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NEO1 neogenin 1 [ Homo sapiens (human) ]

Gene ID: 4756, updated on 5-Aug-2022

Summary

Official Symbol
NEO1provided by HGNC
Official Full Name
neogenin 1provided by HGNC
Primary source
HGNC:HGNC:7754
See related
Ensembl:ENSG00000067141 MIM:601907; AllianceGenome:HGNC:7754
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NGN; IGDCC2; NTN1R2
Summary
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Expression
Broad expression in colon (RPKM 23.2), skin (RPKM 16.0) and 23 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See NEO1 in Genome Data Viewer
Location:
15q24.1
Exon count:
30
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (73051692..73305206)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (70869741..71122333)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (73344804..73597547)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984801 Neighboring gene nucleophosmin 1 pseudogene 42 Neighboring gene FKBP prolyl isomerase 1A pseudogene 2 Neighboring gene nucleophosmin 1 pseudogene 43 Neighboring gene microRNA 12135 Neighboring gene uncharacterized LOC105370890 Neighboring gene VISTA enhancer hs2161 Neighboring gene serine-aspartate repeat-containing protein I-like Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NEO1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547A066, DKFZp547B146

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables co-receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within iron ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in axonal growth cone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of plasma membrane protein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neogenin
Names
immunoglobulin superfamily DCC subclass member 2
neogenin homolog 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016965.1 RefSeqGene

    Range
    4980..257722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172623.1NP_001166094.1  neogenin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001166094.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB209412, AC068397, AL355708, BC143270, DB458571
    Consensus CDS
    CCDS53957.1
    UniProtKB/Swiss-Prot
    Q92859
    UniProtKB/TrEMBL
    Q59FP8
    Related
    ENSP00000453317.1, ENST00000560262.5
    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:739818
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:539628
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11581408
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  2. NM_001172624.1NP_001166095.1  neogenin isoform 3 precursor

    See identical proteins and their annotated locations for NP_001166095.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AB209412, AC068397, AL355708, BC143271, DB458571
    Consensus CDS
    CCDS58378.1
    UniProtKB/Swiss-Prot
    Q92859
    UniProtKB/TrEMBL
    Q59FP8
    Related
    ENSP00000453200.1, ENST00000558964.5
    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:739818
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:539628
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11471450
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  3. NM_002499.4NP_002490.2  neogenin isoform 1 precursor

    See identical proteins and their annotated locations for NP_002490.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB209412, AC129980, AL355708, BC117161, DB458571
    Consensus CDS
    CCDS10247.1
    UniProtKB/Swiss-Prot
    Q17RX1, Q92859
    UniProtKB/TrEMBL
    Q59FP8
    Related
    ENSP00000261908.6, ENST00000261908.11
    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:739818
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:539628
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11581461
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    73051692..73305206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432591.1XP_047288547.1  neogenin isoform X5

  2. XM_011521628.3XP_011519930.1  neogenin isoform X1

    See identical proteins and their annotated locations for XP_011519930.1

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11781481
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  3. XM_011521633.4XP_011519935.1  neogenin isoform X11

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11781428
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  4. XM_011521629.3XP_011519931.1  neogenin isoform X2

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11671470
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  5. XM_017022233.2XP_016877722.1  neogenin isoform X12

  6. XM_011521632.3XP_011519934.1  neogenin isoform X7

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11441447
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  7. XM_017022237.2XP_016877726.1  neogenin isoform X18

  8. XM_011521630.3XP_011519932.1  neogenin isoform X3

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11621465
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  9. XM_017022234.2XP_016877723.1  neogenin isoform X13

  10. XM_047432587.1XP_047288543.1  neogenin isoform X5

  11. XM_047432595.1XP_047288551.1  neogenin isoform X16

  12. XM_047432590.1XP_047288546.1  neogenin isoform X10

  13. XM_047432586.1XP_047288542.1  neogenin isoform X4

    UniProtKB/Swiss-Prot
    Q17RX1
    Related
    ENSP00000341198.5, ENST00000339362.9
  14. XM_047432593.1XP_047288549.1  neogenin isoform X15

  15. XM_047432588.1XP_047288544.1  neogenin isoform X6

  16. XM_047432596.1XP_047288552.1  neogenin isoform X17

  17. XM_047432589.1XP_047288545.1  neogenin isoform X8

  18. XM_017022231.2XP_016877720.1  neogenin isoform X9

  19. XM_047432598.1XP_047288554.1  neogenin isoform X19

  20. XM_047432592.1XP_047288548.1  neogenin isoform X14

  21. XM_047432600.1XP_047288556.1  neogenin isoform X20

  22. XM_005254408.2XP_005254465.1  neogenin isoform X1

    See identical proteins and their annotated locations for XP_005254465.1

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11781481
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  23. XM_017022232.2XP_016877721.1  neogenin isoform X5

    Conserved Domains (8) summary
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00409
    Location:158239
    IG; Immunoglobulin
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam06583
    Location:11511454
    Neogenin_C; Neogenin C-terminus
    pfam07679
    Location:250337
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:252255
    Ig; Ig strand A [structural motif]
    cd05722
    Location:52148
    IgI_1_Neogenin_like; First immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
    cd05723
    Location:344427
    IgI_4_Neogenin_like; Fourth immunoglobulin (Ig)-like domain in neogenin, and similar domains; member of the I-set of Ig superfamily (IgSF) domains
  24. XM_047432599.1XP_047288555.1  neogenin isoform X16

  25. XM_047432594.1XP_047288550.1  neogenin isoform X8

  26. XM_047432597.1XP_047288553.1  neogenin isoform X9

  27. XM_047432601.1XP_047288557.1  neogenin isoform X21

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    70869741..71122333
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)