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PRKN parkin RBR E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 5071, updated on 17-Oct-2021

Summary

Official Symbol
PRKNprovided by HGNC
Official Full Name
parkin RBR E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:HGNC:8607
See related
Ensembl:ENSG00000185345 MIM:602544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDJ; AR-JP; LPRS2; PARK2
Summary
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 3.6), kidney (RPKM 3.5) and 21 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See PRKN in Genome Data Viewer
Location:
6q26
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (161347417..162727802, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (161768449..163148798, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4197 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene uncharacterized LOC105378094 Neighboring gene Sharpr-MPRA regulatory region 4750 Neighboring gene uncharacterized LOC105378098 Neighboring gene uncharacterized LOC105378097 Neighboring gene uncharacterized LOC105369171 Neighboring gene keratin 8 pseudogene 44 Neighboring gene tRNA-Glu (TTC) 15-1 Neighboring gene VISTA enhancer hs1358 Neighboring gene parkin coregulated

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
GeneReviews: Not available
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
GeneReviews: Not available
Genome-wide association study of pancreatic cancer in Japanese population.
GeneReviews: Not available
Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
GeneReviews: Not available
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available
Lung cancer
MedGen: C0242379 OMIM: 211980 GeneReviews: Not available
Compare labs
Neoplasm of ovary
MedGen: C0919267 OMIM: 167000 GeneReviews: Not available
Compare labs
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
GeneReviews: Not available
Parkinson disease 2 Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables F-box domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SH3 domain binding TAS
Traceable Author Statement
more info
PubMed 
enables actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cullin family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tubulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin conjugating enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
enables ubiquitin-specific protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in adult locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in aggresome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amyloid fibril formation TAS
Traceable Author Statement
more info
 
involved_in autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagy of mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to dopamine TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to manganese ion TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to unfolded protein TAS
Traceable Author Statement
more info
PubMed 
involved_in central nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in dopamine metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in dopamine uptake involved in synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in free ubiquitin chain polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning IEA
Inferred from Electronic Annotation
more info
 
involved_in macroautophagy TAS
Traceable Author Statement
more info
 
involved_in mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrion to lysosome transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation by host of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of exosomal secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of intralumenal vesicle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitochondrial fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of oxidative stress-induced cell death NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of oxidative stress-induced cell death TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of primary amine oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of reactive oxygen species metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of spontaneous neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in norepinephrine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of autophagy of mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of dendrite extension IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitophagy in response to mitochondrial depolarization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mitophagy in response to mitochondrial depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neurotransmitter uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein linear polyubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein localization to membrane IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of retrograde transport, endosome to Golgi NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K27-linked ubiquitination TAS
Traceable Author Statement
more info
PubMed 
involved_in protein K29-linked ubiquitination TAS
Traceable Author Statement
more info
PubMed 
involved_in protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K6-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K6-linked ubiquitination TAS
Traceable Author Statement
more info
PubMed 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
involved_in protein K63-linked ubiquitination TAS
Traceable Author Statement
more info
PubMed 
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination TAS
Traceable Author Statement
more info
 
involved_in protein localization to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
involved_in protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of dopamine secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of lipid transport TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitochondrion organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitochondrion organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of mitochondrion organization NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein targeting to mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of protein ubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic vesicle transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in startle response IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in zinc ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Lewy body TAS
Traceable Author Statement
more info
PubMed 
part_of Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 
NOT part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in aggresome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with mitochondrion-derived vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase parkin
Names
Parkinson disease (autosomal recessive, juvenile) 2, parkin
parkinson juvenile disease protein 2
parkinson protein 2 E3 ubiquitin protein ligase
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
NP_004553.2
NP_054642.2
NP_054643.2
XP_011534165.1
XP_016866397.1
XP_016866398.1
XP_024302217.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008289.2 RefSeqGene

    Range
    5037..1385386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004562.3NP_004553.2  E3 ubiquitin-protein ligase parkin isoform 1

    See identical proteins and their annotated locations for NP_004553.2

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 1 represents the predominant and full-length form of this gene.
    Source sequence(s)
    AK292590, AL132982, DB023187
    Consensus CDS
    CCDS5281.1
    UniProtKB/Swiss-Prot
    O60260
    UniProtKB/TrEMBL
    X5DR79
    Related
    ENSP00000355865.1, ENST00000366898.6
    Conserved Domains (4) summary
    cd01798
    Location:372
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    smart00647
    Location:313375
    IBR; In Between Ring fingers
    pfam01485
    Location:413453
    IBR; IBR domain, a half RING-finger domain
  2. NM_013987.3NP_054642.2  E3 ubiquitin-protein ligase parkin isoform 2

    See identical proteins and their annotated locations for NP_054642.2

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 2 lacks exons 5 which is present in the full-length variant 1.
    Source sequence(s)
    AK292590, AL132982, DB023187
    Consensus CDS
    CCDS5282.1
    UniProtKB/Swiss-Prot
    O60260
    Related
    ENSP00000355863.1, ENST00000366897.5
    Conserved Domains (4) summary
    cd01798
    Location:372
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    smart00647
    Location:285347
    IBR; In Between Ring fingers
    pfam01485
    Location:385425
    IBR; IBR domain, a half RING-finger domain
  3. NM_013988.3NP_054643.2  E3 ubiquitin-protein ligase parkin isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 3 lacks exons 3 to 5 present in the full-length transcript variant 1.
    Source sequence(s)
    AK292590, AL132982, DB023187
    Consensus CDS
    CCDS5283.1
    UniProtKB/Swiss-Prot
    O60260
    Related
    ENSP00000355862.1, ENST00000366896.5
    Conserved Domains (4) summary
    cd01798
    Location:382
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:158
    UBQ; Ubiquitin homologues
    smart00647
    Location:164226
    IBR; In Between Ring fingers
    pfam01485
    Location:264304
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    161347417..162727802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535863.1XP_011534165.1  E3 ubiquitin-protein ligase parkin isoform X2

    Conserved Domains (4) summary
    cd01798
    Location:372
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    smart00647
    Location:312374
    IBR; In Between Ring fingers
    pfam01485
    Location:412452
    IBR; IBR domain, a half RING-finger domain
  2. XM_024446449.1XP_024302217.1  E3 ubiquitin-protein ligase parkin isoform X3

    Related
    ENST00000674436.1
    Conserved Domains (2) summary
    pfam01485
    Location:234296
    IBR; IBR domain, a half RING-finger domain
    cd16627
    Location:157215
    RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
  3. XM_017010909.2XP_016866398.1  E3 ubiquitin-protein ligase parkin isoform X4

  4. XM_017010908.1XP_016866397.1  E3 ubiquitin-protein ligase parkin isoform X1

RNA

  1. XR_001743443.2 RNA Sequence

    Related
    ENST00000673871.1
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