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NEK2 NIMA related kinase 2 [ Homo sapiens (human) ]

Gene ID: 4751, updated on 7-Oct-2018

Summary

Official Symbol
NEK2provided by HGNC
Official Full Name
NIMA related kinase 2provided by HGNC
Primary source
HGNC:HGNC:7745
See related
Ensembl:ENSG00000117650 MIM:604043; Vega:OTTHUMG00000037121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NLK1; RP67; NEK2A; HsPK21; PPP1R111
Summary
This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011]
Expression
Biased expression in testis (RPKM 28.1), bone marrow (RPKM 3.8) and 6 other tissues See more
Orthologs

Genomic context

See NEK2 in Genome Data Viewer
Location:
1q32.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (211658256..211675630, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (211831598..211848972, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372903 Neighboring gene long intergenic non-protein coding RNA 1693 Neighboring gene farnesyl diphosphate synthase pseudogene 8 Neighboring gene uncharacterized LOC91548 Neighboring gene uncharacterized LOC105372904

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The amplified luminescent proximity homogeneous assay (AlphaScreen) identifies the interaction of HIV-1 Gag with NEK2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
blastocyst development IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
centrosome separation IDA
Inferred from Direct Assay
more info
PubMed 
chromosome segregation IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
mitotic sister chromatid segregation IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle assembly IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA binding IEA
Inferred from Electronic Annotation
more info
 
negative regulation of centriole-centriole cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic centrosome separation TAS
Traceable Author Statement
more info
PubMed 
regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
PubMed 
spindle assembly TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
condensed nuclear chromosome IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
midbody IEA
Inferred from Electronic Annotation
more info
 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
protein-containing complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase Nek2
Names
NIMA (never in mitosis gene a)-related kinase 2
nimA-like protein kinase 1
nimA-related protein kinase 2
protein phosphatase 1, regulatory subunit 111
NP_001191111.1
NP_001191112.1
NP_002488.1
XP_005273204.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029112.1 RefSeqGene

    Range
    5001..22375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204182.1NP_001191111.1  serine/threonine-protein kinase Nek2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK225522, BT019729, DC407297
    Consensus CDS
    CCDS73024.1
    UniProtKB/Swiss-Prot
    P51955
    UniProtKB/TrEMBL
    F6U4U2
    Related
    ENSP00000440237.2, ENST00000540251.5
    Conserved Domains (2) summary
    smart00220
    Location:8271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08217
    Location:7271
    STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2
  2. NM_001204183.1NP_001191112.1  serine/threonine-protein kinase Nek2 isoform 2

    See identical proteins and their annotated locations for NP_001191112.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs at the 3' end compared to variant 1. This results in a frame-shift and a shorter isoform (2, also known as NEK2B) with a distinct C-terminus compared to isoform 1. Isoforms 1 and 2 have been reported to exhibit distinct pattern of expression during mitosis (PMID:11742531).
    Source sequence(s)
    AY045701, BT019729, BU517064, DC407297
    Consensus CDS
    CCDS55682.1
    UniProtKB/Swiss-Prot
    P51955
    Related
    ENSP00000355965.3, OTTHUMP00000035217, ENST00000366998.4, OTTHUMT00000090155
    Conserved Domains (2) summary
    smart00220
    Location:8271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08217
    Location:7271
    STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2
  3. NM_002497.3NP_002488.1  serine/threonine-protein kinase Nek2 isoform 1

    See identical proteins and their annotated locations for NP_002488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longest isoform (1, also known as NEK2A). The C-terminus (aa 399-445) of this isoform was shown to be responsible for its nucleolar localization (PMID:15161910). Isoforms 1 and 2 (which differ at the C-terminus) have also been reported to exhibit distinct pattern of expression during mitosis (PMID:11742531).
    Source sequence(s)
    AK223353, BC043502, BT019729, DC407297
    Consensus CDS
    CCDS1500.1
    UniProtKB/Swiss-Prot
    P51955
    Related
    ENSP00000355966.4, OTTHUMP00000035216, ENST00000366999.8, OTTHUMT00000090154
    Conserved Domains (2) summary
    smart00220
    Location:8271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08217
    Location:7271
    STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    211658256..211675630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273147.2XP_005273204.1  serine/threonine-protein kinase Nek2 isoform X1

    UniProtKB/Swiss-Prot
    P51955
    Conserved Domains (2) summary
    smart00220
    Location:8271
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08217
    Location:7271
    STKc_Nek2; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2
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