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Parkin mono-ubiquitinates Bcl-2 and regulates autophagy.
Chen D, Gao F, Li B, Wang H, Xu Y, Zhu C, Wang G. Chen D, et al. J Biol Chem. 2010 Dec 3;285(49):38214-23. doi: 10.1074/jbc.M110.101469. Epub 2010 Oct 2. J Biol Chem. 2010. PMID: 20889974 Free PMC article.
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.
Burchell VS, Nelson DE, Sanchez-Martinez A, Delgado-Camprubi M, Ivatt RM, Pogson JH, Randle SJ, Wray S, Lewis PA, Houlden H, Abramov AY, Hardy J, Wood NW, Whitworth AJ, Laman H, Plun-Favreau H. Burchell VS, et al. Nat Neurosci. 2013 Sep;16(9):1257-65. doi: 10.1038/nn.3489. Epub 2013 Aug 11. Nat Neurosci. 2013. PMID: 23933751 Free PMC article.