology

Clone Names

  • FLJ10657

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA splice site selection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
putative RNA-binding protein Luc7-like 2
Names
LUC7-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030012.1 RefSeqGene

    Range
    4981..88079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001244585.1NP_001231514.1  putative RNA-binding protein Luc7-like 2 isoform 3

    See identical proteins and their annotated locations for NP_001231514.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC083880, AK298166, AU144525, BC017163
    Consensus CDS
    CCDS59085.1
    UniProtKB/Swiss-Prot
    Q9Y383
    Related
    ENSP00000441604.1, ENST00000541170.7
    Conserved Domains (1) summary
    pfam03194
    Location:14238
    LUC7; LUC7 N_terminus
  2. NM_001270643.1NP_001257572.1  putative RNA-binding protein Luc7-like 2 isoform 4

    See identical proteins and their annotated locations for NP_001257572.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AU144525, BC017163, BC042625, HY018775
    Consensus CDS
    CCDS59510.1
    UniProtKB/Swiss-Prot
    Q9Y383
    Related
    ENSP00000483438.1, ENST00000619796.4
    Conserved Domains (1) summary
    pfam03194
    Location:24240
    LUC7; LUC7 N_terminus
  3. NM_016019.5NP_057103.2  putative RNA-binding protein Luc7-like 2 isoform 1

    See identical proteins and their annotated locations for NP_057103.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC017163, HY018775
    Consensus CDS
    CCDS43656.1
    UniProtKB/Swiss-Prot
    Q9Y383
    Related
    ENSP00000347005.4, ENST00000354926.9
    Conserved Domains (1) summary
    pfam03194
    Location:5241
    LUC7; LUC7 N_terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    139340359..139423457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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