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PRKN parkin RBR E3 ubiquitin protein ligase [ Homo sapiens (human) ]

Gene ID: 5071, updated on 9-Dec-2018

Summary

Official Symbol
PRKNprovided by HGNC
Official Full Name
parkin RBR E3 ubiquitin protein ligaseprovided by HGNC
Primary source
HGNC:HGNC:8607
See related
Ensembl:ENSG00000185345 MIM:602544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDJ; AR-JP; LPRS2; PARK2
Summary
The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 3.6), kidney (RPKM 3.5) and 21 other tissues See more
Orthologs

Genomic context

See PRKN in Genome Data Viewer
Location:
6q26
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (161347417..162727802, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (161768590..163148834, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene AGPAT4 intronic transcript 1 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene uncharacterized LOC105378094 Neighboring gene uncharacterized LOC105378098 Neighboring gene uncharacterized LOC105378097 Neighboring gene uncharacterized LOC105369171 Neighboring gene keratin 8 pseudogene 44 Neighboring gene tRNA-Glu (TTC) 15-1 Neighboring gene VISTA enhancer hs1358 Neighboring gene parkin coregulated

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Leprosy 2
MedGen: C1843632 OMIM: 607572 GeneReviews: Not available
Compare labs
Lung cancer
MedGen: C0684249 OMIM: 211980 GeneReviews: Not available
Compare labs
Neoplasm of ovary
MedGen: C0919267 OMIM: 167000 GeneReviews: Not available
Compare labs
Parkinson disease 2 Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
NHGRI GWA Catalog
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
NHGRI GWA Catalog
Genome-wide association study of pancreatic cancer in Japanese population.
NHGRI GWA Catalog
Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
NHGRI GWA Catalog

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Alpha-synuclein signaling, organism-specific biosystem (from Pathway Interaction Database)
    Alpha-synuclein signaling, organism-specific biosystem
    Alpha-synuclein signaling
  • Amyloid fiber formation, organism-specific biosystem (from REACTOME)
    Amyloid fiber formation, organism-specific biosystemAmyloid is a term used to describe deposits of fibrillar proteins, typically extracellular. The abnormal accumulation of amyloid, amyloidosis, is a term associated with tissue damage caused by amyloi...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Josephin domain DUBs, organism-specific biosystem (from REACTOME)
    Josephin domain DUBs, organism-specific biosystemThe Josephin domain is present in four human DUBs: Ataxin-3 (ATXN3), ATXN3L, Josephin-1 (JOSD1) and JOSD2. All have been shown to possess DUB activity (Tzveltkov & Breuer 2007, Weeks et al. 2011). Jo...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Mitophagy, organism-specific biosystem (from REACTOME)
    Mitophagy, organism-specific biosystemMitophagy is a specific form of autophagy where mitochondria are specifically targeted for degradation by autophagolysosomes.. In mammals there are a number of known mechanisms of mitophagy. One insu...
  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystem (from WikiPathways)
    Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystemThis pathway describes the Parkin-Ubiquitin proteasome degradation system.
  • Parkinson's disease, organism-specific biosystem (from KEGG)
    Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
  • Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
    Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...
  • Pink/Parkin Mediated Mitophagy, organism-specific biosystem (from REACTOME)
    Pink/Parkin Mediated Mitophagy, organism-specific biosystemThis is the process of selective removal of damaged mitochondria by autophagosomes and subsequent catabolism by lysosomes. In healthy mitochondria, PINK1 is imported to the inner mitochondrial membra...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
F-box domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
SH3 domain binding TAS
Traceable Author Statement
more info
PubMed 
actin binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
cullin family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
phospholipase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
tubulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity NAS
Non-traceable Author Statement
more info
PubMed 
ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
ubiquitin-specific protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
ERAD pathway NAS
Non-traceable Author Statement
more info
PubMed 
adult locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
aggresome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy of mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to dopamine TAS
Traceable Author Statement
more info
PubMed 
cellular response to manganese ion TAS
Traceable Author Statement
more info
PubMed 
cellular response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to unfolded protein TAS
Traceable Author Statement
more info
PubMed 
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
dopamine metabolic process TAS
Traceable Author Statement
more info
PubMed 
dopamine uptake involved in synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
free ubiquitin chain polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning IEA
Inferred from Electronic Annotation
more info
 
macroautophagy TAS
Traceable Author Statement
more info
 
mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion organization ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion to lysosome transport IDA
Inferred from Direct Assay
more info
PubMed 
mitophagy IEA
Inferred from Electronic Annotation
more info
 
negative regulation by host of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of actin filament bundle assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of exosomal secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of intralumenal vesicle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitochondrial fusion ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of oxidative stress-induced cell death NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of oxidative stress-induced cell death TAS
Traceable Author Statement
more info
PubMed 
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of primary amine oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of reactive oxygen species metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of spontaneous neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
norepinephrine metabolic process IEA
Inferred from Electronic Annotation
more info
 
parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of autophagy of mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of dendrite extension IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitochondrial fission ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitochondrial fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitophagy in response to mitochondrial depolarization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of mitophagy in response to mitochondrial depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neurotransmitter uptake IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of proteasomal protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein linear polyubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of protein localization to membrane IC
Inferred by Curator
more info
PubMed 
positive regulation of protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of retrograde transport, endosome to Golgi NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
proteasomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K27-linked ubiquitination TAS
Traceable Author Statement
more info
PubMed 
protein K29-linked ubiquitination TAS
Traceable Author Statement
more info
PubMed 
protein K48-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K6-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K6-linked ubiquitination TAS
Traceable Author Statement
more info
PubMed 
protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein K63-linked ubiquitination NAS
Non-traceable Author Statement
more info
PubMed 
protein K63-linked ubiquitination TAS
Traceable Author Statement
more info
PubMed 
protein autoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein destabilization IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein localization to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cellular response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dopamine secretion TAS
Traceable Author Statement
more info
PubMed 
regulation of glucose metabolic process TAS
Traceable Author Statement
more info
PubMed 
regulation of lipid transport TAS
Traceable Author Statement
more info
PubMed 
regulation of mitochondrial membrane potential IEA
Inferred from Electronic Annotation
more info
 
regulation of mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitochondrion organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitochondrion organization IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of mitochondrion organization NAS
Non-traceable Author Statement
more info
PubMed 
regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein targeting to mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
regulation of protein ubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic vesicle transport NAS
Non-traceable Author Statement
more info
PubMed 
response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
startle response IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process NAS
Non-traceable Author Statement
more info
PubMed 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
PubMed 
zinc ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with LUBAC complex IPI
Inferred from Physical Interaction
more info
PubMed 
Lewy body TAS
Traceable Author Statement
more info
PubMed 
Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 
NOT SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
aggresome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
colocalizes_with mitochondrion-derived vesicle IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
presynapse IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase parkin
Names
Parkinson disease (autosomal recessive, juvenile) 2, parkin
parkinson juvenile disease protein 2
parkinson protein 2 E3 ubiquitin protein ligase
parkinson protein 2, E3 ubiquitin protein ligase (parkin)
NP_004553.2
NP_054642.2
NP_054643.2
XP_011534165.1
XP_016866397.1
XP_016866398.1
XP_024302217.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008289.2 RefSeqGene

    Range
    5001..1385245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004562.3NP_004553.2  E3 ubiquitin-protein ligase parkin isoform 1

    See identical proteins and their annotated locations for NP_004553.2

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 1 represents the predominant and full-length form of this gene.
    Source sequence(s)
    AK292590, AL132982, DB023187
    Consensus CDS
    CCDS5281.1
    UniProtKB/Swiss-Prot
    O60260
    UniProtKB/TrEMBL
    X5DR79
    Related
    ENSP00000355865.1, ENST00000366898.5
    Conserved Domains (4) summary
    cd01798
    Location:372
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    smart00647
    Location:313375
    IBR; In Between Ring fingers
    pfam01485
    Location:413453
    IBR; IBR domain, a half RING-finger domain
  2. NM_013987.2NP_054642.2  E3 ubiquitin-protein ligase parkin isoform 2

    See identical proteins and their annotated locations for NP_054642.2

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 2 lacks exons 5 which is present in the full-length variant 1.
    Source sequence(s)
    AK292590, AL132982, DB023187
    Consensus CDS
    CCDS5282.1
    UniProtKB/Swiss-Prot
    O60260
    Related
    ENSP00000355863.1, ENST00000366897.5
    Conserved Domains (4) summary
    cd01798
    Location:372
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    smart00647
    Location:285347
    IBR; In Between Ring fingers
    pfam01485
    Location:385425
    IBR; IBR domain, a half RING-finger domain
  3. NM_013988.2NP_054643.2  E3 ubiquitin-protein ligase parkin isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: Transcript variant 3 lacks exons 3 to 5 present in the full-length transcript variant 1.
    Source sequence(s)
    AK292590, AL132982, DB023187
    Consensus CDS
    CCDS5283.1
    UniProtKB/Swiss-Prot
    O60260
    Related
    ENSP00000355862.1, ENST00000366896.5
    Conserved Domains (4) summary
    cd01798
    Location:382
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:158
    UBQ; Ubiquitin homologues
    smart00647
    Location:164226
    IBR; In Between Ring fingers
    pfam01485
    Location:264304
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    161347417..162727802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535863.1XP_011534165.1  E3 ubiquitin-protein ligase parkin isoform X2

    Conserved Domains (4) summary
    cd01798
    Location:372
    parkin_N; amino-terminal ubiquitin-like of parkin protein
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    smart00647
    Location:312374
    IBR; In Between Ring fingers
    pfam01485
    Location:412452
    IBR; IBR domain, a half RING-finger domain
  2. XM_024446449.1XP_024302217.1  E3 ubiquitin-protein ligase parkin isoform X3

    Conserved Domains (2) summary
    pfam01485
    Location:234296
    IBR; IBR domain, a half RING-finger domain
    cd16627
    Location:157215
    RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
  3. XM_017010909.2XP_016866398.1  E3 ubiquitin-protein ligase parkin isoform X4

  4. XM_017010908.1XP_016866397.1  E3 ubiquitin-protein ligase parkin isoform X1

RNA

  1. XR_001743443.2 RNA Sequence

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