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NEO1 neogenin 1 [ Homo sapiens (human) ]

Gene ID: 4756, updated on 7-Dec-2018

Summary

Official Symbol
NEO1provided by HGNC
Official Full Name
neogenin 1provided by HGNC
Primary source
HGNC:HGNC:7754
See related
Ensembl:ENSG00000067141 MIM:601907
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NGN; IGDCC2; NTN1R2
Summary
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Expression
Broad expression in colon (RPKM 23.2), skin (RPKM 16.0) and 23 other tissues See more
Orthologs

Genomic context

See NEO1 in Genome Data Viewer
Location:
15q24.1
Exon count:
30
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (73051715..73305206)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (73344056..73597547)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984801 Neighboring gene nucleophosmin 1 pseudogene 42 Neighboring gene FKBP prolyl isomerase 1A pseudogene 2 Neighboring gene nucleophosmin 1 pseudogene 43 Neighboring gene uncharacterized LOC105370890 Neighboring gene VISTA enhancer hs2161 Neighboring gene serine-aspartate repeat-containing protein I-like Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of NEO1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • CDO in myogenesis, organism-specific biosystem (from REACTOME)
    CDO in myogenesis, organism-specific biosystemCDO/Cdon (cell-adhesion-molecule-related/downregulated by oncogenes) is a type I transmembrane multifunctional co-receptor consisting of five immunoglobulin and three fibronectin type III (FNIII) rep...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Myogenesis, organism-specific biosystem (from REACTOME)
    Myogenesis, organism-specific biosystemMyogenesis, the formation of muscle tissue, is a complex process involving steps of cell proliferation mediated by growth factor signaling, cell differentiation, reorganization of cells to form myotu...
  • Netrin-1 signaling, organism-specific biosystem (from REACTOME)
    Netrin-1 signaling, organism-specific biosystemNetrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp547A066, DKFZp547B146

Gene Ontology Provided by GOA

Function Evidence Code Pubs
co-receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
axon guidance IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
iron ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
plasma membrane protein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neogenin
Names
immunoglobulin superfamily DCC subclass member 2
neogenin homolog 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016965.1 RefSeqGene

    Range
    5001..257723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001172623.1NP_001166094.1  neogenin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001166094.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB209412, AC068397, AL355708, BC143270, DB458571
    Consensus CDS
    CCDS53957.1
    UniProtKB/Swiss-Prot
    Q92859
    UniProtKB/TrEMBL
    Q59FP8
    Related
    ENSP00000453317.1, ENST00000560262.5
    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:739818
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:539628
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11581408
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  2. NM_001172624.1NP_001166095.1  neogenin isoform 3 precursor

    See identical proteins and their annotated locations for NP_001166095.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AB209412, AC068397, AL355708, BC143271, DB458571
    Consensus CDS
    CCDS58378.1
    UniProtKB/Swiss-Prot
    Q92859
    UniProtKB/TrEMBL
    Q59FP8
    Related
    ENSP00000453200.1, ENST00000558964.5
    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:739818
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:539628
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11471450
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  3. NM_002499.4NP_002490.2  neogenin isoform 1 precursor

    See identical proteins and their annotated locations for NP_002490.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB209412, AC129980, AL355708, BC117161, DB458571
    Consensus CDS
    CCDS10247.1
    UniProtKB/Swiss-Prot
    Q92859
    UniProtKB/TrEMBL
    Q59FP8
    Related
    ENSP00000261908.6, ENST00000261908.10
    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:739818
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:539628
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11581461
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    73051715..73305206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254408.1XP_005254465.1  neogenin isoform X3

    See identical proteins and their annotated locations for XP_005254465.1

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11781481
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  2. XM_017022232.1XP_016877721.1  neogenin isoform X7

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11511454
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  3. XM_017022234.1XP_016877723.1  neogenin isoform X9

  4. XM_011521628.2XP_011519930.1  neogenin isoform X3

    See identical proteins and their annotated locations for XP_011519930.1

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11781481
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  5. XM_017022233.1XP_016877722.1  neogenin isoform X8

  6. XM_011521632.2XP_011519934.1  neogenin isoform X4

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11441447
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  7. XM_017022237.1XP_016877726.1  neogenin isoform X12

  8. XM_011521630.2XP_011519932.1  neogenin isoform X2

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11621465
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  9. XM_017022231.1XP_016877720.1  neogenin isoform X5

  10. XM_011521633.3XP_011519935.1  neogenin isoform X6

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11781428
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  11. XM_011521629.2XP_011519931.1  neogenin isoform X1

    Conserved Domains (9) summary
    cd05722
    Location:54148
    Ig1_Neogenin; First immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00408
    Location:262326
    IGc2; Immunoglobulin C-2 Type
    cd05723
    Location:357427
    Ig4_Neogenin; Fourth immunoglobulin (Ig)-like domain in neogenin and similar proteins
    smart00060
    Location:759838
    FN3; Fibronectin type 3 domain
    smart00410
    Location:158239
    IG_like; Immunoglobulin like
    cd00063
    Location:559648
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:341427
    I-set; Immunoglobulin I-set domain
    pfam06583
    Location:11671470
    Neogenin_C; Neogenin C-terminus
    pfam13895
    Location:157239
    Ig_2; Immunoglobulin domain
  12. XM_017022236.2XP_016877725.1  neogenin isoform X11

  13. XM_017022235.2XP_016877724.1  neogenin isoform X10

  14. XM_017022238.2XP_016877727.1  neogenin isoform X13

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