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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001025778.2 → NP_001020949.1 inactive serine/threonine-protein kinase VRK3 isoform 2
See identical proteins and their annotated locations for NP_001020949.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a protein (isoform 2) that is shorter than isoform 1.
- Source sequence(s)
-
AC011452, AV706241
- Consensus CDS
-
CCDS33076.1
- UniProtKB/Swiss-Prot
-
Q8IV63
- Related
- ENSP00000366210.1, ENST00000377011.6
- Conserved Domains (4) summary
-
- COG0515
Location:161 → 417
- SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
- pfam12773
Location:5 → 31
- DZR; Double zinc ribbon
- pfam13240
Location:4 → 26
- zinc_ribbon_2; zinc-ribbon domain
- cl21453
Location:105 → 407
- PKc_like; Protein Kinases, catalytic domain
-
NM_001308420.3 → NP_001295349.1 inactive serine/threonine-protein kinase VRK3 isoform 3
See identical proteins and their annotated locations for NP_001295349.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3) lacks several exons and uses an alternate 3' terminal exon that results in a different 3' UTR and novel 3' coding region compared to variant 1. It encodes isoform 3, which is shorter than and has a distinct C-terminus compared to isoform 1.
- Source sequence(s)
-
BC023556, BP335032
- Consensus CDS
-
CCDS77334.1
- UniProtKB/Swiss-Prot
-
Q8IV63
- Related
- ENSP00000472541.1, ENST00000594092.5
- Conserved Domains (5) summary
-
- COG0515
Location:211 → 412
- SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
- pfam12773
Location:5 → 31
- DZR; Double zinc ribbon
- pfam13240
Location:4 → 26
- zinc_ribbon_2; zinc-ribbon domain
- pfam15087
Location:82 → 150
- DUF4551; Protein of unknown function (DUF4551)
- cl21453
Location:155 → 406
- PKc_like; Protein Kinases, catalytic domain
-
NM_016440.4 → NP_057524.3 inactive serine/threonine-protein kinase VRK3 isoform 1
See identical proteins and their annotated locations for NP_057524.3
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
- Source sequence(s)
-
AC011452, AF514788, AV706241
- Consensus CDS
-
CCDS12791.1
- UniProtKB/Swiss-Prot
-
Q8IV63
- UniProtKB/TrEMBL
-
A0A024QZI4
- Related
- ENSP00000324636.2, ENST00000316763.8
- Conserved Domains (5) summary
-
- COG0515
Location:211 → 467
- SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
- pfam12773
Location:5 → 31
- DZR; Double zinc ribbon
- pfam13240
Location:4 → 26
- zinc_ribbon_2; zinc-ribbon domain
- pfam15087
Location:82 → 150
- DUF4551; Protein of unknown function (DUF4551)
- cl21453
Location:155 → 457
- PKc_like; Protein Kinases, catalytic domain