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FMC1 formation of mitochondrial complex V assembly factor 1 homolog [ Homo sapiens (human) ]

Gene ID: 154791, updated on 1-Jun-2020

Summary

Official Symbol
FMC1provided by HGNC
Official Full Name
formation of mitochondrial complex V assembly factor 1 homologprovided by HGNC
Primary source
HGNC:HGNC:26946
See related
Ensembl:ENSG00000164898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C7orf55; HSPC268
Expression
Broad expression in testis (RPKM 11.0), kidney (RPKM 8.7) and 25 other tissues See more
Orthologs

Genomic context

See FMC1 in Genome Data Viewer
Location:
7q34
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (139340450..139346328)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139025196..139031065)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37a pseudogene 5 Neighboring gene ubinuclein 2 Neighboring gene RNA, U6 small nuclear 206, pseudogene Neighboring gene FMC1-LUC7L2 readthrough Neighboring gene tRNA-Arg (anticodon CCT) 4-1 Neighboring gene LUC7 like 2, pre-mRNA splicing factor Neighboring gene uncharacterized LOC100129148 Neighboring gene killer cell lectin like receptor G2 Neighboring gene RNA, U6 small nuclear 911, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough FMC1-LUC7L2

Readthrough gene: FMC1-LUC7L2, Included gene: LUC7L2

Homology

Clone Names

  • FLJ35699

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mitochondrial proton-transporting ATP synthase complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of type B pancreatic cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein FMC1 homolog
Names
ATP synthase assembly factor FMC1, mitochondrial
UPF0562 protein C7orf55
formation of mitochondrial complexes 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_197964.5NP_932068.2  protein FMC1 homolog

    See identical proteins and their annotated locations for NP_932068.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the supproted protein.
    Source sequence(s)
    AC083880, BC008467, CB125801
    Consensus CDS
    CCDS5853.1
    UniProtKB/Swiss-Prot
    Q96HJ9
    Related
    ENSP00000297534.6, ENST00000297534.7

RNA

  1. NR_073058.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' exon and includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
    Source sequence(s)
    AA620996, AC083880, BC008467, BU852633
  2. NR_073059.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
    Source sequence(s)
    AC083880, BC008467, BU852633
  3. NR_073060.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
    Source sequence(s)
    AA393224, AC083880, BC008467, BU852633

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    139340450..139346328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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