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NEK2 NIMA related kinase 2 [ Homo sapiens (human) ]

Gene ID: 4751, updated on 2-Nov-2024

Summary

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Official Symbol
NEK2provided by HGNC
Official Full Name
NIMA related kinase 2provided by HGNC
Primary source
HGNC:HGNC:7745
See related
Ensembl:ENSG00000117650 MIM:604043; AllianceGenome:HGNC:7745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NLK1; RP67; NEK2A; HsPK21; PPP1R111
Summary
This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]
Expression
Biased expression in testis (RPKM 28.1), bone marrow (RPKM 3.8) and 6 other tissues See more
Orthologs
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Genomic context

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See NEK2 in Genome Data Viewer
Location:
1q32.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (211658256..211675621, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (210904362..210921749, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211831598..211848963, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372903 Neighboring gene Sharpr-MPRA regulatory region 10274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211794336-211794836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211805695-211806270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:211815933-211816768 Neighboring gene Sharpr-MPRA regulatory region 10021 Neighboring gene non-coding transcript regulating alternative splicing Neighboring gene farnesyl diphosphate synthase pseudogene 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2489 Neighboring gene Sharpr-MPRA regulatory region 55 Neighboring gene NEK2 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:211868601-211869100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1791 Neighboring gene NANOG hESC enhancer GRCh37_chr1:211877490-211877991 Neighboring gene uncharacterized LOC105372904

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Integrative Bioinformatics Analysis Identifies NEK2 as a Potential Biomarker in Head and Neck Squamous Cell Carcinoma. Liu S, et al. J Comput Biol, 2020 Jan. PMID 31460782
  2. Nek2 as a novel molecular target for the treatment of breast carcinoma. Tsunoda N, et al. Cancer Sci, 2009 Jan. PMID 19038001, Free PMC Article
  3. NEK2 induces osteoclast differentiation and bone destruction via heparanase in multiple myeloma. Hao M, et al. Leukemia, 2017 Jul. PMID 28400617, Free PMC Article
  4. Effect of NIMA-related kinase 2B on the sensitivity of breast cancer to paclitaxel in vitro and vivo. Wang Y, et al. Tumour Biol, 2017 May. PMID 28475000
  5. Clinical significance and prognostic value of Nek2 protein expression in colon cancer. Lu L, et al. Int J Clin Exp Pathol, 2015. PMID 26823916, Free PMC Article

See all (202) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Function of NEK2 in clear cell renal cell carcinoma and its effect on the tumor microenvironment.
    Title: Function of NEK2 in clear cell renal cell carcinoma and its effect on the tumor microenvironment.
  2. NEK2 promotes TP53 ubiquitination to enhance the proliferation and migration of TP53 wild-type glioblastoma cells.
    Title: NEK2 promotes TP53 ubiquitination to enhance the proliferation and migration of TP53 wild-type glioblastoma cells.
  3. Abnormal methylation mediated upregulation of LINC00857 boosts malignant progression of lung adenocarcinoma by modulating the miR-486-5p/NEK2 axis.
    Title: Abnormal methylation mediated upregulation of LINC00857 boosts malignant progression of lung adenocarcinoma by modulating the miR-486-5p/NEK2 axis.
  4. NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1.
    Title: NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1.
  5. [Expression and clinical significance of NEK2 and EMT related molecules in oral squamous cell carcinoma].
    Title: [Expression and clinical significance of NEK2 and EMT related molecules in oral squamous cell carcinoma].
  6. Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.
    Title: Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.
  7. Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers.
    Title: Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers.
  8. Molecular characteristics, oncogenic roles, and relevant immune and pharmacogenomic features of NEK2 in gastric cancer.
    Title: Molecular characteristics, oncogenic roles, and relevant immune and pharmacogenomic features of NEK2 in gastric cancer.
  9. NEK2 is associated with poor prognosis of clear cell renal cell carcinoma and promotes tumor cell growth and metastasis.
    Title: NEK2 is associated with poor prognosis of clear cell renal cell carcinoma and promotes tumor cell growth and metastasis.
  10. NEK2 inactivates the Hippo pathway to advance the proliferation of cervical cancer cells by cooperating with STRIPAK complexes.
    Title: NEK2 inactivates the Hippo pathway to advance the proliferation of cervical cancer cells by cooperating with STRIPAK complexes.
Submit: New GeneRIF Correction See all GeneRIFs (128)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Retinitis pigmentosa 67
MedGen: C3809954 OMIM: 615565 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with NEK2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in blastocyst development IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome separation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome segregation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in mitotic spindle assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of centriole-centriole cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic centrosome separation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
 PubMed 
involved_in spindle assembly TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in condensed nuclear chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
colocalizes_with kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase Nek2
Names
NIMA (never in mitosis gene a)-related kinase 2
nimA-like protein kinase 1
nimA-related protein kinase 2
protein phosphatase 1, regulatory subunit 111
NP_001191111.1
NP_001191112.1
NP_002488.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029112.1 RefSeqGene

    Range
    5010..17859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204182.2 → NP_001191111.1  serine/threonine-protein kinase Nek2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK225522, BT019729, DC407297
    Consensus CDS
    CCDS73024.1
    UniProtKB/TrEMBL
    B4DZU0, F6U4U2
    Related
    ENSP00000440237.2, ENST00000540251.5
    Conserved Domains (2) summary
    smart00220
    Location:8 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08217
    Location:7 → 271
    STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

  2. NM_001204183.2 → NP_001191112.1  serine/threonine-protein kinase Nek2 isoform 2

    See identical proteins and their annotated locations for NP_001191112.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a frame-shift and a shorter isoform (2, also known as NEK2B) with a distinct C-terminus compared to isoform 1. Isoforms 1 and 2 have been reported to exhibit distinct pattern of expression during mitosis (PMID:11742531).
    Source sequence(s)
    AC096637, AY045701, BT019729, BU517064, DC407297
    Consensus CDS
    CCDS55682.1
    UniProtKB/TrEMBL
    B4DZU0
    Related
    ENSP00000355965.3, ENST00000366998.4
    Conserved Domains (2) summary
    smart00220
    Location:8 → 271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08217
    Location:7 → 271
    STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

  3. NM_002497.4 → NP_002488.1  serine/threonine-protein kinase Nek2 isoform 1

    See identical proteins and their annotated locations for NP_002488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longest isoform (1, also known as NEK2A). The C-terminus (aa 399-445) of this isoform was shown to be responsible for its nucleolar localization (PMID:15161910). Isoforms 1 and 2 (which differ at the C-terminus) have also been reported to exhibit distinct pattern of expression during mitosis (PMID:11742531).
    Source sequence(s)
    AK223353, BC043502, BT019729, DC407297
    Consensus CDS
    CCDS1500.1
    UniProtKB/Swiss-Prot
    P51955, Q53FD6, Q5I1Z9, Q5VXZ1, Q6NZX8, Q7Z634, Q86XH2, Q96QN9
    UniProtKB/TrEMBL
    B4DZU0
    Related
    ENSP00000355966.4, ENST00000366999.9
    Conserved Domains (1) summary
    cd08217
    Location:7 → 271
    STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    211658256..211675621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    210904362..210921749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51955.1 GenPept UniProtKB/Swiss-Prot:P51955

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials
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