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Vrk3 vaccinia related kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 101568, updated on 27-Nov-2024

Summary

Official Symbol
Vrk3provided by MGI
Official Full Name
vaccinia related kinase 3provided by MGI
Primary source
MGI:MGI:2182465
See related
Ensembl:ENSMUSG00000002205 AllianceGenome:MGI:2182465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables protein phosphatase activator activity and protein phosphatase binding activity. Acts upstream of or within negative regulation of ERK1 and ERK2 cascade. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Used to study autism spectrum disorder. Orthologous to human VRK3 (VRK serine/threonine kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 35.9), large intestine adult (RPKM 18.2) and 28 other tissues See more
Orthologs
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Genomic context

See Vrk3 in Genome Data Viewer
Location:
7 B3; 7 28.9 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44398049..44426939)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44748629..44777515)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18813 Neighboring gene IZUMO family member 2 Neighboring gene zinc finger protein 473 Neighboring gene STARR-positive B cell enhancer ABC_E2823 Neighboring gene STARR-seq mESC enhancer starr_18814 Neighboring gene STARR-seq mESC enhancer starr_18815 Neighboring gene predicted gene, 29791 Neighboring gene STARR-seq mESC enhancer starr_18816 Neighboring gene STARR-positive B cell enhancer ABC_E1086 Neighboring gene activating transcription factor 5 Neighboring gene interleukin 4 induced 1B Neighboring gene nucleoporin 62

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase activator activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase VRK3
Names
inactive serine/threonine-protein kinase VRK3
serine/threonine-protein pseudokinase VRK3
NP_001406082.1
NP_001406083.1
NP_001406084.1
NP_001406085.1
NP_001406086.1
NP_001406087.1
NP_001406088.1
NP_001406089.1
NP_598706.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419153.1NP_001406082.1  serine/threonine-protein kinase VRK3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231
  2. NM_001419154.1NP_001406083.1  serine/threonine-protein kinase VRK3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC150895
  3. NM_001419155.1NP_001406084.1  serine/threonine-protein kinase VRK3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC150895
    Related
    ENSMUST00000136069.9
  4. NM_001419156.1NP_001406085.1  serine/threonine-protein kinase VRK3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC150895
    Related
    ENSMUST00000135783.2
  5. NM_001419157.1NP_001406086.1  serine/threonine-protein kinase VRK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231
    UniProtKB/Swiss-Prot
    Q8K3G5, Q921W6
    UniProtKB/TrEMBL
    Q3TAR6
  6. NM_001419158.1NP_001406087.1  serine/threonine-protein kinase VRK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231
    UniProtKB/Swiss-Prot
    Q8K3G5, Q921W6
    UniProtKB/TrEMBL
    Q3TAR6
  7. NM_001419159.1NP_001406088.1  serine/threonine-protein kinase VRK3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231
    UniProtKB/Swiss-Prot
    Q8K3G5, Q921W6
    UniProtKB/TrEMBL
    Q3TAR6
  8. NM_001419160.1NP_001406089.1  serine/threonine-protein kinase VRK3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC150895
  9. NM_133945.2NP_598706.1  serine/threonine-protein kinase VRK3 isoform 1

    See identical proteins and their annotated locations for NP_598706.1

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231
    Consensus CDS
    CCDS21214.1
    UniProtKB/Swiss-Prot
    Q8K3G5, Q921W6
    UniProtKB/TrEMBL
    Q3TAR6
    Related
    ENSMUSP00000002275.9, ENSMUST00000002275.15
    Conserved Domains (2) summary
    pfam13240
    Location:426
    zinc_ribbon_2; zinc-ribbon domain
    cl21453
    Location:134436
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_185025.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231
    Related
    ENSMUST00000147952.9
  2. NR_185026.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231
  3. NR_185027.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC150895, AC158231

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44398049..44426939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)